Patents by Inventor John E. Wehrli
John E. Wehrli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6996473Abstract: A secondary compound library produced by a method of screening a compound library or portion thereof by absorption is provided. The method includes a step (i) that screens a primary compound library or portion thereof having a plurality of test samples containing isolated compounds or isolated mixtures of compounds per test sample by generating an in vivo absorption profile for each of the test samples from initial dose data and from in vitro bioavailability data comprising permeability and solubility data for each of the test samples, wherein the absorption profile includes at least one of rate of absorption, extent of absorption, and concentration of a test sample. Step (ii) produces a secondary compound library that includes at least one compound from the primary compound library having a desired absorption profile.Type: GrantFiled: November 21, 2001Date of Patent: February 7, 2006Assignee: Lion Bioscience AGInventors: George M. Grass, Glen D. Leesman, Daniel A. Norris, Patrick J. Sinko, John E. Wehrli
-
Patent number: 6647358Abstract: The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data.Type: GrantFiled: May 26, 1999Date of Patent: November 11, 2003Assignee: Lion Bioscience AGInventors: George M. Grass, Glen D. Leesman, Daniel A. Norris, Patrick J. Sinko, John E. Wehrli
-
Patent number: 6542858Abstract: The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver: The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data.Type: GrantFiled: May 26, 1999Date of Patent: April 1, 2003Assignee: Lion Bioscience AGInventors: George M. Grass, Glen D. Leesman, Daniel A. Norris, Patrick J. Sinko, John E. Wehrli
-
Publication number: 20020061540Abstract: A secondary compound library produced by a method of screening a compound library or portion thereof by absorption is provided. The method includes a step (i) that screens a primary compound library or portion thereof having a plurality of test samples containing isolated compounds or isolated mixtures of compounds per test sample by generating an in vivo absorption profile for each of the test samples from initial dose data and from in vitro bioavailability data comprising permeability and solubility data for each of the test samples, wherein the absorption profile includes at least one of rate of absorption, extent of absorption, and concentration of a test sample. Step (ii) produces a secondary compound library that includes at least one compound from the primary compound library having a desired absorption profile.Type: ApplicationFiled: November 21, 2001Publication date: May 23, 2002Applicant: Lion Bioscience AGInventors: George M. Grass, Glen D. Leesman, Daniel A. Norris, Patrick J. Sinko, John E. Wehrli
-
Publication number: 20020035459Abstract: The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data.Type: ApplicationFiled: May 26, 1999Publication date: March 21, 2002Inventors: GEORGE M. GRASS, GLEN D. LEESMAN, DANIEL A. NORRIS, PATRICK J. SINKO, JOHN E. WEHRLI
-
Publication number: 20020013662Abstract: The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data.Type: ApplicationFiled: May 26, 1999Publication date: January 31, 2002Inventors: GEORGE M. GRASS, GLEN D. LEESMAN, DANIEL A. NORRIS, PATRICK J. SINKO, JOHN E. WEHRLI
-
Publication number: 20020010550Abstract: The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data.Type: ApplicationFiled: May 26, 1999Publication date: January 24, 2002Inventors: GEORGE M. GRASS, GLEN D. LEESMAN, DANIEL A. NORRIS, PATRICK J. SINKO, JOHN E. WEHRLI
-
Publication number: 20010041964Abstract: The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data.Type: ApplicationFiled: May 26, 1999Publication date: November 15, 2001Inventors: GEORGE M. GRASS, GLEN D. LEESMAN, DANIEL A. NORRIS, PATRICK J. SINKO, JOHN E. WEHRLI