Abstract: A method of creating an anastomosis is provided using a stapling assembly including a body extending distally along a longitudinal axis and a deck member defining a deck surface. The deck surface includes a first array of staple openings comprising a herringbone pattern, and each staple opening of the first array of staple openings has a same size. The method includes positioning an anvil within a first lumen of a patient and positioning the stapling assembly within a second lumen of the patient. The method also includes releasably coupling the anvil with the stapling assembly and compressing tissue of the first and second lumens between the anvil and the deck member. The method further includes actuating a plurality of staple drivers to drive a first plurality of staples distally and parallel to the longitudinal axis from the first array of staple openings into the tissue to define the anastomosis.

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: A method of suturing a trocar path incision in a tissue of a patient with an obturator includes inserting the obturator through the tissue such that a shaft of the obturator extends through a tissue opening about the trocar path incision and a distal tip of the obturator is positioned within a cavity of the patient. The method also includes directing the suture via a suturing feature with the obturator inserted through the tissue in order to direct the suture relative to the tissue. Furthermore, the method includes closing the tissue opening about the trocar path incision with the suture.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to a tumor. The oligonucleotide is conjugated to a dendron comprising an end group, a phosphate group, and/or a hydrophobic chain.

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the skin. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: This disclosure provides compositions, systems, and methods for the topical delivery of therapeutic oligonucleotides with microneedle particles.

Abstract: This disclosure relates to novel IFN-? signaling pathway target gene targeting sequences. Novel IFNGR1, JAK1, JAK2, and STAT1 targeting oligonucleotides for the treatment of vitiligo are also provided.

Abstract: In its various aspects and embodiments, the invention comprises a method for treating vitiligo in a patient comprising administering a composition comprising an effective amount of at least one Janus kinase inhibitor and phototherapy.

Abstract: Provided herein are antibody molecules that bind specifically to CD122 and antigen-binding portions thereof and related compositions, nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.

Abstract: Provided herein are antibody molecules that bind specifically to CD122 and antigen-binding portions thereof and related compositions, nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: Described herein are AIM2 inhibitors (e.g., inhibitory nucleic acids), vectors, cells (e.g., dendritic cells), and compositions comprising same, and methods of using same in the treatment of cancer (e.g., melanoma).

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: Methods of diagnosing and treating vitiligo.

Abstract: In its various aspects and embodiments, the invention comprises a method for treating vitiligo in a patient comprising administering a composition comprising an effective amount of at least one Janus kinase inhibitor and phototherapy.

Abstract: Embodiments of the present disclosure provide systems, apparatus and methods for device management and tracking. Embodiments further disclose systems, apparatus and methods for conserving battery power to extend the operational life of the device. Tracking features may include redundant elements or operations for determining a device's movement or location. Such redundant elements or operations may be prioritized based upon power consumption rates associated with the element or operation. System features may include management controls for tracking, alerts and operations. The management controls may be operational through monitoring devices, web portals or other remote devices.

Abstract: Embodiments of the present disclosure provide systems, apparatus and methods for device management and tracking. Embodiments further disclose systems, apparatus and methods for conserving battery power to extend the operational life of the device. Tracking features may include redundant elements or operations for determining a device's movement or location. Such redundant elements or operations may be prioritized based upon power consumption rates associated with the element or operation. System features may include management controls for tracking, alerts and operations. The management controls may be operational through monitoring devices, web portals or other remote devices.