Patents by Inventor John E. Park
John E. Park has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9211330Abstract: The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.Type: GrantFiled: August 29, 2013Date of Patent: December 15, 2015Assignee: Ablynx N.V.Inventors: John E. Park, Cornelia Dorner-Ciossek, Stefan Hoerer, Lothar Kussmaul, Martin Lenter, Katharina Zimmerman, Gerald Beste, Toon Laeremans, Pascal Gerard Merchiers, Jo Vercammen
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Publication number: 20140030275Abstract: The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.Type: ApplicationFiled: August 29, 2013Publication date: January 30, 2014Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: John E. PARK, Cornelia DORNER-CIOSSEK, Stefan HOERER, Lothar KUSSMAUL, Martin LENTER, Katharina ZIMMERMANN, Gerald BESTE, Toon LAEREMANS, Pascal MERCHIERS, Jo VERCAMMEN
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Patent number: 8614308Abstract: The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.Type: GrantFiled: September 14, 2012Date of Patent: December 24, 2013Assignee: Boehringer Ingelheim International GmbHInventors: John E. Park, Cornelia Dorner-Ciossek, Stefan Hoerer, Lothar Kussmaul, Martin Lenter, Katharina Zimmermann, Gerald Beste, Toon Laeremans, Pascal Merchiers, Jo Vercammen
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Publication number: 20130017209Abstract: The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.Type: ApplicationFiled: September 14, 2012Publication date: January 17, 2013Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: John E. PARK, Cornelia DORNER-CIOSSEK, Stefan HOERER, Lothar KUSSMAUL, Martin LENTER, Katharina ZIMMERMANN, Gerald BESTE, Toon LAEREMANS, Pascal MERCHIERS, Jo VERCAMMEN
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Patent number: 8337845Abstract: The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.Type: GrantFiled: March 2, 2011Date of Patent: December 25, 2012Assignee: Boehringer Ingelheim International GmbHInventors: John E. Park, Cornelia Dorner-Ciossek, Stefan Hoerer, Lothar Kussmaul, Martin Lenter, Katharina Zimmermann, Gerald Beste, Toon Laeremans, Pascal Merchiers, Jo Vercammen
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Publication number: 20120058118Abstract: The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.Type: ApplicationFiled: March 2, 2011Publication date: March 8, 2012Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: John E. PARK, Cornelia DORNER-CIOSSEK, Stefan HOERER, Lothar KUSSMAUL, Martin LENTER, Katharina ZIMMERMANN, Gerald BESTE, Toon LAEREMANS, Pascal MERCHIERS, Jo VERCAMMEN
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Patent number: 6872569Abstract: The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The present invention also relates to spermatids produced by the method described above, where the spermatids are haploid. The present invention also involves a method of overcoming male infertility in mammals involving the use of the haploid round spermatids produced by the in vitro spermatogenesis method of the present invention. The present invention also relates to isolated haploid spermatids.Type: GrantFiled: May 16, 2002Date of Patent: March 29, 2005Assignee: Cornell Research Foundation, Inc.Inventors: Dong Ryul Lee, Michael T. Kaproth, John E. Parks
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Patent number: 6846910Abstract: The invention involves dimeric forms of the protein known as fibroblast activation protein alpha, or “FAP?” and its uses.Type: GrantFiled: March 10, 1999Date of Patent: January 25, 2005Assignees: Ludwig Institute for Cancer Research, Boehringer Ingelheim International GmbHInventors: Rainer Zimmermann, John E. Park, Wolfgang Rettig, Lloyd J. Old
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Patent number: 6613879Abstract: The invention relates to a prodrug that is capable of being converted into a drug by the catalytic action of human fibroblast activation protein (FAP&agr;), said prodrug having a cleavage site which is recognised by FAP&agr;, and said drug being cytotoxic or cytostatic under physiological conditions.Type: GrantFiled: April 21, 2000Date of Patent: September 2, 2003Assignees: Boehringer Ingelheim Pharma KG, Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Raymond A. Firestone, Wolfgang J. Rettig, Martin Lenter, Stefan Peters, Pilar Garin-Chesa, Juergen Mack, Dietmar Leipert, John E. Park, Leila A. Telan
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Publication number: 20030027329Abstract: The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The present invention also relates to spermatids produced by the method described above, where the spermatids are haploid. The present invention also involves a method of overcoming male infertility in mammals involving the use of the haploid round spermatids produced by the in vitro spermatogenesis method of the present invention. The present invention also relates to isolated haploid spermatids.Type: ApplicationFiled: May 16, 2002Publication date: February 6, 2003Inventors: Dong Ryul Lee, Michael T. Kaproth, John E. Parks
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Publication number: 20020034789Abstract: The invention involves dimeric forms of the protein known as fibroblast activation protein alpha, or “FAP&agr;” and its uses.Type: ApplicationFiled: March 10, 1999Publication date: March 21, 2002Inventors: RAINER ZIMMERMANN, JOHN E. PARK, WOLFGANG RETTIG, LLOYD J. OLD
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Patent number: 5965373Abstract: The invention involves dimeric forms of the protein known as fibroblast activation protein alpha, or "FAP.alpha." and its uses.Type: GrantFiled: October 1, 1997Date of Patent: October 12, 1999Assignee: Ludwig Institute for Cancer ResearchInventors: Rainer Zimmermann, John E. Park, Wolfgang Rettig, Lloyd J. Old
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Patent number: 5767242Abstract: The invention involves dimeric forms of the protein known as fibroblast activation protein alpha, or "FAP.alpha." and its uses.Type: GrantFiled: March 18, 1996Date of Patent: June 16, 1998Assignees: Boehringer Ingelheim Int'l GmbH, Ludwig Institute For Cancer ResearchInventors: Rainer Zimmermann, John E. Park, Wolfgang Rettig, Lloyd J. Old
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Patent number: 4828440Abstract: A nut is comprised of a one piece stamping having a base wall with an integrally formed conical nut. A frame member has a bolt receiving first aperture in a first planar wall and a nut receiving second aperture in a second planar wall extending at a generally perpendicular angle with respect to the first planar wall. The stamping has integral stop tabs which engage with the frame member to limit the insertion of the stamping into the second aperture so that the conical nut is registered with the bolt receiving first aperture. First and second integral flexure arms flex inwardly upon insertion of the stamping through the second aperture and then engage with the inner surface of the frame member to retain the stamping against removal from the frame member.Type: GrantFiled: July 22, 1988Date of Patent: May 9, 1989Assignee: General Motors CorporationInventors: Robert L. Anderson, John E. Parks