Abstract: Methods of diagnosing and treating vitiligo.

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to a tumor. The oligonucleotide is conjugated to a dendron comprising an end group, a phosphate group, and/or a hydrophobic chain.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the skin. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: This disclosure provides compositions, systems, and methods for the topical delivery of therapeutic oligonucleotides with microneedle particles.

Abstract: This disclosure relates to novel IFN-? signaling pathway target gene targeting sequences. Novel IFNGR1, JAK1, JAK2, and STAT1 targeting oligonucleotides for the treatment of vitiligo are also provided.

Abstract: In its various aspects and embodiments, the invention comprises a method for treating vitiligo in a patient comprising administering a composition comprising an effective amount of at least one Janus kinase inhibitor and phototherapy.

Abstract: Provided herein are antibody molecules that bind specifically to CD122 and antigen-binding portions thereof and related compositions, nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.

Abstract: Provided herein are antibody molecules that bind specifically to CD122 and antigen-binding portions thereof and related compositions, nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: Described herein are AIM2 inhibitors (e.g., inhibitory nucleic acids), vectors, cells (e.g., dendritic cells), and compositions comprising same, and methods of using same in the treatment of cancer (e.g., melanoma).

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: In its various aspects and embodiments, the invention comprises a method for treating vitiligo in a patient comprising administering a composition comprising an effective amount of at least one Janus kinase inhibitor and phototherapy.

Abstract: Embodiments of the present disclosure provide systems, apparatus and methods for device management and tracking. Embodiments further disclose systems, apparatus and methods for conserving battery power to extend the operational life of the device. Tracking features may include redundant elements or operations for determining a device's movement or location. Such redundant elements or operations may be prioritized based upon power consumption rates associated with the element or operation. System features may include management controls for tracking, alerts and operations. The management controls may be operational through monitoring devices, web portals or other remote devices.

Abstract: Embodiments of the present disclosure provide systems, apparatus and methods for device management and tracking. Embodiments further disclose systems, apparatus and methods for conserving battery power to extend the operational life of the device. Tracking features may include redundant elements or operations for determining a device's movement or location. Such redundant elements or operations may be prioritized based upon power consumption rates associated with the element or operation. System features may include management controls for tracking, alerts and operations. The management controls may be operational through monitoring devices, web portals or other remote devices.

Abstract: A wheel attachment assembly facilitates attachment of a trailer to a towing vehicle by providing a wheeled surface for transporting the trailer to the towing vehicle. The assembly includes a mount having a back wall and a bottom wall. The back wall is coupled to and extends upwardly from a rear edge of the bottom wall. The bottom wall is configured to support a jack post coupled to a tongue of a trailer wherein the jack post selectively raises and lowers the tongue of the trailer. A swivelable caster is coupled to a bottom surface of the bottom wall.