Abstract: The present invention relates to binding molecules (e.g. antibodies) for the treatment of cancer, and related antibody-drug conjugates.

Abstract: The present invention relates to binding molecules (e.g. antibodies) for the treatment of cancer, and related antibody-drug conjugates.

Abstract: A method of forming interconnections between channels and/or chambers for use in a micro-fluidic device. Two planer substrates (usually glass and silicon respectively) having etched channels are bonded together to form volmes where the channels overlap. A manifolding cut is then made through the glass, intersecting glass channels only. An organic solution is passed into cut, and flows through silicon channels. An aqueous solution is passed into cut, and flows through glass channels. The solutions meet in the region, where matter is transferred from one solution to another.

Abstract: A method of forming a fluid tight seal between a first fluid pathway and a second fluid pathway a volume is defined between an outer surface of the first fluid pathway and an inner surface of the second fluid pathway. The surfaces are maintained in a given orientation and distance with respect, one to another, so as to achieve a desired capillaric property therebetween. A quantity of sealant is delivered to a junction region of said surfaces. The sealant is caused or permitted to flow into the defined volume, so as to achieve capillary balance. Only substantially sufficient sealant is delivered to fill the volume. The sealant is then caused or permitted to cure or set.

Abstract: An adaptor for receiving a fluidic device (12) and facilitating connection of the device (12) to a similar device or other object, the device having defined therein at least one fluid pathway (24), the adaptor being capable of receiving fluid from said at least one pathway (24) and having connecting means (28) for connecting to the, or each fluid pathway (24), so as to substantially immobilise the pathway(s) with respect to the device, thereby preventing damage to the pathway(s), the means for connecting each pathway provides a fluid tight seal, so that in use fluid passes to/from the device, without leakage, to a similar device.

Abstract: A gas sensor is described which is particularly well suited as a carbon monoxide (CO) sensor in a self test gas sensor. The sensor includes a number of aspects which may or may not be used in conjunction with one another. A first aspect is an embodiment which reduces electrical interference (or cross-talk) between a test or gas generating cell and a sensing cell. In one embodiment, baffles are provided to prevent cross-talk. In another embodiment a switching circuit ensures that a test gas generator is operational only when the gas sensor is disconnected from a current source. A second aspect is an embodiment which includes an improved wick which is in close proximity with an electrode and ensures electrolyte is always in contact with the electrode. In an alternate embodiment a solid polymer electrolyte is used between the electrodes. A third aspect is an improved catalyst which reduces the reaction energy and thereby renders the sensor more sensitive. The catalyst is also cheaper than platinum.

Abstract: Apparatus for dispensing a predetermined volume of a liquid (18) comprises a reservoir (12) for the liquid, a channel (13) provided with an outlet (16) for conveying the liquid (18) from the reservoir to the outlet, and means for generating a pulse of gas. The apparatus is arranged such that the flow of gas causes a predetermined volume of liquid to be ejected from the outlet. The outlet comprises a pair of openings in the channel which face one another, the liquid being retained between the openings by surface tension in the absence of a flow of gas. The gas flow is directed towards one of said openings in use. The apparatus may be used to dispense volumes of a liquid reagent in the range 1 nl to 2 &mgr;l. The apparatus avoids contamination of the liquid, and dispensing head construction allows devices to be low cost disposable units. The apparatus is less sensitive to liquid viscosity than existing devices.

Abstract: Apparatus for carrying out a process between first and second immiscible fluids, comprises first and second channels defining flow paths, for permitting fluid flow of respective first and second immiscible fluids therethrough. Portions of the flow paths are disposed close to, or adjacent to, one another and communicate with one another to define a region in which, in use, a stable interface between the fluids is formed. One, or more, dimensions of the region are varied along the length of the interface in a direction of fluid flow to compensate for variation in the properties of the fluids during the carrying out of the process and thereby maintain stability of the interface.

Abstract: Apparatus comprising a micro engineered structure and a capillary or other tube and a method for connecting the tube to the structure. The micro engineered structure is composed of at least one substrate 2 in which fluid flow channels 6 are formed, connecting to an aperture 12 into which the tube 14 is inserted. A sealant material is flowed into the aperture around the tube and then hardened in order to seal the tube within the aperture.

Abstract: In order to facilitate diffusive transfer of an entity such as a solute between immiscible fluids and subsequent separation of the liquids without mixing, a method and an apparatus are disclosed and have first and second flow paths carrying first and second immiscible fluids on opposite sides of a foraminous sheet. The height of the apertures in the sheet is not greater than 200 micrometers (measured perpendicular to the width of the sheet and to the direction of fluid flow), and a stable interface is formed between the fluids within each aperture with a significant amount of fluid flow immediately adjacent the interface. Diffusive transfer takes place across the interface, and subsequently the fluids flow away from the region without mixing. The width of the flow paths measured perpendicular to sheet lies between 10 and 500 micrometers. The walls of each aperture may be parallel or tapered.