Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.

Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.

Abstract: A power supply extracts electrical power from the electro-magnetic field surrounding a high voltage power conductor and conditions the derived input power to provide a stable power source for instrumentation and communications equipment. The communications controller is a local network router that routes serial data traffic to selected communication devices such as an instrumentation processor, a power supply processor, or a maintenance port controller. The router forwards the data to other communications equipment and forwards data from the communicating equipment to an external network providing substantially simultaneous communications between the external network and the instrumentation processor, power supply processor and maintenance port controller.

Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.

Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions.

Abstract: An apparatus for monitoring and measuring the electrical, thermal and mechanical operating parameters of high voltage power conductors. A toroidal shaped housing, which can be mounted onto an energized conductor, contains all of the necessary electrical instruments to monitor the parameters associated with the conductor. Moreover, the housing includes the processing capability to analyze disturbance and fault events based on these parameters.

Abstract: The combination of a temperature sensor and an inclination sensor or the combination of a temperature sensor and a tension monitor properly positioned in conjunction with an energized electrical conductor produces outputs that are dependent on the conductor's average temperature in real time. A transmitter is used to communicate this information in real time to a central location such that up to optimal or maximum power transmission is feasible through the conductor while maintaining a safe clearance to the ground. This allows for close monitoring of thermal expansion resulting from increased load as well as varying environmental conditions.

Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.

Abstract: The combination of a temperature sensor and an inclination sensor or the combination of a temperature sensor and a tension monitor properly positioned in conjunction with an energized electrical conductor produces outputs that are dependent on the conductor's average temperature in real time. A transmitter is used to communicate this information in real time to a central location such that up to optimal or maximum power transmission is feasible through the conductor while maintaining a safe clearance to the ground. This allows for close monitoring of thermal expansion resulting from increased load as well as varying environmental conditions.

Abstract: Maximum transmission line or conductor loading of an overhead transmission line or conductor spanning two transmission line towers is determined by using a sensing device clamped to the overhead transmission line. The sensing device acquires real-time information that is used in an iterative process to determine sag, limiting temperature, maximum current load and minimum clearance of the transmission line or conductor.

Abstract: An apparatus for monitoring and measuring the electrical, thermal and mechanical operating parameters of high voltage power conductors. A toroidal shaped housing, which can be mounted onto an energized conductor, contains all of the necessary electrical instruments to monitor the parameters associated with the conductor. Moreover, the housing includes the processing capability to analyze disturbance and fault events based on these parameters.

Abstract: Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.

Abstract: Maximum transmission line or conductor loading of an overhead transmission line or conductor spanning two transmission line towers is determined by using a sensing device clamped to the overhead transmission line. The sensing device acquires real-time information that is used in an iterative process to determine sag, limiting temperature, maximum current load and minimum clearance of the transmission line or conductor.

Abstract: Agents and methods to alter rAAV transduction are provided.

Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.

Abstract: Agents and methods to alter epithelial sodium channel (ENaC) activity.

Abstract: Agents and methods to alter rAAV transduction are provided.

Abstract: An apparatus for retaining bone portions in a desired spatial relationship includes a longitudinal plate extendable along the bone portions. A fastener has a first end portion engageable with a bone portion. A connecting member for connecting the plate to the fastener in any one of an infinite number of positions along the slot includes a recess for receiving a portion of the plate. The recess has an interference fit with the portion of the plate received in the recess. A nut engages the second end portion of the fastener to apply a force to cause the interference fit between the plate and the recess.

Abstract: An apparatus for monitoring and measuring the electrical, thermal and mechanical operating parameters of high voltage power conductors. A toroidal shaped housing, which can be mounted onto an energized conductor, contains all of the necessary electrical instruments to monitor the parameters associated with the conductor. Moreover, the housing includes the processing capability to analyze disturbance and fault events based on these parameters.