Patents by Inventor John Elfar
John Elfar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240058312Abstract: This document relates to methods and materials for treating bone loss. For example, compositions containing 4-aminopy-ridine (4-AP) and/or one or more derivatives of 4-AP can be administered (e.g., systemically administered) to a mammal having bone loss to treat the mammal.Type: ApplicationFiled: January 5, 2022Publication date: February 22, 2024Inventors: Jagadeeshaprasad Mashanipalya Guddadarangaiah, Prem Kumar Govindappa, John Elfar
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Publication number: 20240024216Abstract: This document provides methods and materials for treating hair loss. For example, compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP can be administered to a mammal having hair loss to treat the hair loss (e.g., to promote hair growth). Further more, a method for increasing hair regeneration, wherein said method comprises administering a composition comprising 4-AP or one or more derivatives of 4-AP to a mammal identified as being in need of increased hair regeneration.Type: ApplicationFiled: January 5, 2022Publication date: January 25, 2024Inventors: John Elfar, Jagadeeshaprasad Mashanipalya Guddadarangaiah, Prem Kumar Govindappa
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Publication number: 20230346758Abstract: This document relates to methods and materials for using 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP. For example, a composition containing 4-AP and/or one or more derivatives of 4-AP can be administered (e.g., orally administered) to a mammal to increase a level of bone morphogenetic protein 2 (BMP-2) polypeptides within the mammal. For example, a composition containing 4-AP and/or one or more derivatives of 4-AP can be administered (e.g., orally administered) to a mammal having bone loss to increase the level of BMP-2 within the mammal, thereby treating the mammal's bone loss.Type: ApplicationFiled: April 27, 2023Publication date: November 2, 2023Inventors: Sandeep Moothedath Subrahmanian, Prem Kumar Govindappa, Jagadeeshaprasad Mashanipalya Guddadarangaiah, John Elfar
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Publication number: 20230338346Abstract: This document relates to methods and materials for treating burns. For example, compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP can be administered (e.g., systemically administered) to a mammal having one o more burns to treat the burn(s) (e.g., to promote burn wound healing).Type: ApplicationFiled: April 25, 2023Publication date: October 26, 2023Inventors: Jagadeeshaprasad Mashanipalya Guddadarangaiah, Prem Kumar Govindappa, Mosammat Begom, John Elfar
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Publication number: 20230285299Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.Type: ApplicationFiled: April 14, 2023Publication date: September 14, 2023Applicant: UNIVERSITY OF ROCHESTERInventors: John Elfar, Kuang-Ching Tseng, Mark Noble
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Patent number: 11654110Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.Type: GrantFiled: November 26, 2019Date of Patent: May 23, 2023Assignee: UNIVERSITY OF ROCHESTERInventors: John Elfar, Kuang-Ching Tseng, Mark Noble
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Publication number: 20230058178Abstract: This document relates to methods and materials for treating nerve injuries. For example, thermoresponsive compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP as well as methods for using such thermoresponsive compositions as a delivery system for 4-AP and/or one or more derivatives of 4-AP (e.g., to treat nerve injury) are provided. This document also provides methods and materials for treating a wound (e.g., a skin wound). For example, compositions containing 4-AP and/or one or more derivatives of 4-AP can be administered (e.g., systemically administered) to a mammal having a wound (e.g., a skin wound) to treat the wound (e.g., to promote wound healing).Type: ApplicationFiled: January 21, 2021Publication date: February 23, 2023Inventors: Kristen Manto, John Elfar, Jagadeeshaprasad Mashanipalya Guddadarangaiah, Prem Kumar Govindappa
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Publication number: 20220409774Abstract: This document relates to compositions containing one or more erythropoietin (EPO) polypeptides. For example, this document provides thermoresponsive compositions containing one or more EPO polypeptides and methods for using such thermoresponsive compositions as a delivery system to deliver one or more EPO polypeptides to desired tissue (e.g., to treat a nerve injury and/or a wound). In some cases, thermoresponsive compositions containing one or more EPO polypeptides can be administered (e.g., locally administered) to a mammal having a nerve injury to treat the nerve injury (e.g., to promote wound healing). In some cases, thermoresponsive compositions containing one or more EPO polypeptides can be administered (e.g., locally administered) to a mammal having a wound to treat the wound (e.g., to promote wound healing).Type: ApplicationFiled: April 25, 2022Publication date: December 29, 2022Inventors: Kristen Manto, John Elfar
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Publication number: 20210008164Abstract: This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.Type: ApplicationFiled: June 26, 2020Publication date: January 14, 2021Inventors: John Elfar, Walaa Elfar, Mark Noble
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Patent number: 10695402Abstract: This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.Type: GrantFiled: March 16, 2018Date of Patent: June 30, 2020Assignee: UNIVERSITY OF ROCHESTERInventors: John Elfar, Walaa Elfar, Mark Noble
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Publication number: 20200093746Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.Type: ApplicationFiled: November 26, 2019Publication date: March 26, 2020Applicant: UNIVERSITY OF ROCHESTERInventors: John Elfar, Kuang-Ching Tseng, Mark Noble
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Publication number: 20180264083Abstract: This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.Type: ApplicationFiled: March 16, 2018Publication date: September 20, 2018Applicant: University of RochesterInventors: John Elfar, Walaa Elfar, Mark Noble
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Publication number: 20180256503Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.Type: ApplicationFiled: May 10, 2018Publication date: September 13, 2018Applicant: UNIVERSITY OF ROCHESTERInventors: John Elfar, Kuang-Ching Tseng, Mark Noble
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Patent number: 9993429Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.Type: GrantFiled: March 13, 2014Date of Patent: June 12, 2018Assignee: University of RochesterInventors: John Elfar, Kuang-Ching Tseng, Mark Noble
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Publication number: 20160038419Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.Type: ApplicationFiled: March 13, 2014Publication date: February 11, 2016Applicant: UNIVERSITY OF ROCHESTERInventors: John Elfar, Kuang-Ching Tseng, Mark Noble