Patents by Inventor John E. Roberts

John E. Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10413547
    Abstract: This invention is in the area of improved therapeutic combinations for and methods of treating selected retinoblastoma (Rb)-negative cancers and Rb-negative abnormal cellular proliferative disorders using particular topoisomerase inhibitors and specific cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. In one aspect, the improved treatment of select Rb-negative cancers is disclosed using specific compounds disclosed herein in combination with a topoisomerase I inhibitor.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: September 17, 2019
    Assignee: G1 Therapeutics, Inc.
    Inventors: Jay Copeland Strum, John E. Bisi, Patrick Joseph Roberts, Jessica A. Sorrentino
  • Patent number: 10391543
    Abstract: A single piece pulsed flow wing assembly method providing for horizontal wing manufacture is accomplished using synchronized automated vehicles guided in a predetermined manner to move and, locate wing structure in a plurality of assembly positions. Multi-axis assembly positioning systems (MAPS) are used at each assembly position to support and index components in the wing structure and determinant assembly techniques are used for indexing of the components. Modular automated manufacturing processes employing magnetic assembly clamping, drilling, fastener insertion, and sealant application are employed.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: August 27, 2019
    Assignee: The Boeing Company
    Inventors: Philip W. Boyd, John W. Hall, Clayton L. Munk, James C. Roberts, Michael J. Fant, Richard D. Fiedler, Barry A. Lewis, Samuel R. Dobbs, Gary E. Mansell
  • Publication number: 20190151311
    Abstract: This invention directed to methods for treating select RB-positive cancers and other Rb-positive abnormal cellular proliferative disorders using CDK4/6 inhibitors in specific dosing and combination or alternation regimes. In one aspect, treatments of select RB-positive cancers are disclosed using specific CDK4/6 inhibitors in combination or alternation with a Bruton's tyrosine kinase (BTK) inhibitor.
    Type: Application
    Filed: January 22, 2019
    Publication date: May 23, 2019
    Applicant: G1 Therapeutics, Inc.
    Inventors: Jay Copeland Strum, John E. Bisi, Patrick Joseph Roberts, Jessica A. Sorrentino, Hannah S. White
  • Patent number: 10092749
    Abstract: An AIMD includes a conductive housing, an electrically conductive ferrule with an insulator hermetically sealing the ferrule opening. A conductive pathway is hermetically sealed and disposed through the insulator. A filter capacitor is disposed on a circuit board within the housing and has a dielectric body supporting at least two active and two ground electrode plates interleaved, wherein the at least two active electrode plates are electrically connected to the conductive pathway on the device side, and the at least two ground electrode plates are electrically coupled to either the ferrule and/or the conductive housing. The dielectric body has a dielectric constant less than 1000 and a capacitance of between 10 and 20,000 picofarads. The filter capacitor is configured for EMI filtering of MRI high RF pulsed power by a low ESR, wherein the ESR of the filter capacitor at an MRI RF pulsed frequency or range of frequencies is less than 2.0 ohms.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: October 9, 2018
    Assignee: Greatbatch Ltd.
    Inventors: Robert A. Stevenson, Robert Shawn Johnson, Warren S. Dabney, Thomas Marzano, Richard L. Brendel, Christopher Michael Williams, Holly Noelle Moschiano, Keith W. Seitz, John E. Roberts
  • Publication number: 20180008822
    Abstract: An AIMD includes a conductive housing, an electrically conductive ferrule with an insulator hermetically sealing the ferrule opening. A conductive pathway is hermetically sealed and disposed through the insulator. A filter capacitor is disposed on a circuit board within the housing and has a dielectric body supporting at least two active and two ground electrode plates interleaved, wherein the at least two active electrode plates are electrically connected to the conductive pathway on the device side, and the at least two ground electrode plates are electrically coupled to either the ferrule and/or the conductive housing. The dielectric body has a dielectric constant less than 1000 and a capacitance of between 10 and 20,000 picofarads. The filter capacitor is configured for EMI filtering of MRI high RF pulsed power by a low ESR, wherein the ESR of the filter capacitor at an MRI RF pulsed frequency or range of frequencies is less than 2.0 ohms.
    Type: Application
    Filed: September 14, 2017
    Publication date: January 11, 2018
    Inventors: Robert A. Stevenson, Robert Shawn Johnson, Warren S. Dabney, Thomas Marzano, Richard L. Brendel, Christopher Michael Williams, Holly Noelle Moschiano, Keith W. Seitz, John E. Roberts
  • Patent number: 9764129
    Abstract: An AIMD includes a conductive housing, an electrically conductive ferrule with an insulator hermetically sealing the ferrule opening. A conductive pathway is hermetically sealed and disposed through the insulator. A filter capacitor is disposed on a circuit board within the housing and has a dielectric body supporting at least two active and two ground electrode plates interleaved, wherein the at least two active electrode plates are electrically connected to the conductive pathway on the device side, and the at least two ground electrode plates are electrically coupled to either the ferrule and/or the conductive housing. The dielectric body has a dielectric constant less than 1000 and a capacitance of between 10 and 20,000 picofarads. The filter capacitor is configured for EMI filtering of MRI high RF pulsed power by a low ESR, wherein the ESR of the filter capacitor at an MRI RF pulsed frequency or range of frequencies is less than 2.0 ohms.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: September 19, 2017
    Assignee: Greatbatch Ltd.
    Inventors: Robert A. Stevenson, Robert Shawn Johnson, Warren S. Dabney, Thomas Marzano, Richard L. Brendel, Christopher Michael Williams, Holly Noelle Moschiano, Keith W. Seitz, John E. Roberts
  • Patent number: 9757558
    Abstract: An AIMD includes a conductive housing, an electrically conductive ferrule with an insulator hermetically sealing the ferrule opening. A conductive pathway is hermetically sealed and disposed through the insulator. A filter capacitor is disposed within the housing and has a dielectric body supporting at least two active and two ground electrode plates interleaved, wherein the at least two active electrode plates are electrically connected to the conductive pathway on the device side, and the at least two ground electrode plates are electrically coupled to either the ferrule and/or the conductive housing. The dielectric body has a dielectric constant less than 1000 and a capacitance of between 10 and 20,000 picofarads. The filter capacitor is configured for EMI filtering of MRI high RF pulsed power by a low ESR, wherein the ESR of the filter capacitor at an MRI RF pulsed frequency or range of frequencies is less than 2.0 ohms.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: September 12, 2017
    Assignee: Greatbatch Ltd.
    Inventors: Robert A. Stevenson, Robert Shawn Johnson, Warren S. Dabney, Thomas Marzano, Richard L. Brendel, Christopher Michael Williams, Holly Noelle Moschiano, Keith W. Seitz, John E. Roberts
  • Publication number: 20160263373
    Abstract: An AIMD includes a conductive housing, an electrically conductive ferrule with an insulator hermetically sealing the ferrule opening. A conductive pathway is hermetically sealed and disposed through the insulator. A filter capacitor is disposed on a circuit board within the housing and has a dielectric body supporting at least two active and two ground electrode plates interleaved, wherein the at least two active electrode plates are electrically connected to the conductive pathway on the device side, and the at least two ground electrode plates are electrically coupled to either the ferrule and/or the conductive housing. The dielectric body has a dielectric constant less than 1000 and a capacitance of between 10 and 20,000 picofarads. The filter capacitor is configured for EMI filtering of MRI high RF pulsed power by a low ESR, wherein the ESR of the filter capacitor at an MRI RF pulsed frequency or range of frequencies is less than 2.0 ohms.
    Type: Application
    Filed: May 24, 2016
    Publication date: September 15, 2016
    Inventors: Robert A. Stevenson, Robert Shawn Johnson, Warren S. Dabney, Thomas Marzano, Richard L. Brendel, Christopher Michael Williams, Holly Noelle Moschiano, Keith W. Seitz, John E. Roberts
  • Publication number: 20150217111
    Abstract: An AIMD includes a conductive housing, an electrically conductive ferrule with an insulator hermetically sealing the ferrule opening. A conductive pathway is hermetically sealed and disposed through the insulator. A filter capacitor is disposed within the housing and has a dielectric body supporting at least two active and two ground electrode plates interleaved, wherein the at least two active electrode plates are electrically connected to the conductive pathway on the device side, and the at least two ground electrode plates are electrically coupled to either the ferrule and/or the conductive housing. The dielectric body has a dielectric constant less than 1000 and a capacitance of between 10 and 20,000 picofarads. The filter capacitor is configured for EMI filtering of MRI high RF pulsed power by a low ESR, wherein the ESR of the filter capacitor at an MRI RF pulsed frequency or range of frequencies is less than 2.0 ohms.
    Type: Application
    Filed: April 16, 2015
    Publication date: August 6, 2015
    Inventors: Robert A. Stevenson, Robert Shawn Johnson, Warren S. Dabney, Thomas Marzano, Richard L. Brendel, Christopher Michael Williams, Holly Noelle Moschiano, Keith W. Seitz, John E. Roberts
  • Patent number: 9064640
    Abstract: An EMI filtered terminal assembly including at least one conductive terminal pin, a feedthrough capacitor, and a counter-bore associated with a passageway through the capacitor is described. Preferably, the feedthrough capacitor having counter-drilled or counter-bored holes on its top side is first bonded to a hermetic insulator. The counter-drilled or counter-bore holes in the capacitor provide greater volume for the electro-mechanical attachment between the capacitor and the terminal pin or lead wire, permitting robotic dispensing of, for example, thermal-setting conductive adhesive.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: June 23, 2015
    Assignee: Greatbatch Ltd.
    Inventors: Richard L. Brendel, Jason Woods, Jose Luis Lorente-Adame, Robert A. Stevenson, John E. Roberts, Buehl E. Truex
  • Patent number: 9014808
    Abstract: An RF filter for an active medical device (AMD), for handling RF power induced in an associated lead from an external RF field at a selected MRI frequency or range frequencies includes a capacitor having a capacitance of between 100 and 10,000 picofarads, and a temperature stable dielectric having a dielectric constant of 200 or less and a temperature coefficient of capacitance (TCC) within the range of plus 400 to minus 7112 parts per million per degree centigrade. The capacitor's dielectric loss tangent in ohms is less than five percent of the capacitor's equivalent series resistance (ESR) at the selected MRI RF frequency or range of frequencies.
    Type: Grant
    Filed: February 23, 2014
    Date of Patent: April 21, 2015
    Assignee: Greatbatch Ltd.
    Inventors: Robert A. Stevenson, Christine A. Frysz, Jason Woods, Richard L. Brendel, Robert S. Johnson, Dominick J. Frustaci, Warren S. Dabney, Keith W. Seitz, Thomas Marzano, John E. Roberts, William C. Thiebolt, Christopher M. Williams, Buehl E. Truex
  • Patent number: 8855768
    Abstract: An RF filter for an active medical device (AMD), for handling RF power induced in an associated lead from an external RF field at a selected MRI frequency or range frequencies includes a capacitor having a capacitance of between 100 and 10,000 picofarads, and a temperature stable dielectric having a dielectric constant of 200 or less and a temperature coefficient of capacitance (TCC) within the range of plus 400 to minus 7112 parts per million per degree centigrade. The capacitor's dielectric loss tangent in ohms is less than five percent of the capacitor's equivalent series resistance (ESR) at the selected MRI RF frequency or range of frequencies.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: October 7, 2014
    Assignee: Greatbatch Ltd.
    Inventors: Robert Shawn Johnson, Dominick J. Frustaci, Warren S. Dabney, Robert A. Stevenson, Keith W. Seitz, Christine A. Frysz, Thomas Marzano, Richard L. Brendel, John E. Roberts, William Thiebolt, Christopher M. Williams, Jason Woods, Buehl E. Truex
  • Publication number: 20140168850
    Abstract: An RF filter for an active medical device (AMD), for handling RF power induced in an associated lead from an external RF field at a selected MRI frequency or range frequencies includes a capacitor having a capacitance of between 100 and 10,000 picofarads, and a temperature stable dielectric having a dielectric constant of 200 or less and a temperature coefficient of capacitance (TCC) within the range of plus 400 to minus 7112 parts per million per degree centigrade. The capacitor's dielectric loss tangent in ohms is less than five percent of the capacitor's equivalent series resistance (ESR) at the selected MRI RF frequency or range of frequencies.
    Type: Application
    Filed: February 23, 2014
    Publication date: June 19, 2014
    Applicant: Greatbatch Ltd.
    Inventors: Robert A. Stevenson, Christine A. Frysz, Jason Woods, Richard L. Brendel, Robert S. Johnson, Dominick J. Frustaci, Warren S. Dabney, Keith W. Seitz, Thomas Marzano, John E. Roberts, William C. Thiebolt, Christopher M. Williams, Buehl E. Truex
  • Publication number: 20130286537
    Abstract: An EMI filtered terminal assembly including at least one conductive terminal pin, a feedthrough capacitor, and a counter-bore associated with a passageway through the capacitor is described. Preferably, the feedthrough capacitor having counter-drilled or counter-bored holes on its top side is first bonded to a hermetic insulator. The counter-drilled or counter-bore holes in the capacitor provide greater volume for the electro-mechanical attachment between the capacitor and the terminal pin or lead wire, permitting robotic dispensing of, for example, thermal-setting conductive adhesive.
    Type: Application
    Filed: June 25, 2013
    Publication date: October 31, 2013
    Inventors: Richard L. Brendel, Jason Woods, Jose Luis Lorente-Adame, Robert A. Stevenson, John E. Roberts, Buehl E. Truex
  • Publication number: 20120256704
    Abstract: An RF filter for an active medical device (AMD), for handling RF power induced in an associated lead from an external RF field at a selected MRI frequency or range frequencies includes a capacitor having a capacitance of between 100 and 10,000 picofarads, and a temperature stable dielectric having a dielectric constant of 200 or less and a temperature coefficient of capacitance (TCC) within the range of plus 400 to minus 7112 parts per million per degree centigrade. The capacitor's dielectric loss tangent in ohms is less than five percent of the capacitor's equivalent series resistance (ESR) at the selected MRI RF frequency or range of frequencies.
    Type: Application
    Filed: February 29, 2012
    Publication date: October 11, 2012
    Applicant: GREATBATCH LTD.
    Inventors: Robert Shawn Johnson, Dominick J. Frustaci, Warren S. Dabney, Robert A. Stevenson, Keith W. Seitz, Christine A. Frysz, Thomas Marzano, Richard L. Brendel, John E. Roberts, William Thiebolt, Christopher M. Williams, Jason Woods, Buehl E. Truex
  • Patent number: 6567259
    Abstract: A feedthrough filter capacitor assembly for use in active implantable medical devices and a related process for manufacturing a monolithic ceramic capacitor utilizing dielectric materials having a dielectric constant greater than 7000, and preferably in the range of 8500 to 22,000. In the manufacture of the monolithic ceramic capacitor, one or more Curie point shifters and/or other dopants are added to the dielectric material to optimize the dielectric constant at the human body temperature of 37° C. For manufacturing purposes, dopants may be added to the dielectric material to broaden the Curie point peak or point of maximum dielectric constant thereof. The effect is that when such capacitors and terminal assemblies are utilized in a high-voltage defibrillator circuit of an implantable medical device, the dielectric material is optimized so that during the delivery of high-voltage electrical energy, capacitance value of the capacitor drops substantially.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: May 20, 2003
    Assignee: Greatbatch-Sierra, Inc.
    Inventors: Robert A. Stevenson, Donald K. Haskell, John E. Roberts
  • Publication number: 20030053284
    Abstract: A feedthrough filter capacitor assembly for use in active implantable medical devices and a related process for manufacturing a monolithic ceramic capacitor utilizing dielectric materials having a dielectric constant greater than 7000, and preferably in the range of 8500 to 22,000. In the manufacture of the monolithic ceramic capacitor, one or more Curie point shifters and/or other dopants are added to the dielectric material to optimize the dielectric constant at the human body temperature of 37° C. For manufacturing purposes, dopants may be added to the dielectric material to broaden the Curie point peak or point of maximum dielectric constant thereof. The effect is that when such capacitors and terminal assemblies are utilized in a high-voltage defibrillator circuit of an implantable medical device, the dielectric material is optimized so that during the delivery of high-voltage electrical energy, capacitance value of the capacitor drops substantially.
    Type: Application
    Filed: September 20, 2002
    Publication date: March 20, 2003
    Inventors: Robert A. Stevenson, Donald K. Haskell, John E. Roberts
  • Patent number: 5573094
    Abstract: A ball bearing/freewheel clutch is provided with an inner race member defining an inner race surface; an outer race member defining an outer race surface concentric with said inner race member; and a raceway between said inner and outer races. The inner and outer race members each have a series of short radially oriented sawtooth inclines on their respective inner and outer race surfaces at right angles to said raceway. A plurality of modified ball bearings are disposed in said raceway between said inner and outer race members, such that said modified ball bearings serve to prevent relative rotation of said inner and outer race members in one direction, and to transmit a torque between said inner and outer races. In the preferred embodiment of the invention, said modified ball bearings have flattened poles which engage said sawtooth inclines in one direction of rotation.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: November 12, 1996
    Assignee: GTE Government Systems Corporation
    Inventor: John E. Roberts
  • Patent number: 4932176
    Abstract: A telescopic mast system has a base tube, a plurality of axially movable coaxial inner tubes nestable successively within each other and within the base tube, and a winch supported at the lower end of the base tube with a pair of preferably wire ropes driven thereby for extending and retracting the inner tubes. The base and inner tubes have collars at their respective ends, the collars of adjacent tubes engaging each other to limit extension thereof and to provide additional structural support during application of bending loads on the mast system. The ropes are connected to pulleys mounted near or within tube collars so that the ropes and pulleys are totally enclosed within the mast system. As the winch is rotated in one direction, the ropes axially move the inner tubes from a nested or stowed position within the base tube to a fully vertically extended operational position.
    Type: Grant
    Filed: September 19, 1988
    Date of Patent: June 12, 1990
    Assignee: GTE Government Systems Corporation
    Inventors: John E. Roberts, Jerome L. Hitchcock
  • Patent number: 4912994
    Abstract: A linkage device connectable between adjacent ends of a tubular support member and payload member is adapted to rotate the payload member through approximately 180.degree. about the end of the support member between inoperative and operative positions by movement of an actuating rod longitudinally within the tubular member. The linkage device comprises first and second frames secured to adjacent ends of the members and four bars pivotally connected at opposite ends to corners of the frames, the first pair of bars extending within the frames and the second pair extending outside the frames. The actuating rod is connected to the first pair of bars and rotates them about their pivotal connection to the first frame when the rod is moved longitudinally within the tubular member. Both pairs of bars cause the payload member to rotate about the end of the support member through 180.degree. and into an operative position in longitudinal alignment with the support member.
    Type: Grant
    Filed: March 6, 1989
    Date of Patent: April 3, 1990
    Assignee: GTE Government Systems Corporation
    Inventor: John E. Roberts