Abstract: A compound having the following structure of Formula (IV): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: Methods, systems, and devices for adjusting a refresh rate during a self-refresh state are described. A memory system may enter a self-refresh state and execute a first set of refresh operations on a set of rows of memory cells at the memory system according to a first rate. The memory system may determine, based on executing the first set of refresh operations, that a counter associated with the set of refresh operations satisfies a threshold for a second time while the memory system is in the self-refresh state. In response to the counter satisfying the threshold for the second time, a flip-flop circuit at the memory system may modify an output of the flip-flop circuit and the memory system may decrease the rate for executing the refresh operations to a second rate based on the modified output of the flip-flop circuit.

Abstract: A biopsy device may include a first jaw having a first distal tip configured to pierce tissue, and a second jaw movable relative to the first jaw between a closed configuration where the first jaw and the second jaw are axially aligned, and an open configuration where the first jaw and the second jaw are offset from one another, the second jaw having a second distal tip proximal to the first distal tip in the closed configuration.

Abstract: An ultrasonic instrument includes a body, an actuation assembly, a shaft assembly, and an end effector. The actuation assembly includes an activation member that is operable to move in a first direction to select a mode of operation. The shaft assembly extends distally from the body and includes an acoustic waveguide. The end effector includes an ultrasonic blade that is in acoustic communication with the acoustic waveguide. The activation member is operable to move in a second direction to activate the end effector in a mode of operation selected by movement of the activation member in the first direction.

Abstract: In some embodiments, an apparatus comprises a media module and a modification module included in an embedded appliance. The media module is configured to receive a first media signal associated with a first input port of the embedded appliance and a second media signal associated with a second input port of the embedded appliance. The media module is configured to identify a first set of media signal parameters based on the first media signal. The modification module is configured to receive a modification instruction associated with a session format having a second set of media signal parameters different from the first set of media signal parameters. The modification module is configured to modify the first media signal based on the first set of media signal parameters and the modification instruction to produce a first modified media signal in the session format and having the second set of media signal parameters.

Abstract: A computerized method analyzes proposed orders for network sites and generates associated order recommendations. A system configuration order (SCO) manager receives a proposed order from an ordering platform and generates a proposed site configuration using the proposed order and a current site configuration of the site. In some examples, the current site configuration is obtained from a network configuration manager associated with the site. The SCO manager generates a recommended site configuration using a configuration recommendation model and the proposed site configuration as input to the configuration recommendation model. A component difference between the recommended site configuration and the proposed site configuration is identified and an order recommendation is generated using the identified component difference. The generated order recommendation is then provided to the ordering platform.

Abstract: A grinding head unit mountable in a planetary disk of a surface grinding machine generally including a housing mountable on the planetary disk, a holder supported on the housing and a surface grinding member detachably connectable to the holder wherein the holder is provided with a recess and the holder is provided with a portion receivable within such recess.

Abstract: A surface grinding machine generally consisting of a drive means provided with an output shaft; a planetary disk mounted on the shaft; and at least two grinding head units mounted on the planetary disk, each including a housing mounted on the planetary disk, a shaft having a flange portion, journaled in the unit housing, resilient means interposed between the housing and the flange portion of the unit shaft and a disk provided with a grit surface disposed on an outer side of the flange portion of the unit shaft.

Abstract: A grinding head unit mountable in a planetary disk of a surface grinding machine generally including a housing mountable on the planetary disk, a holder supported on the housing and a surface grinding member detachably connectable to the holder wherein the holder is provided with a recess and the holder is provided with a portion receivable within such recess.

Abstract: A surface grinding machine generally consisting of a drive means provided with an output shaft; a planetary disk mounted on the shaft; and at least two grinding head units mounted on the planetary disk, each including a housing mounted on the planetary disk, a shaft having a flange portion, journaled in the unit housing, resilient means interposed between the housing and the flange portion of the unit shaft and a disk provided with a grit surface disposed on an outer side of the flange, portion of the unit shaft.

Abstract: A power-efficient, distributed reconfigurable computing system and method are provided. A reconfigurable computing system may include an embedded controller for performing real-time control and initialization and circuitry that supports data-flow driven execution of processing phases. The circuitry may include processing elements such as RAM-based field programmable gate array devices and direct memory access engines. The processing elements can be configured for one or more functions or operations of a program and then reconfigured for other functions or operations of the program. The processing elements can be configured or reconfigured to construct a desired sequence of operations in real-time. A processing element may be divided into slots, each of which includes a substantially similar amount of resources. A processing element includes one or more wrappers, and a wrapper may occupy a slot or a group of slots. Layered software architecture separates control software from implementation software.

Abstract: A sighting device may be used to identify and/or locate remote celestial and/or terrestrial objects. The device may include one or more gravity sensors and one or more magnetic sensors that are used to determine the direction in which the device is aimed. Once the aiming direction is determined, a device control system may be used to access an object database and determine a likely candidate object on or near the aiming direction. The device may include capability to output audiovisual information related to the object. The device may be configured to provide audiovisual commands that direct the user to point the device toward a desired or target location, thereby allowing the user to locate objects with unknown positions. The device may be used as a control system for telescopes and other optical devices.

Abstract: A fully automated telescope system is able to be fully operable in both Alt-Az and polar configurations. In either configuration, the telescope aligns itself to the celestial coordinate system following a simplified initialization procedure during which the telescope tube is first pointed north and then pointed towards a user's horizon. A command processor, under application software program control orients the telescope system with respect to the celestial coordinate system given the initial directional inputs. The initial telescope orientation may be further refined by initially inputting a geographical location indicia, or by shooting one or two additional celestial objects. Once the telescope's orientation with respect to the celestial coordinate system is established, the telescope system will automatically move to and track any desired celestial object without further alignment invention by a user.

Abstract: A fully automated telescope system is able to be fully operable in both Alt-Az and polar configurations. In either configuration, the telescope aligns itself to the celestial coordinate system following a simplified initialization procedure during which the telescope tube is first pointed north and then pointed towards a user's horizon. A command processor, under application software program control orients the telescope system with respect to the celestial coordinate system given the initial directional inputs. The initial telescope orientation may be further refined by initially inputting a geographical location indicia, or by shooting one or two additional celestial objects. Once the telescope's orientation with respect to the celestial coordinate system is established, the telescope system will automatically move to and track any desired celestial object without further alignment invention by a user.

Abstract: A telescope system facilitates easy upgrading from friction lock mounting to manual worm drive, and from manual worm drive to motor drive. Vibration isolation provides a steady field of view for enhanced observation and photography. A telescope mount facilitates enhanced below the horizon and zenith viewing. A tripod has detents which hold the legs thereof in a deployed position during handling of the tripod. A cam lock reliably maintains a desired length of telescoping tripod legs.

Abstract: A telescope system facilitates easy upgrading from friction lock mounting to manual worm drive, and from manual worm drive to motor drive. Vibration isolation provides a steady field of view for enhanced observation and photography. A telescope mount facilitates enhanced below the horizon and zenith viewing. A tripod has detents which hold the legs thereof in a deployed position during handling of the tripod. A cam lock reliably maintains a desired length of telescoping tripod legs.

Abstract: A seat suspended between two crutches in the manner of a sling, to provide the user of the crutches with a place to rest. The seat is attached to both crutches of a pair of crutches used by an individual needing crutches. The seat is attached by one or more adjustable straps and/or release clips. The seat allows the user to rest his body weight on the seat thereby relieving the arms of the user without placing weight on the lower limbs. The crutches are fully usable in the normal manner for walking while the seat is attached and suspended from the crutches. The seat hangs below and behind the user when the crutches are used by the user for walking. The feet of the crutched are placed adjacent one another, while the tops of the crutches are spread apart to raise the seat into a usable height, while providing a stable base for supporting the user. The crutches are then angled slightly forward with the tops of the crutches in front of the user and the crutch feet behind the user.

Abstract: A fully automated telescope system is able to be fully operable in both Alt-Az and polar configurations. In either configuration, the telescope aligns itself to be celestial coordinate system following a simplified initialization procedure during which the telescope tube is first pointed north and then pointed towards a user's horizon. A command processor, under application software program control orients the telescope system with respect to the celestial coordinate system given the initial directional inputs. The initial telescope orientation may be further refined by initially inputting a geographical location indicia, or by shooting one or two additional celestial objects. Once the telescope's orientation with respect to the celestial coordinate system is established, the telescope system will automatically move to and track any desired celestial object without further alignment invention by a user.

Abstract: A seat suspended between two crutches in the manner of a sling, to provide the user of the crutches with a place to rest. The seat is attached to both crutches of a pair of crutches used by an individual needing crutches. The seat is attached by one or more adjustable straps and/or release clips. The seat allows the user to rest his body weight on the seat thereby relieving the arms of the user without placing weight on the lower limbs. The crutches are fully usable in the normal manner for walking while the seat is attached and suspended from the crutches. The seat hangs below and behind the user when the crutches are used by the user for walking. The feet of the crutched are placed adjacent one another, while the tops of the crutches are spread apart to raise the seat into a usable height, while providing a stable base for supporting the user. The crutches are then angled slightly forward with the tops of the crutches in front of the user and the crutch feet behind the user.