Patents by Inventor John Edward Murphy

John Edward Murphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor VIII Variants and Methods of Use
    Publication number: 20120142593
    Abstract: A Factor VIII fusion protein or a Factor VIII fusion heterodimer comprising Factor VIII in which an amino acid sequence of a modulator is present in the B-domain, or an amino acid sequence of a modulator replaces some or all of the amino acid sequence of the B-domain is disclosed. Nucleic acids encoding the inventive fusion proteins and fusion heterodimers are also disclosed, as are methods for producing the fusion proteins and fusion heterodimers, pharmaceutical compositions, and methods of treating deficiencies in coagulation with the inventive fusion molecules.
    Type: Application
    Filed: March 24, 2010
    Publication date: June 7, 2012
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Xiao-Yan Zhao, Peter John Kretschmer, Thomas Eugene Thompson, Douglas W. Schneider, John Edward Murphy
  • Application of Anti-Apoptotic Gene Expression in Mammalian Cells for Perfusion Culture
    Publication number: 20100167396
    Abstract: The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell expressing recombinant Factor VIII such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of recombinant Factor VIII by expressing one or more anti-apoptotic polypeptides in a cell such that production of recombinant Factor VIII by the cell is increased. Recombinant cells useful for producing Factor VIII.
    Type: Application
    Filed: April 21, 2007
    Publication date: July 1, 2010
    Applicants: BAYER HEALTHCARE LLC, JOHNS HOPKINS UNIVERSITY
    Inventors: John Edward Murphy, Konstantin Borislavov Konstantinov, John Christopher Thrift, Tarangsri Nivitchanyong, Michael Betenbaugh