Abstract: This invention relates generally to compounds that are glucuronidase inhibitors. The glucuronidase inhibitors include phenoxy thiophene sulfonamides, and other compounds such as pyridine sulfonyls, benzene sulfonyls, thiophene sulfonyls, thiazole sulfonyls, thiophene carbonyls, and thiazole carbonyls. These compounds include nialamide, isocarboxazid, phenelzine, amoxapine, loxapine and mefloquine. Also compositions including one or more of such compounds for use in inhibiting glucuronidase and methods of using one or more of such compounds for selective inhibition of bacterial ?-glucoronidase. These compounds may be used as a co-drug in combination with the anticancer drug CPT-11. Also a method for screening compounds to determine their usefulness in reducing diarrhea associated with irinotecan chemotherapy.

Abstract: This invention relates generally to compounds that are glucuronidase inhibitors. The glucuronidase inhibitors include phenoxy thiophene sulfonamides, and other compounds such as pyridine sulfonyls, benzene sulfonyls, thiophene sulfonyls, thiazole sulfonyls, thiophene carbonyls, and thiazole carbonyls. These compounds include nialamide, isocarboxazid, phenelzine, amoxapine, loxapine and mefloquine. Also compositions including one or more of such compounds for use in inhibiting glucuronidase and methods of using one or more of such compounds for selective inhibition of bacterial ?-glucoronidase. These compounds may be used as a co-drug in combination with the anticancer drug CPT-11. Also a method for screening compounds to determine their usefulness in reducing diarrhea associated with irinotecan chemotherapy.

Abstract: The invention relates to a cable cleaning and lubricating system comprising a chamber (5) adapted to surround a section of a cable (4) to be cleaned and to be displaced relative to the cable (4), nozzles (7) within the chamber (5) for directing jets of relatively high pressure cleaning liquid onto the surface of the cable (4), sealing means (6) at both ends of the chamber (5) and adapted to contact the cable (4), the chamber (5) being provided with an outlet (10) which is in communication with a vacuum pump for reducing the pressure in the chamber (5) to a value below atmospheric pressure. The invention relates furthermore to the use of this system for cleaning and lubricating a cable (FIG. 1).

Abstract: The features of the invention are illustrated in a preferred embodiment which provides novel apparatus for carrying out the method of automatically beveling the edges or rims of television picture tube funnel or viewing panel components. The components are delivered to an input station from which they are successively transferred to an edge beveling station. Each component is clamped at the beveling station with the rim at a predetermined height. The rim edges are contacted with edge beveling means also located to bevel at the same predetermined height. The edge beveling means and the rim are moved with respect to each other at the predetermined height until the beveling is completed to obtain a uniform bevel completely around the rim. The completion of the beveling operation is sensed to release the clamping of the component at the beveling station and the beveled component is transferred to a discharge station.