Patents by Inventor John E. Tavis

John E. Tavis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of nucleotidyltransferase superfamily enzymes as antibiotics
    Patent number: 12502362
    Abstract: In one aspect, the present disclosure provides methods of treating a bacterial infection using an inhibitor of the nucleotidyltransferase superfamily enzyme. In some embodiments, the compounds have one of the following formulas (I), (II), (III), or (IV) wherein R1, R2, and R3 are as defined herein or a pharmaceutically acceptable salt thereof. The compounds may be used to treat a bacterial infection including an infection of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: December 23, 2025
    Assignees: Saint Louis University, United States Government as Represented by the Department of Veterans Affairs, Research Foundation of the City University of New York
    Inventors: Feng Cao, John E. Tavis, Maureen J. Donlin, Marvin J. Meyers, Ryan P. Murelli, Cari Orth, Bahaa Elgendy
  • INHIBITORS OF NUCLEOTIDYLTRANSFERASE SUPERFAMILY ENZYMES AS ANTIBIOTICS
    Publication number: 20200147086
    Abstract: In one aspect, the present disclosure provides methods of treating a bacterial infection using an inhibitor of the nucleotidyltransferase superfamily enzyme. In some embodiments, the compounds have one of the following formulas (I), (II), (III), or (IV) wherein R1, R2, and R3 are as defined herein or a pharmaceutically acceptable salt thereof. The compounds may be used to treat a bacterial infection including an infection of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species.
    Type: Application
    Filed: May 16, 2018
    Publication date: May 14, 2020
    Applicants: Saint Louis University, U.S. Department of Veterans Affairs, Research Foundation of the City University of New York
    Inventors: Feng CAO, John E. TAVIS, Maureen J. DONLIN, Marvin J. MEYERS, Ryan P. MURELLI, Cari ORTH, Bahaa ELGENDY
  • Sequence covariance networks, methods and uses therefor
    Patent number: 8793074
    Abstract: Methods of identifying targets for designing a therapeutic agent are disclosed. These methods comprise: determining an amino acid sequence of one or more polypeptides of each isolate of a plurality of isolates of a biological system; identifying covariance pairs of amino acid residues; establishing a network comprising the covariance pairs; and identifying one or more hub residue positions, wherein a hub residue position comprises a target for designing a therapeutic agent if the hub residue position has a rank order in the 40th percentile or greater. In other aspects, methods are disclosed for selecting a therapy for an infectious disorder.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: July 29, 2014
    Assignee: Saint Louis University
    Inventors: Rajeev Aurora, Maureen J. Donlin, John E. Tavis
  • SEQUENCE COVARIANCE NETWORKS, METHODS AND USES THEREFOR
    Publication number: 20080318207
    Abstract: Methods of identifying targets for designing a therapeutic agent are disclosed. These methods comprise: determining an amino acid sequence of one or more polypeptides of each isolate of a plurality of isolates of a biological system; identifying covariance pairs of amino acid residues; establishing a network comprising the covariance pairs; and identifying one or more hub residue positions, wherein a hub residue position comprises a target for designing a therapeutic agent if the hub residue position has a rank order in the 40th percentile or greater. In other aspects, methods are disclosed for selecting a therapy for an infectious disorder.
    Type: Application
    Filed: June 23, 2008
    Publication date: December 25, 2008
    Applicant: Saint Louis University
    Inventors: Rajeev Aurora, Maureen J. Donlin, John E. Tavis