Abstract: The present invention relates to devices and methods for enhancing the rate and efficacy of permeation of a drug into and through skin and into the circulatory system utilizing ultrasound.

Abstract: A method and apparatus are provided for controlling the dispensing of a primary liquid from a pressurized source of primary liquid. Primary liquid is admitted through an inlet valve to a primary chamber having a primary element which is biased toward an initial position but is movable away from the initial position when subjected to the source pressure of the primary liquid. A sensor determines when the primary element has moved away from an initial position to a predetermined final position, and the inlet valve is closed in response thereto. The difference between the initial and final positions defines a predetermined dispensing volume. An outlet valve is opened to dispense the dispensing volume under the biasing force of the primary element which returns to the initial position. A sensor determines when the primary element has returned to the initial position, and the outlet valve is closed in response thereto.

Abstract: A solution pumping system is disclosed which is embodied as a disposable pump cassette including a self-contained positive displacement pump, and an associated pump driver including a reciprocable pump piston for driving the pump of the cassette. This system is particularly suited for use in compounding in preparation of parenteral solutions for administration to patients. In order to promote high liquid output with minimum peak pumping pressures, the controls of the system operate to provide a "square" pumping pressure waveform, thus optimizing performance of the system. This is achieved by selectively varying the velocity of the pump piston during its operation.

Abstract: A solution pumping system including a disposable pump cassette is disclosed, with the system configured for efficient and accurate preparation of parenteral admixture solutions. The system includes a pump driver having a reciprocable pump plunger and a plurality of associated valve actuators. The disposable pump cassette of the system is configured for removable positioning in operative association with the pump driver, and includes a positive displacement pump configured for operation by the reciprocable pump plunger. The pump cassette further includes a plurality of liquid inlets, and at least one liquid outlet joined in fluid communication with the inlets. By selective operation of the valve actuators of the pump driver, one or more selected source solutions are drawn through the pump inlets by the positive displacement pump, and directed through the pump outlet to an admixture solution container.

Abstract: In an apparatus for testing pneumatic flow resistance of a test component, such as an air filter useful in a system for admixing parenteral solutions, a pneumatic bridge has two branches connected, via a filter, a flow restrictor, and a flowmeter, to a source of gas under regulated pressure. Each branch comprises two arms with a centerpoint. The bridge has a pressure transducer connected between the centerpoints and arranged to detect pressure imbalances in the bridge. Each arm comprises a flow restrictor, namely a needle valve, which is calibrated via a vernier head. The valves are adjustable to balance the bridge. In one arm, in which the needle valve can be fully opened, the test component is connectible to constitute a flow restrictor. The transducer produces an output displayed via a digital voltmeter, which may be calibrated.

Abstract: A method of detecting occlusions in a solution pumping system includes monitoring and analyzing pressures within the system during selected portions of a pumping cycle. The pumping system of the illustrated embodiment includes a positive displacement pump operated by a reciprocable pump piston, with analysis of pressures within the system identifying those conditions which reflect the presence of an occlusion either upstream or downstream of the positive displacement pump. A suitable signal or alarm can then be activated to alert operating personnel.

Abstract: A combination comprising a syringe, an adaptor, a check valve, and associated connectors for an intravenous infuser for patient-controlled analgesia. The infuser comprises a cradle adapted to receive an annular or disc-shaped element fitting into the cradle and a switch adapted to disable the infuser unless such an element is fitted into the cradle. The syringe comprises a vial, a plunger arranged within the vial for relative movement of the plunger and the vial, a tubular needle extending through an axial hole of the plunger, and a flange mounted around the needle and spaced from the plunger but too small to fit into the cradle. An adaptor having an outer rim adapted to fit over the flange and into the cradle and a check valve mounted operatively in the adaptor are connected by tubular connectors to the flange. The check valve allows an infusible liquid to flow from a chamber within the vial, through the tubular needle, and through the check valve, but not oppositely.

Abstract: An apparatus and method for welding or thermally bonding parts of thermoplastic material by subjecting a die to high frequency electromagnetic radiation to effect heating thereof and heating of thermoplastic parts in contact with the heated die. The die is continuously cooled to permit rapid cooling thereof and of the parts in contact therewith upon deenergization of the source to reduce cycle time and facilitate automated production techniques using a single source and multiple die stations successively exposed to the source for heating and being rapidly cooled thereafter due to the continuous cooling thereof.

Abstract: A device for automatically transferring a piercing pin from the port of one medical liquid container to the port of another medical liquid container. The ports are mounted to the device in opposing relationship. The piercing pin is inverted at an intermediate position between the ports.

Abstract: A plug is provided within a port in a flexible container. Extending from the port is a piece of flexible tubing which is used to connect with other tubing in a fluid system. Fluid is dispensed from the flexible container by grasping the end of the plug extending into the flexible container. The plug is then pulled into the interior of the container so that the opposite end of the plug which seals the flexible tubing extending from the port is unseated. The flexible tubing extending from the port is now open to the flow of fluid from the flexible container.