Patents by Inventor John E. Wiktorowicz
John E. Wiktorowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10168337Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules used to diagnose patient with risk of DHF. More particularly, the invention provides plasma biomarkers including complement factor D to complement factor H (FactorD/FactorH) ratio and levels of one or more of IL2, desmoplakin, and high molecular weight albumin, which are used to detect risk of developing DHF.Type: GrantFiled: June 6, 2012Date of Patent: January 1, 2019Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Allan Brasier, Adrian Recinos, John E. Wiktorowicz, Heidi Spratt, Hyunsu Ju, Nikos Vasilakis, Ernesto E. T. Marquez, Marli Tenorio, Laura H. V. G. Gil, Eduardo Nascimento
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Patent number: 10126309Abstract: The present invention provides methods for detecting, analyzing, and identifying biomolecules used to identifying patient with dengue-like symptom who are at risk of DHF. The inventive method comprises detecting in a sample from a subject dengue infected patient one or more biomarkers selected from the group consisting of IL-10, fibrinogen, C4A, immunoglobulin, tropomyosin, and three isoforms of albumin, and which are used in a predictive MARS model to detect patients with risk of developing DHF.Type: GrantFiled: July 15, 2015Date of Patent: November 13, 2018Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMSInventor: John E. Wiktorowicz
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Patent number: 9696323Abstract: Certain embodiments include methods for assessing a subject having a trypanosome infection for the presence or absence of indications of cardiomyopathy.Type: GrantFiled: September 10, 2015Date of Patent: July 4, 2017Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Allan Brasier, John E. Wiktorowicz, Hyunsu Ju, Nisha Jain Garg
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Publication number: 20160003845Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules used to diagnose patient with risk of DHF. More particularly, the invention provides plasma biomarkers including complement factor D to complement factor H (FactorD/FactorH) ratio and levels of one or more of IL2, desmoplakin, and high molecular weight albumin, which are used to detect risk of developing DHF.Type: ApplicationFiled: June 6, 2012Publication date: January 7, 2016Applicant: The Board of Regent of the University of Texas SystemInventors: Allan Brasier, Adrian Recinos, John E. Wiktorowicz, Heidi Spratt, Hyunsu Ju, Nikos Vasilakis, Ernesto E.T. Marquez, Marli Tenorio, Laura H. V. G. Gil, Eduardo Nascimento
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Publication number: 20150377911Abstract: Certain embodiments include methods for assessing a subject having a trypanosome infection for the presence or absence of indications of cardiomyopathy.Type: ApplicationFiled: September 10, 2015Publication date: December 31, 2015Inventors: Allan BRASSIER, John E. WIKTOROWICZ, Hyunsu JU, Nisha Jain GARG
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Publication number: 20150316562Abstract: The present invention provides methods for detecting, analyzing, and identifying biomolecules used to identifying patient with dengue-like symptom who are at risk of DHF. The inventive method comprises detecting in a sample from a subject dengue infected patient one or more biomarkers selected from the group consisting of IL-10, fibrinogen, C4A, immunoglobulin, tropomyosin, and three isoforms of albumin, and which are used in a predictive MARS model to detect patients with risk of developing DHF.Type: ApplicationFiled: July 15, 2015Publication date: November 5, 2015Inventors: Tadeusz KOCHEL, Josephina Nores GARCIA, Allan BRASIER, Adrian RECINOS, John E. WIKTOROWICZ, Heidi SPRATT, Hyunsu JU
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Patent number: 9103826Abstract: The present invention provides methods for detecting, analyzing, and identifying biomolecules used to identifying patient with dengue-like symptom who are at risk of DHF. The inventive method comprises detecting in a sample from a subject dengue infected patient one or more biomarkers selected from the group consisting of IL-10, fibrinogen, C4A, immunoglobulin, tropomyosin, and three isoforms of albumin, and which are used in a predictive MARS model to detect patients with risk of developing DHF.Type: GrantFiled: June 6, 2012Date of Patent: August 11, 2015Assignee: The Board of Regents of the University of Texas SystemInventors: Tadeusz Kochel, Josefina Nores Garcia, Allan Brasier, Adrian Recinos, John E. Wiktorowicz, Heidi Spratt, Hyunsu Ju
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Publication number: 20130004473Abstract: The present invention provides methods for detecting, analyzing, and identifying biomolecules used to identifying patient with dengue-like symptom who are at risk of DHF. The inventive method comprises detecting in a sample from a subject dengue infected patient one or more biomarkers selected from the group consisting of IL-10, fibrinogen, C4A, immunoglobulin, tropomyosin, and three isoforms of albumin, and which are used in a predictive MARS model to detect patients with risk of developing DHF.Type: ApplicationFiled: June 6, 2012Publication date: January 3, 2013Applicant: The Board of Regents of the University of Texas SystemInventors: Tadeusz Kochel, Josefina Nores Garcia, Allan Brasier, Adrian Recinos, John E. Wiktorowicz, Heidi Spratt, Hyunsu Ju
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Publication number: 20030180449Abstract: Methods for controlled application of a composition gradient to a surface, via controlled targeting of droplets of different solutions to a surface region, are disclosed. The methods are especially useful for delivering a gradient of first and second solutions to a microchannel within a microchannel device, by targeting droplets of the different solutions to a surface region within or adjacent an opening of the microchannel.Type: ApplicationFiled: December 17, 2002Publication date: September 25, 2003Inventors: John E. Wiktorowicz, Yefim M. Raysberg, Xianmin Kwauk
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Patent number: 6214191Abstract: Disclosed are an apparatus, system, and method for two dimensional electrophoresis of analytes of interest, particularly polypeptides. The apparatus includes a sample separation cavity comprising (1) an electrophoresis region located along an upper portion of the cavity for performing charge and/or size-based electrophoresis in a first dimension along the upper portion, and (2) below the electrophoresis region, a second electrophoresis region for performing electrophoresis in a second dimension in a direction substantially perpendicular to the first dimension. In one preferred embodiment, the second electrophoresis region contains an isoelectric focusing region containing a continuous pKa gradient immobilized on at least one of the major opposing surfaces of the cavity.Type: GrantFiled: November 23, 1999Date of Patent: April 10, 2001Assignee: Lynx Therapeutics, Inc.Inventors: John E. Wiktorowicz, Yefim Raysberg
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Patent number: 6013165Abstract: Disclosed are an apparatus, system, and method for two dimensional electrophoresis of analytes of interest, particularly polypeptides. The apparatus includes a sample separation cavity comprising (1) an electrophoresis region located along an upper portion of the cavity for performing charge and/or size-based electrophoresis in a first dimension along the upper portion, and (2) below the first said electrophoresis region, a second electrophoresis region for performing electrophoresis in a second dimension in a direction substantially perpendicular to the first dimension. In one preferred embodiment, the second electrophoresis region contains an isoelectric focusing region containing a continuous pKa gradient immobilized on at least one of the major opposing surfaces of the cavity.Type: GrantFiled: May 22, 1998Date of Patent: January 11, 2000Assignee: Lynx Therapeutics, Inc.Inventors: John E. Wiktorowicz, Yefim Raysberg
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Patent number: 5264101Abstract: A capillary tube with a charged inner surface for use in capillary electrophoresis and methods. The tube is filled with an electrolyte solution containing 0.05-30% weight/weight of a hydrophilic polymer which is characterized by (A) a molecular weight of 20-5,000 kilodaltons, and (B) a charge between 0.01 and 1.0% as measured by the molar percent of charged monomer subunits to the total polymer subunits, where said charged monomer subunits have the charge opposite to the wall charge at a selected electrophoresis pH.Type: GrantFiled: May 1, 1992Date of Patent: November 23, 1993Assignee: Applied Biosystems, Inc.Inventors: David M. Demorest, William E. Werner, John E. Wiktorowicz
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Patent number: 5181999Abstract: A method for achieving desired electroosmotic flow characteristics in a capillary tube having charged surface groups. An electrolyte solution containing a compound effective to stably alter the charge of the tube walls is drawn into and through the tube during while the electroosmotic flow rate in the tube is being monitored, until a desired electroosmotic flow rate is achieved. The method can be used to optimize electrophoretic separation of charged protein or nucleic acid species in a capillary tube, and to produce capillary tubes with desired charge density properties.Type: GrantFiled: April 8, 1991Date of Patent: January 26, 1993Assignee: Applied Biosystems, Inc.Inventor: John E. Wiktorowicz
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Patent number: 5015350Abstract: A method for achieving desired electroosmotic flow characteristics in a capillary tube having charged surface groups. An electrolyte solution containing a compound effective to stably alter the charge of the tube walls is drawn into and through the tube during while the electroosmotic flow rate in the tube is being monitored, until a desired electroosmotic flow rate is achieved. The method can be used to optimize electrophoretic separation of charged protein or nucleic acid species in a capillary tube, and to produce capillary tubes with desired charge density properties.Type: GrantFiled: November 6, 1989Date of Patent: May 14, 1991Assignee: Applied Biosystems, Inc.Inventor: John E. Wiktorowicz