Abstract: A multi-light glass block panel assembly adapted for pre-fab manufacture and application. A grid of perimeter and interior frame members having grooved interior faces seats in the grooves a plurality of glass blocks, one in each opening of the grid. A sealant such as a silicone sealant is interposed between the blocks and the adjacent frame members. In manufacture, the perimeter frame members are pulled tightly against the blocks, thereby securing them in their respective openings.