Patents by Inventor John Edwin Tavis

John Edwin Tavis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfur and amide tropolone inhibitors of nucleotidyl transferases and uses therefor
    Patent number: 12606529
    Abstract: The present disclosure provides inhibitors of microorganisms including viruses and fungi of the formula (I) or (II) wherein the variables are defined herein. Also provided are methods of treatment using these agents in the treatment of infections of microorganisms such as viruses and fungi.
    Type: Grant
    Filed: May 3, 2020
    Date of Patent: April 21, 2026
    Assignees: Saint Louis University, Research Foundation of the City University of New York
    Inventors: John Edwin Tavis, Lynda Anne Morrison, Maureen Jeanette Donlin, Ryan P. Murelli
  • Inhibitors of and uses thereof
    Patent number: 12357589
    Abstract: The present disclosure provides inhibitors of bunyavirus of the formula: wherein the variables are defined herein. These inhibitors may be used to treat an infection of Rift Valley phlebovirus, hantavirus, and La Crosse virus, or Crimean-Congo Hemorrhagic fever.
    Type: Grant
    Filed: May 13, 2024
    Date of Patent: July 15, 2025
    Assignees: Saint Louis University, National and Kapodistrian University of Athens
    Inventors: John Edwin Tavis, Grigoris Zoidis, Amelia Pinto, James Brien
  • INHIBITORS OF BUNYAVIRIDAE AND USES THEREOF
    Publication number: 20250009686
    Abstract: The present disclosure provides inhibitors of bunyavirus of the formula: wherein the variables are defined herein.
    Type: Application
    Filed: May 13, 2024
    Publication date: January 9, 2025
    Applicants: Saint Louis University, National and Kapodistrian University of Athens
    Inventors: John Edwin TAVIS, Grigoris ZOIDIS, Amelia PINTO, James BRIEN
  • Inhibitors of Bunyaviridae and uses thereof
    Patent number: 12121500
    Abstract: The present disclosure provides inhibitors of bunyavirus of the formula: wherein the variables are defined herein. These inhibitors may be used to treat an infection of Rift Valley phlebovirus, hantavirus, and La Crosse virus, or Crimean-Congo Hemorrhagic fever.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: October 22, 2024
    Assignees: Saint Louis University, Research Foundation of the City University of New York
    Inventors: John Edwin Tavis, Amelia Pinto, James Brien, Ryan Murelli
  • SULFUR AND AMIDE TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES AND USES THEREFOR
    Publication number: 20220348546
    Abstract: The present disclosure provides inhibitors of microorganisms including viruses and fungi of the formula (I) or (II) wherein the variables are defined herein. Also provided are methods of treatment using these agents in the treatment of infections of microorganisms such as viruses and fungi.
    Type: Application
    Filed: May 3, 2020
    Publication date: November 3, 2022
    Applicants: Saint Louis University, Research Foundation of the City University of New York
    Inventors: John Edwin TAVIS, Lynda Anne MORRISON, Maureen Jeanette DONLIN, Ryan P. MURELLI
  • Hydroxylated tropolone inhibitors of nucleotidyl transferases in herpesvirus and Hepatitis B and uses therefor
    Patent number: 11420922
    Abstract: The present disclosure relates to inhibitors of herpesvirus nucleic acid metabolism and inhibitors of Hepatitis B virus. Also provided are methods of treatment using these agents.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: August 23, 2022
    Assignees: Saint Louis University, Research Foundation of the City University of New York
    Inventors: John Edwin Tavis, Lynda Anne Morrison, Ryan P. Murelli
  • INHIBITORS OF BUNYAVIRIDAE AND USES THEREOF
    Publication number: 20210393548
    Abstract: The present disclosure provides inhibitors of bunyavirus of the formula: wherein the variables are defined herein.
    Type: Application
    Filed: May 12, 2021
    Publication date: December 23, 2021
    Applicants: Saint Louis University, Research Foundation of The City University of New York, National and Kapodistrian University of Athens
    Inventors: John Edwin TAVIS, Grigoris ZOIDIS, Amelia PINTO, James BRIEN, Ryan MURELLI
  • Inhibitors of nucleotidyl transferases and uses in herpes and hepatitis viral infections therefor
    Patent number: 11191754
    Abstract: The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula: wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: December 7, 2021
    Assignee: Saint Louis University
    Inventors: John Edwin Tavis, Lynda Anne Morrison, Marvin Meyers
  • Anti-fungal compounds
    Patent number: 10980754
    Abstract: The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: April 20, 2021
    Assignees: SAINT LOUIS UNIVERSITY, RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Maureen J. Donlin, John Edwin Tavis, Ryan Murelli, Marvin J. Meyers
  • INHIBITORS OF NUCLEOTIDYL TRANSFERASES AND USES IN HERPES AND HEPATITIS VIRAL INFECTIONS THEREFOR
    Publication number: 20190365731
    Abstract: The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula: wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.
    Type: Application
    Filed: August 6, 2019
    Publication date: December 5, 2019
    Applicant: Saint Louis University
    Inventors: John Edwin TAVIS, Lynda Anne MORRISON, Marvin MEYERS
  • Inhibitors of HSV nucleotidyl transferases and uses therefor
    Patent number: 10463664
    Abstract: The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents identified.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: November 5, 2019
    Assignee: Saint Louis University
    Inventors: John Edwin Tavis, Lynda Anne Morrison, Marvin J. Meyers
  • ANTI-FUNGAL COMPOUNDS
    Publication number: 20190099385
    Abstract: The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.
    Type: Application
    Filed: April 19, 2017
    Publication date: April 4, 2019
    Applicants: SAINT LOUIS UNIVERSITY, Research Foundation of the City University of New York
    Inventors: Maureen J. DONLIN, John Edwin TAVIS, Ryan MURELLI, Marvin J. MEYERS
  • N-HYDROXYISOQUINOLINEDIONE INHIBITORS OF HBV REPLICATION
    Publication number: 20190070165
    Abstract: In some aspects, the present disclosure provides compounds of the formula: Formula (I) wherein the variables are defined herein are provided, which may be used to inhibit viral replication. In some embodiments, these compounds may be used to treat an infection of hepatitis B virus.
    Type: Application
    Filed: March 16, 2017
    Publication date: March 7, 2019
    Applicants: Saint Louis University, Ecole Nationale Supérieure de Chimie de Lille
    Inventors: John Edwin TAVIS, Philippe COTELLE, Fabrice BAILLY
  • HYDROXYLATED TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES IN HERPESVIRUS AND HEPATITIS B AND USES THEREFOR
    Publication number: 20180297924
    Abstract: The present disclosure relates to inhibitors of herpesvirus nucleic acid metabolism and inhibitors of Hepatitis B virus. Also provided are methods of treatment using these agents.
    Type: Application
    Filed: June 10, 2016
    Publication date: October 18, 2018
    Applicants: Saint Louis University, The City University of New York
    Inventors: John Edwin TAVIS, Lynda Anne MORRISON, Ryan P. MURELLI
  • INHIBITORS OF NUCLEOTIDYL TRANSFERASES AND USE IN HERPES AND HEPATITIS VIRAL INFECTIONS THEREFOR
    Publication number: 20180169083
    Abstract: The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula: wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 21, 2018
    Applicant: Saint Louis University
    Inventors: John Edwin TAVIS, Lynda Anne MORRISON, Marvin MEYERS
  • INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR
    Publication number: 20160296521
    Abstract: The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents identified.
    Type: Application
    Filed: November 25, 2014
    Publication date: October 13, 2016
    Applicant: Saint Louis University
    Inventors: John Edwin TAVIS, Lynda Anne MORRISON, Marvin J. MEYERS
  • GENERALIZED NETWORK THREADING APPROACH FOR PREDICTING A SUBJECT'S RESPONSE TO HEPATITIS C VIRUS THERAPY
    Publication number: 20120283958
    Abstract: Methods for predicting a response of a virus to an antiviral therapy are provided.
    Type: Application
    Filed: April 24, 2012
    Publication date: November 8, 2012
    Applicant: SAINT LOUIS UNIVERSITY
    Inventors: Rajeev Aurora, John Edwin Tavis