Patents by Inventor John Ernest Shively

John Ernest Shively has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL PENETRATING CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20210330804
    Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.
    Type: Application
    Filed: February 24, 2021
    Publication date: October 28, 2021
    Inventors: Andreas HERRMANN, Hua YU, Piotr Marek SWIDERSKI, John Ernest SHIVELY, Lin LI
  • Cell penetrating conjugates and methods of use thereof
    Patent number: 10967070
    Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: April 6, 2021
    Assignee: CITY OF HOPE
    Inventors: Andreas Herrmann, Hua Yu, Piotr Marek Swiderski, John Ernest Shively, Lin Li
  • BISPECIFIC ANTIGEN-BINDING MOLECULE
    Publication number: 20200181264
    Abstract: Provided herein relates to antigen-binding molecules, in particular bispecific antigen-binding molecules that bind to a cancer cell antigen and an immune cell surface molecule.
    Type: Application
    Filed: August 10, 2018
    Publication date: June 11, 2020
    Inventors: John J. Rossi, Sarah Yoon, Piotr Marek Swiderski, Nagy Habib, John Ernest Shively
  • CELL PENETRATING CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20160317671
    Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.
    Type: Application
    Filed: February 29, 2016
    Publication date: November 3, 2016
    Inventors: Andreas Herrmann, Hua Yu, Piotr Marek Swiderski, John Ernest Shively, Lin Li