Patents by Inventor John Englehardt

John Englehardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090235368
    Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 17, 2009
    Inventors: Michael J. Welsh, Christopher S. Rogers, Randall Prather, John Englehardt, Ziying Yan
  • Publication number: 20040180429
    Abstract: The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosomal mediated trans-splicing in stem cells. The compositions of the invention include stem cells engineered to express pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans-splicing reaction resulting in the generation of novel chimeric RNA molecules (chimeric RNA). In particular, the stem cells of the present invention are genetically engineered to express a PTM that will interact with a specific target pre-mRNA expressed within a stem cell as it differentiates so as to result in correction of a genetic defect responsible for a genetic disorder. The methods of the invention encompass transferring a nucleic acid molecule capable of encoding a PTM of interest into a stem cell followed by transplantation of the PTM modified stem cell into a host.
    Type: Application
    Filed: June 5, 2003
    Publication date: September 16, 2004
    Inventors: Lloyd G. Mitchell, John Englehardt, Xiao Ming Liu