Patents by Inventor John E. Skonier

John E. Skonier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6372215
    Abstract: The invention provides antibodies and other binding agents that bind specifically to SRCR domains of human CD6 (hCD6) and have advantageous properties, including the capacity to substantially inhibit binding of activated leukocyte adhesion molecule (ALCAM) to hCD6. The binding agents of the invention are useful, inter alia, in methods for screening peptides and drugs that also bind to hCD6 and/or modulate ALCAM binding to hCD6, as well as in diagnostic and therapeutic methods for management and treatment of inflammatory and autoimmune diseases.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: April 16, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gary C. Starling, Anthony W. Siadak, Michael A. Bowen, Alejandro A. Aruffo, Jurgen Bajorath, Dale L. Bodian, John E. Skonier
  • Patent number: 5444164
    Abstract: A new TGF-.beta. induced gene and protein is described. Treatment of TGF-.beta. growth arrested cells induces the production of a novel gene which encodes a 683 amino acid protein, designated BIG-H3, that contains four homologous repeat regions and which may represent a cell surface recognition molecule. This gene and protein is induced in mammalian cells, and specifically human cells, upon treatment with TGF-.beta., and is shown to inhibit the growth of tumor cells.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: August 22, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Anthony F. Purchio, John E. Skonier, Michael G. Neubauer