Abstract: The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A: The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

Abstract: A dielectric material is provided. The dielectric material includes at least one layer of a substantially continuous phase material. The material is selected from the group consisting of an organic, organometallic, or combination thereof in which the substantially continuous phase material has delocalized electrons.

Abstract: A method and apparatus of processing a user initiated request for information is disclosed. The method may provide receiving a user initiated request including a uniform resource locator (URL) submitted to a web browser application and receiving a response that the URL is an invalid URL that cannot be resolved to a corresponding webpage. The method may also include blocking a subsequent attempt to transmit the user initiated request as a browser modified search request that includes modifications to the user initiated request.

Abstract: A device for changing the temperature of a wafer, the device comprising: a surface that is configured to support the wafer and to exchange heat with the wafer, and a space that is configured to receive at least a distal part of an end effector, which is used to support the wafer from beneath, when the end effector is used to lower the wafer onto the surface, wherein the space extends from or to a side of the device; and wherein the space is configured so that the at least a distal part of the end effector can be withdrawn from the space from the side of the device.

Abstract: A method and apparatus of processing a user initiated request for information is disclosed. The method may provide receiving a user initiated request including a uniform resource locator (URL) submitted to a web browser application and receiving a response that the URL is an invalid URL that cannot be resolved to a corresponding webpage. The method may also include blocking a subsequent attempt to transmit the user initiated request as a browser modified search request that includes modifications to the user initiated request.

Abstract: The present invention relates to antibodies binding to TREM1 and inhibiting its interaction with one or more of its natural ligands. Specific examples of such antibodies are provided. The therapeutic uses of the antibodies and methods of generating such are also provided.

Abstract: A surgical system includes a sleeve defining a passageway. An adapter is removably coupled to the sleeve. The adapter defines a channel. A delivery device includes a distal end positioned in a channel of the adapter. A bone fastener includes a head and a shank defining a cannula. A distal portion of the adapter is positioned in the shank such that the channel is in communication with a cannula of the shank. A plunger is movably disposed in a lumen of the delivery device. The plunger is configured to move a material through the lumen and the channel and into the cannula. Methods and kits are disclosed.

Abstract: A method of forming a film comprises growing, using a deposition system, at least a portion of the film and analyzing, using a RHEED instrument, the at least a portion of the film. Using a computer, data is acquired from the RHEED instrument that is indicative of a stoichiometry of the at least a portion of the film. Using the computer, adjustments to one or more process parameters of the deposition system are calculated to control stoichiometry of the film during subsequent deposition. Using the computer, instructions are transmitted to the deposition system to execute the adjustments of the one or more process parameters. Using the deposition system, the one or more process parameters are adjusted.

Abstract: An exercise apparatus comprises a movable carriage having a generally flat top surface, the carriage being movably mounted on parallel track members of a frame having a head end and a foot end, the carriage having a pair of shoulder stops mounted thereto and plurality of elastic members connected between the foot end and the carriage to elastically bias the carriage toward the foot end of the frame. The apparatus has a movable spring anchor bar and carriage stop assembly comprising an anchor bar with at least one elongated stop member arranged perpendicular to and secured to the anchor bar, the stop member having a carriage stop surface located towards the end of the stop member remote from the anchor bar and the stop member further comprising at least one movable means of engagement with the frame of the exercise apparatus. The anchor bar and stop assembly may easily be moved and readjusted one handed with safety and smooth operation.

Abstract: A surgical instrument comprises a first member including a drive engageable with a first mating surface of a bone fastener. A second member is rotatable relative to the first member and includes an engagement element connectable with a second mating surface of the bone fastener. A part is disposed with the first member and being alternately connectable with an actuator and an adaptor attachable with an image guide. Systems, surgical adaptors, spinal implants and methods are disclosed.

Abstract: A method of forming a film comprises growing, using a deposition system, at least a portion of the film and analyzing, using a RHEED instrument, the at least a portion of the film. Using a computer, data is acquired from the RHEED instrument that is indicative of a stoichiometry of the at least a portion of the film. Using the computer, adjustments to one or more process parameters of the deposition system are calculated to control stoichiometry of the film during subsequent deposition. Using the computer, instructions are transmitted to the deposition system to execute the adjustments of the one or more process parameters. Using the deposition system, the one or more process parameters are adjusted.

Abstract: A modular display support structure is described, the modular display support structure comprising: a substantially vertical structural member including at least one mounting flange, and a receiving recess, the recess extending parallel with, and for a substantial portion of, a longitudinal axis of the structural member; and a mounting member including an interface flange to mate with the receiving recess, and an attachment flange; wherein the attachment flange includes a plurality of attachment apertures for each of a plurality of display panels. A system and method are also described.

Abstract: A method of forming a film comprises growing, using a deposition system, at least a portion of the film and analyzing, using a RHEED instrument, the at least a portion of the film. Using a computer, data is acquired from the RHEED instrument that is indicative of a stoichiometry of the at least a portion of the film. Using the computer, adjustments to one or more process parameters of the deposition system are calculated to control stoichiometry of the film during subsequent deposition. Using the computer, instructions are transmitted to the deposition system to execute the adjustments of the one or more process parameters. Using the deposition system, the one or more process parameters are adjusted.

Abstract: A surgical instrument comprises a first member including a drive engageable with a first mating surface of a bone fastener. A second member is rotatable relative to the first member and includes an element engageable with a second mating surface of the bone fastener. The members are engageable with the bone fastener in a release configuration, an intermediate configuration and a locked configuration. Systems, surgical adaptors, spinal implants and methods are disclosed.

Abstract: Electro-optic modulators and related devices and methods. The method includes forming a silicon dioxide layer on a silicon substrate. The method includes forming a doped silicon layer in or on the silicon dioxide layer. The method includes forming alternating layers of functional transition metal oxides (TMOs) on the doped silicon layer. Design parameters can be optimized to create realizable devices that minimize the energy consumption of, for example, a SrTiO3/LaAlO3 electro-optic modulator while maximizing electro-optic performance (e.g., modulation energies on the order of tens of pJ/bit).

Abstract: Various embodiments provide for systems and techniques for the successful fabrication of metal oxide (TMO)-on-glass layer stacks via direct deposition. The resulting samples feature epitaxial, strontium titanate (STO) or barium titanate (BTO) films on silicon dioxide (SiO2) layers, forming STO- or BTO-buffered SiO2 pseudo-substrates. As the integration of TMO films on silicon rely on an STO or BTO buffer layer, a wide variety of TMO-based integrated devices (e.g., circuits, waveguides, etc.) can be fabricated from the TMO-on-glass platform of the present technology. Moreover, the STO, or the BTO, survives the fabrication process without a corresponding degradation of crystalline quality, as evidenced by various objective measures.

Abstract: A method for treating a spine, the method comprising the steps of: imaging a patient anatomy for registration of anatomical image data and positional tracking of the patient anatomy; selecting an implant strategy for at least one bone fastener; selecting a manipulation strategy for the patient anatomy; determining a post-correction orientation of the patient anatomy according to the implant strategy and the manipulation strategy; imaging the post-correction orientation of the patient anatomy; engaging the at least one bone fastener with vertebral tissue of the patient anatomy according to the implant strategy; and connecting a first implant support to the at least one bone fastener, the first implant support including an adaptor that is movable relative to the first implant support to releasably engage a surgical instrument to distract and/or compress the vertebral tissue according to the manipulation strategy. Surgical instruments, constructs and implants are disclosed.

Abstract: A high-temperature, high-strength, oxidation-resistant cobalt-nickel base alloy is disclosed. The alloy includes, in weight percent: about 3.5 to about 4.9% of Al, about 12.2 to about 16.0% of W, about 24.5 to about 32.0% Ni, about 6.5% to about 10.0% Cr, about 5.9% to about 11.0% Ta, and the balance Co and incidental impurities. A method of making an article having high-temperature strength, cyclic oxidation resistance and corrosion resistance is disclosed. The method includes forming a high-temperature, high-strength, oxidation-resistant cobalt-nickel base alloy as described herein; forming an article from the alloy; solution-treating the alloy by a solution heat treatment; and aging the alloy by providing at least one aging heat treatment at an aging temperature that is less than the gamma-prime solvus temperature, wherein the alloy is configured to form a continuous, protective, adherent oxide layer on an alloy surface upon exposure to a high-temperature oxidizing environment.

Abstract: A pool cover deployment apparatus is provided. A pool cover deployment apparatus for assisting in manual overlay of a pool cover onto a surface of a pool, comprising an elongated member comprising one or more first attachment members affixed to a front side of the elongated member and one or more second attachment members affixed to a back side of the elongated member. The elongated member is coupled to a leading edge of the pool cover via one or more fasteners and the one or more first attachment members. A pulling mechanism and a means of attaching the cover to the pulling mechanism wherein the pulling mechanism is manually employed by a user such that the pool cover is extended over the pool.