Abstract: An apparatus and method that allows the visualization of leakage of cell culture media through a conduit wall of a tissue-engineered biological construct such as a semilunar heart valve or valve graft under controlled physiologic conditions. The apparatus and method also allows for the assessment of valve function and intraluminal flow using conventional imaging modalities such as ultrasonic and magnetic resonance imaging. The apparatus allows the qualitative and quantitative evaluation of structural and functional characteristics of a condition tissue engineered construct prior to implantation using a valve housing and chamber and a flow-pressure simulator.

Abstract: The present invention is directed to novel, less invasive and improved methods of tissue-engineering of constructs that require an endothelial surface such as blood vessels and heart valves. The constructs of the present invention possess long-term patency. The method of the present invention is particularly suited for making small diameter vessels to replace clogged or damaged coronary blood vessels, for making trileaflet heart valve conduits to replace damaged or malformed pulmonic and aortic valves, and for other vascular structures that require an endothelial surface.

Abstract: An apparatus and method that allows the visualization of leakage of cell culture media through a conduit wall of a tissue-engineered biological construct such as a semilunar heart valve or valve graft under controlled physiologic conditions. The apparatus and method also allows for the assessment of valve function and intraluminal flow using conventional imaging modalities such as ultrasonic and magnetic resonance imaging. The apparatus allows the qualitative and quantitative evaluation of structural and functional characteristics of a condition tissue engineered construct prior to implantation using a valve housing and chamber and a flow-pressure simulator.

Abstract: A computer implemented system for inter-domain analysis is disclosed. The system includes a domain engine (234), associated with a first supply chain entity, having a local model representing a supply chain activity of the first supply chain entity. The domain engine (234) operable to generate a model agent (240) that represents a partial replica of the local model. The system also includes another domain engine (236), associated with a second supply chain entity, having a local model representing a supply chain activity of the second supply chain entity. The other domain engine is operable to generate a model agent representing a partial replica of the local model. The domain engines (234 and 236) further operate to expand the respective local models using the remote model agents (240) to accomplish local inter-domain analysis. In one embodiment, the model agents (240) can be data model agents, object model agents and behavior model agents.

Abstract: A computer implemented system enables a global user interface. The system includes a plurality of application engines (110, 114) and a user interface process (124). The system also includes a visual information broker (118) that has dynamically loadable adapters (120, 122) where each adapter (120, 122) is appropriate for accessing one of a plurality of types of engines. The visual information broker (118) can thereby interface between an engine interface (112, 116) of an application engine (110, 114) and the user interface process (124) by dynamically loading an adapter (120, 122) appropriate for that type of engine. The computer system also can enable a global messaging bus. The system includes native messaging supported by a network messaging layer (180). A plurality of message bus manager processes (176) each include a dynamically loadable message bus adapter (178) and a message bus application program interface (174).

Abstract: A computer implemented system for inter-domain analysis is disclosed. The system includes a domain engine (234), associated with a first supply chain entity, having a local model representing a supply chain activity of the first supply chain entity. The domain engine (234) operable to generate a model agent (240) that represents a partial replica of the local model. The system also includes another domain engine (236), associated with a second supply chain entity, having a local model representing a supply chain activity of the second supply chain entity. The other domain engine is operable to generate a model agent representing a partial replica of the local model. The domain engines (234 and 236) further operate to expand the respective local models using the remote model agents (240) to accomplish local inter-domain analysis. In one embodiment, the model agents (240) can be data model agents, object model agents and behavior model agents.

Abstract: A computer implemented system and process enables inter-domain interaction. The system includes a native plane (292) that has a first native source (294) associated with a first domain and a second native source (296) associated with a second domain. The first and second native sources (294, 296) include domain related data and applications. The system also includes an inter-domain connectivity plane (298) that has a first domain engine (300) associated with the first domain, and a second domain engine (302) associated with the second domain. The first and second domain engines (300, 302) operate to perform domain analysis functions. The system further includes adapters associated with the first and second native sources (294, 296) where the adapters operate to abstract data and information from the first and second native sources (294, 296) onto the inter-domain connectivity plane (298).