Patents by Inventor John E. Maggio

John E. Maggio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photolabeling reagent
    Patent number: 5986136
    Abstract: Disclosed is a compound represent by the following structural formula: ##STR1## X is --H or an amine protecting group; --OY is --OH, an activating group for a carboxylic acid or a protecting group for a carboxylic acid; Z is --H or a phenolic protecting group, with the proviso that Z is not a straight chained, unsaturated alkyl group such as, for example, methyl or ethyl, and at least one of X, Y or Z is not --H.Also disclosed is a photoreactive polypeptide having a polypeptide chain comprising a residue of the compound described above. Also disclosed is a method of labeling a target molecule which forms a complex with the photoreactive polypolypeptide by photolyzing the photoreactive polypeptide when complexed with the target molecule.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: November 16, 1999
    Assignee: President and Fellows of Harvard College
    Inventor: John E. Maggio
  • In Vitro method for screening .beta.-amyloid deposition
    Patent number: 5721106
    Abstract: The present invention provides: a labelled .beta.-amyloid peptide or active fragment; a composition including the labelled .beta.-amyloid peptide or active fragment thereof and a pharmaceutical carrier; a method for identifying active fragments of .beta.-amyloid peptide; a method for labelling the .beta.-amyloid peptide or an active fragment thereof; methods of using the labelled peptide or peptide fragment for detecting or monitoring Alzheimer's disease in a patient; and methods for screening agents that enhance or inhibit .beta.-amyloid aggregation or deposition onto tissue or other amyloid substance, such as silk.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: February 24, 1998
    Assignees: Regents of the University of Minnesota, President and Fellows of Harvard College
    Inventors: John E. Maggio, Patrick W. Mantyh
  • Labelled .beta.-amyloid peptide and methods of screening for Alzheimer's disease
    Patent number: 5434050
    Abstract: The present invention provides: a labelled .beta.-amyloid peptide of active fragment; a composition including the labelled .beta.-amyloid peptide or active fragment thereof and a pharmaceutical carrier; a method for labelling the .beta.-amyloid peptide or an active fragment thereof, and methods of using the labelled peptide or peptide fragment for detecting or monitoring Alzheimer's disease in a patient.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: July 18, 1995
    Assignees: Regents of the University of Minnesota, President & Fellows of Harvard College
    Inventors: John E. Maggio, Patrick W. Mantyh