Patents by Inventor John E. Pike

John E. Pike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5127165
    Abstract: The gun sight comprises a cathode ray tube (21) to generate an aiming image and optical means (22,23) to project said generated image into a line of sight through the gun sight. Velocity of movement of the gun sight is sensed by gyros and in response thereto the cathode ray tube (21) generates an aiming image at a location displaced from a sight-stationary position by an amount dependent on the velocity and direction of movement of the gun sight and a predetermined target range.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: July 7, 1992
    Inventors: David H. Polzin, Lynn Jackson, John E. Pike
  • Patent number: 4499293
    Abstract: Prostaglandin (PG.sub.1) derivatives having a 5,6-didehydro feature, for example an enol ether of the formula ##STR1## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.
    Type: Grant
    Filed: July 28, 1977
    Date of Patent: February 12, 1985
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4424350
    Abstract: The present invention relates to 2-decarboxy-2-tetrazolyl-PGI.sub.2 amides, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: January 3, 1984
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4338325
    Abstract: The present invention relates to PGI.sub.2 pharmacologically acceptable salts, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: July 6, 1982
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4337204
    Abstract: The present invention relates to PGI.sub.2 lower alkyl esters, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: June 29, 1982
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4325875
    Abstract: The present invention relates to 2-decarboxy-2-hydroxymethyl-PGI.sub.2 compounds, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: April 20, 1982
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4323673
    Abstract: The present invention relates to 2-decarboxy-2-aminomethyl-PGI.sub.2 compounds, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: April 6, 1982
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4323674
    Abstract: The present invention relates to PGI.sub.2 analogs, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: April 6, 1982
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4323672
    Abstract: The present invention relates to PGI.sub.2 amides, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: April 6, 1982
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4322525
    Abstract: The present invention relates to PGI.sub.2 11,15-ether intermediates, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors. The present invention describes PGI.sub.2 11,15-ether intermediates. These compounds are intermediates for preparing corresponding prostacylcin-type compounds with pharmacological utility, e.g., platelet aggregation inhibitors.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: March 30, 1982
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
  • Patent number: 4069386
    Abstract: Prostaglandin E.sub.1 -type and F.sub.1 -type compounds with a methyl or an ethyl substituent at the C-15 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.
    Type: Grant
    Filed: February 6, 1976
    Date of Patent: January 17, 1978
    Assignee: The Upjohn Company
    Inventors: John E. Pike, William P. Schneider
  • Patent number: 4029691
    Abstract: Prostaglandin A.sub.1 compounds with a methyl or an ethyl substituent at the C-15 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins A.
    Type: Grant
    Filed: December 24, 1975
    Date of Patent: June 14, 1977
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, John E. Pike
  • Patent number: 3984455
    Abstract: This invention is a group of optically active or racemic prostaglandin E.sub.1 analogs of the formula: ##SPC1##Wherein R is an alkyl group containing from one to 8 carbon atoms, inclusive, X is hydrogen or methyl with the proviso that not more than one methyl group can be present in a given side chain, Y and Y' are hydrogen or alkanoyl of one to 12 carbon atoms, inclusive, Z is hydrogen, a hydrocarbyl group of one to 12 carbon atoms, inclusive, or a pharmacologically acceptable cation, and n is 0, 1 or 2. These prostaglandin E.sub.1 analogs are useful for the same pharmacological purposes as PGE.sub.1.
    Type: Grant
    Filed: December 16, 1974
    Date of Patent: October 5, 1976
    Assignee: The Upjohn Company
    Inventors: Philip F. Beal, III, Frank H. Lincoln, Jr., John E. Pike
  • Patent number: 3975404
    Abstract: Intermediates useful for preparing prostaglandin-type compounds with an alkoxy group replacing the hydroxyl at the C-15 position are disclosed. These products are useful for the same pharmacological properties as the unsubstituted prostaglandins.
    Type: Grant
    Filed: February 20, 1975
    Date of Patent: August 17, 1976
    Assignee: The Upjohn Company
    Inventors: Frank H. Lincoln, Jr., John E. Pike, Gilbert A. Youngdale
  • Patent number: 3954832
    Abstract: Prostaglandin E.sub.1 -type, F.sub.1 -type, A.sub.1 -type, and B.sub.1 -type compounds with one or two methyl or ethyl substituents at the C-16 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.
    Type: Grant
    Filed: February 11, 1974
    Date of Patent: May 4, 1976
    Assignee: The Upjohn Company
    Inventors: John E. Pike, William P. Schneider
  • Patent number: 3953499
    Abstract: Prostaglandins E.sub.1 -type and F.sub.1 -type compounds of the formula ##EQU1## wherein R is hydrogen or a hydrocarbyl group containing from 1 to 12 carbon atoms, inclusive, wherein W is ##EQU2## or O =, wherein R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 are hydrogen or alkyl of 1 to 4 carbon atoms, inclusive, provided (1) that at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl (2) that when R.sub.13 is alkyl, at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, and R.sub.14 is alkyl, and (3) that when R.sub.7 is alkyl or thwn R.sub.7 and R.sub.8 are alkyl, at least one of R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl; and the enantiomers and racemic mixtures thereof. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.
    Type: Grant
    Filed: June 14, 1974
    Date of Patent: April 27, 1976
    Assignee: The Upjohn Company
    Inventors: John E. Pike, William P. Schneider
  • Patent number: 3948981
    Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..
    Type: Grant
    Filed: December 18, 1974
    Date of Patent: April 6, 1976
    Assignee: The Upjohn Company
    Inventors: John E. Pike, William P. Schneider
  • Patent number: 3933891
    Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..
    Type: Grant
    Filed: July 8, 1974
    Date of Patent: January 20, 1976
    Assignee: The Upjohn Company
    Inventors: John E. Pike, William P. Schneider
  • Patent number: 3931284
    Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..
    Type: Grant
    Filed: July 8, 1974
    Date of Patent: January 6, 1976
    Assignee: The Upjohn Company
    Inventors: John E. Pike, William P. Schneider
  • Patent number: 3931283
    Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..
    Type: Grant
    Filed: July 8, 1974
    Date of Patent: January 6, 1976
    Assignee: The Upjohn Company
    Inventors: John E. Pike, William P. Schneider