Abstract: The present disclosure relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods using such ADCs, and methods for making such ADCs.

Abstract: In one aspect, a lighted tip for attachment to a flexible rod comprises a tip body having proximal and distal ends, a mechanical connector at the proximal end, a lens connected to the distal end, a light source that emits light through the lens, and a holder coupled to the light source and the lens. A circuit is completed or interrupted as the holder moves in relation to the tip body, thereby switching the light source on or off. In another aspect, a lighted tip for attachment to a flexible rod comprises a lens forming a distal end of the lighted tip. The lens is cylindrical over at least some of its length, and the tip further includes a light source at least partially within the cylindrical lens portion and a mechanical connector at a proximal end if the lighted tip, for connecting the tip to the flexible rod.

Abstract: In one aspect, a lighted tip for attachment to a flexible rod comprises a tip body having proximal and distal ends, a mechanical connector at the proximal end, a lens connected to the distal end, a light source that emits light through the lens, and a holder coupled to the light source and the lens. A circuit is completed or interrupted as the holder moves in relation to the tip body, thereby switching the light source on or off. In another aspect, a lighted tip for attachment to a flexible rod comprises a lens forming a distal end of the lighted tip. The lens is cylindrical over at least some of its length, and the tip further includes a light source at least partially within the cylindrical lens portion and a mechanical connector at a proximal end if the lighted tip, for connecting the tip to the flexible rod.

Abstract: In one aspect, a lighted tip for attachment to a flexible rod comprises a tip body having proximal and distal ends, a mechanical connector at the proximal end, a lens connected to the distal end, a light source that emits light through the lens, and a holder coupled to the light source and the lens. A circuit is completed or interrupted as the holder moves in relation to the tip body, thereby switching the light source on or off. In another aspect, a lighted tip for attachment to a flexible rod comprises a lens forming a distal end of the lighted tip. The lens is cylindrical over at least some of its length, and the tip further includes a light source at least partially within the cylindrical lens portion and a mechanical connector at a proximal end if the lighted tip, for connecting the tip to the flexible rod.

Abstract: In one aspect, a lighted tip for attachment to a flexible rod comprises a tip body having proximal and distal ends, a mechanical connector at the proximal end, a lens connected to the distal end, a light source that emits light through the lens, and a holder coupled to the light source and the lens. A circuit is completed or interrupted as the holder moves in relation to the tip body, thereby switching the light source on or off. In another aspect, a lighted tip for attachment to a flexible rod comprises a lens forming a distal end of the lighted tip. The lens is cylindrical over at least some of its length, and the tip further includes a light source at least partially within the cylindrical lens portion and a mechanical connector at a proximal end if the lighted tip, for connecting the tip to the flexible rod.

Abstract: A lighted tip for a flexible rod includes a tip body having proximal and distal ends, a mechanical connector at the proximal end, a rounded lens connected to the distal end, and a light source that emits light through the rounded lens. The lighted tip defines a transverse through hole to enable connection of a wire to the lighted tip.

Abstract: A lighted tip for a flexible rod includes a tip body having proximal and distal ends, a mechanical connector at the proximal end, a rounded lens connected to the distal end, and a light source that emits light through the rounded lens. The lighted tip defines a transverse through hole to enable connection of a wire to the lighted tip.

Abstract: Various steerable tips may be used with flexible rods to move the tips through a wide assortment of cavities. In one embodiment, a steerable tip is constructed of a rigid tip body having a proximal end, a distal end and a plurality of radially extending fins. Also, at least one of the fins defines a surface through which extends at least one through hole. Also, a proximal connector is operably coupled to the proximal end of the tip body, and the proximal connector is adapted to couple the tip body to a rod. A distal connector is operably coupled to the distal end of the tip body. This permits other accessories to be coupled to the tip.

Abstract: A method of and apparatus for recording information from a master medium onto a slave medium. Analog information on a master medium is reproduced and converted into digital information. The digital information is stored in a digital storage device. The digital information stored in the digital storage device is recovered from the digital storage device and converted from digital information into analog information. The analog information is applied to a recording device for recording the analog information onto a slave medium. Information is recorded in the digital storage device at the same rate as it is recorded on the master medium. Information is recovered from the digital storage device at a faster rate than it is recorded on the master medium and the information is recorded on a slave medium by the recording device at a faster rate than it is recorded on the master medium.