Patents by Inventor John E. Pike
John E. Pike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5127165Abstract: The gun sight comprises a cathode ray tube (21) to generate an aiming image and optical means (22,23) to project said generated image into a line of sight through the gun sight. Velocity of movement of the gun sight is sensed by gyros and in response thereto the cathode ray tube (21) generates an aiming image at a location displaced from a sight-stationary position by an amount dependent on the velocity and direction of movement of the gun sight and a predetermined target range.Type: GrantFiled: September 12, 1990Date of Patent: July 7, 1992Inventors: David H. Polzin, Lynn Jackson, John E. Pike
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Patent number: 4499293Abstract: Prostaglandin (PG.sub.1) derivatives having a 5,6-didehydro feature, for example an enol ether of the formula ##STR1## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.Type: GrantFiled: July 28, 1977Date of Patent: February 12, 1985Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4424350Abstract: The present invention relates to 2-decarboxy-2-tetrazolyl-PGI.sub.2 amides, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.Type: GrantFiled: March 27, 1981Date of Patent: January 3, 1984Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4338325Abstract: The present invention relates to PGI.sub.2 pharmacologically acceptable salts, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.Type: GrantFiled: October 27, 1980Date of Patent: July 6, 1982Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4337204Abstract: The present invention relates to PGI.sub.2 lower alkyl esters, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.Type: GrantFiled: March 27, 1981Date of Patent: June 29, 1982Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4325875Abstract: The present invention relates to 2-decarboxy-2-hydroxymethyl-PGI.sub.2 compounds, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.Type: GrantFiled: March 27, 1981Date of Patent: April 20, 1982Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4323673Abstract: The present invention relates to 2-decarboxy-2-aminomethyl-PGI.sub.2 compounds, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.Type: GrantFiled: March 27, 1981Date of Patent: April 6, 1982Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4323674Abstract: The present invention relates to PGI.sub.2 analogs, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.Type: GrantFiled: March 27, 1981Date of Patent: April 6, 1982Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4323672Abstract: The present invention relates to PGI.sub.2 amides, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.Type: GrantFiled: March 27, 1981Date of Patent: April 6, 1982Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4322525Abstract: The present invention relates to PGI.sub.2 11,15-ether intermediates, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors. The present invention describes PGI.sub.2 11,15-ether intermediates. These compounds are intermediates for preparing corresponding prostacylcin-type compounds with pharmacological utility, e.g., platelet aggregation inhibitors.Type: GrantFiled: October 27, 1980Date of Patent: March 30, 1982Assignee: The Upjohn CompanyInventors: Roy A. Johnson, Frank H. Lincoln, John E. Pike
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Patent number: 4069386Abstract: Prostaglandin E.sub.1 -type and F.sub.1 -type compounds with a methyl or an ethyl substituent at the C-15 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.Type: GrantFiled: February 6, 1976Date of Patent: January 17, 1978Assignee: The Upjohn CompanyInventors: John E. Pike, William P. Schneider
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Patent number: 4029691Abstract: Prostaglandin A.sub.1 compounds with a methyl or an ethyl substituent at the C-15 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins A.Type: GrantFiled: December 24, 1975Date of Patent: June 14, 1977Assignee: The Upjohn CompanyInventors: Gordon L. Bundy, John E. Pike
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Patent number: 3984455Abstract: This invention is a group of optically active or racemic prostaglandin E.sub.1 analogs of the formula: ##SPC1##Wherein R is an alkyl group containing from one to 8 carbon atoms, inclusive, X is hydrogen or methyl with the proviso that not more than one methyl group can be present in a given side chain, Y and Y' are hydrogen or alkanoyl of one to 12 carbon atoms, inclusive, Z is hydrogen, a hydrocarbyl group of one to 12 carbon atoms, inclusive, or a pharmacologically acceptable cation, and n is 0, 1 or 2. These prostaglandin E.sub.1 analogs are useful for the same pharmacological purposes as PGE.sub.1.Type: GrantFiled: December 16, 1974Date of Patent: October 5, 1976Assignee: The Upjohn CompanyInventors: Philip F. Beal, III, Frank H. Lincoln, Jr., John E. Pike
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Patent number: 3975404Abstract: Intermediates useful for preparing prostaglandin-type compounds with an alkoxy group replacing the hydroxyl at the C-15 position are disclosed. These products are useful for the same pharmacological properties as the unsubstituted prostaglandins.Type: GrantFiled: February 20, 1975Date of Patent: August 17, 1976Assignee: The Upjohn CompanyInventors: Frank H. Lincoln, Jr., John E. Pike, Gilbert A. Youngdale
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Patent number: 3954832Abstract: Prostaglandin E.sub.1 -type, F.sub.1 -type, A.sub.1 -type, and B.sub.1 -type compounds with one or two methyl or ethyl substituents at the C-16 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.Type: GrantFiled: February 11, 1974Date of Patent: May 4, 1976Assignee: The Upjohn CompanyInventors: John E. Pike, William P. Schneider
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Patent number: 3953499Abstract: Prostaglandins E.sub.1 -type and F.sub.1 -type compounds of the formula ##EQU1## wherein R is hydrogen or a hydrocarbyl group containing from 1 to 12 carbon atoms, inclusive, wherein W is ##EQU2## or O =, wherein R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 are hydrogen or alkyl of 1 to 4 carbon atoms, inclusive, provided (1) that at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl (2) that when R.sub.13 is alkyl, at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, and R.sub.14 is alkyl, and (3) that when R.sub.7 is alkyl or thwn R.sub.7 and R.sub.8 are alkyl, at least one of R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl; and the enantiomers and racemic mixtures thereof. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.Type: GrantFiled: June 14, 1974Date of Patent: April 27, 1976Assignee: The Upjohn CompanyInventors: John E. Pike, William P. Schneider
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Patent number: 3948981Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..Type: GrantFiled: December 18, 1974Date of Patent: April 6, 1976Assignee: The Upjohn CompanyInventors: John E. Pike, William P. Schneider
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Patent number: 3933891Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..Type: GrantFiled: July 8, 1974Date of Patent: January 20, 1976Assignee: The Upjohn CompanyInventors: John E. Pike, William P. Schneider
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Patent number: 3931284Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..Type: GrantFiled: July 8, 1974Date of Patent: January 6, 1976Assignee: The Upjohn CompanyInventors: John E. Pike, William P. Schneider
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Patent number: 3931283Abstract: Novel methods are disclosed for transforming PGA.sub.2 and 15.beta.-PGA.sub.2 and their acetates, methyl esters, and acetate methyl esters to various prostanoic acids and esters of the PGE.sub.2 and PGF.sub.2.sub..alpha. series. Some of the latter are novel and are useful for the same pharmacological purposes as PGE.sub.2 and PGF.sub.2.sub..alpha..Type: GrantFiled: July 8, 1974Date of Patent: January 6, 1976Assignee: The Upjohn CompanyInventors: John E. Pike, William P. Schneider