Patents by Inventor John E. Starrett

John E. Starrett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphate prodrugs of fluoroxindoles
    Patent number: 6930100
    Abstract: The present invention provides novel phosphate derivatives having the general Formula I wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer and A, B, R1, R2, R3, R4, m and n are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of potassium channels.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: August 16, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kevin W. Gillman, Piyasena Hewawasa, William D. Schmitz, Omar D. Lopez, John E. Starrett, David P. Provencal
  • Phosphate prodrugs of fluorooxindoles
    Publication number: 20030195169
    Abstract: The present invention provides novel phosphate derivatives having the general Formula I 1
    Type: Application
    Filed: March 20, 2003
    Publication date: October 16, 2003
    Inventors: Kevin W. Gillman, Piyasena Hewawasa, William D. Schmitz, Omar D. Lopez, John E. Starrett, David P. Provencal
  • Thiophenyl triazol-3-one derivatives as smooth muscle relaxants
    Patent number: 6613786
    Abstract: The present invention provides novel [1,2,4]triazole-3-one derivatives having the general formula (I) wherein: Q is  and R1, R2, R3, R4, R5 and R6 are as defined herein or a nontoxic pharmaceutically acceptable salt or solvate thereof which are smooth muscle relaxants and useful in treating disorders responsive to relaxation of smooth muscle such as asthma, irritable bowel syndrome, male erectile dysfunction and urinary incontinence.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: September 2, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Piyasena Hewawasam, John E. Starrett, Dalton King, Li-Quang Sun, Nicholas J. Lodge
  • Thiophenyl triazol-3-one derivatives as smooth muscle relaxants
    Publication number: 20030144333
    Abstract: The present invention provides novel [1,2,4]triazole-3-one derivatives having the general formula (I) 1
    Type: Application
    Filed: October 8, 2002
    Publication date: July 31, 2003
    Inventors: Piyasena Hewawasam, John E. Starrett, Dalton King, Li-Quang Sun, Nicholas J. Lodge
  • Selective maxi-K potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof
    Publication number: 20020045566
    Abstract: The present invention describes calcium sensitive and selective maxi-K potassium channel opener/activator compounds that function to open maxi-K channels under conditions of high intracellular calcium concentrations, and which do not significantly affect the opening of maxi-K channel proteins under conditions of low or physiologically normal intracellular calcium concentrations. Methods of assaying for and using such compounds are also provided. According to the invention, whole cell voltage patch-clamp studies newly demonstrated that the ability of opener compounds, e.g., fluoro-oxindoles and chloro-oxindoles, to open maxi-K channels was sensitive to the intracellular Ca2+ concentration ([Ca2+])i, i.e., more channels opened at more negative potentials.
    Type: Application
    Filed: October 12, 2001
    Publication date: April 18, 2002
    Inventors: Valentin K. Gribkoff, Debra J. Post-Munson, Sarita W. Yeola, Christopher G. Boissard, Piyasena Hewawasam, John E. Starrett
  • Carbamate derivatives of diaryl 1,3,4-oxadiazolone
    Patent number: 6297241
    Abstract: The present invention provides novel carbamate oxadiazolone derivatives having the general formula wherein R1 and R2 are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of the large conductance calcium-activated potassium channels.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: October 2, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Piyasena Hewawasam, Xi Chen, John E. Starrett