Abstract: A device captures, at the time of authentication to a secured session, secondary authentication data of the user that has authenticated using primary authentication credentials. Then, during the session, the system is caused to re-authenticate the user using the secondary authentication credentials (such as original and current user's face images). The system actively monitors the face visible to a camera of the computing device. The system compares the current face to the face image captured at the time of authentication. If the system fails to detect the same face captured initially at the time of authentication, then the system automatedly ends or otherwise locks the session to secure that session from an unauthorized user. Accordingly, the system does not rely merely upon initial authentication for an entire session, but rather reauthenticates the user during a single session in order for the session to be permitted to continue.

Abstract: The invention features compositions and methods for modifying a polynucleotide (e.g., DNA) using a nucleobase editor comprising a first DNA binding protein domain that is catalytically inactive, a domain having base editing activity, and a second DNA binding protein domain having nickase activity. The invention also features a fusion protein comprising a domain having base editing activity (e.g., cytidine deaminase or adenosine deaminase), and two nucleic acid programmable DNA binding protein domains (napDNAbp), a first napDNAbp comprising nickase activity and a second napDNAbp that is catalytically inactive, where at least the two napDNAbps are joined by a linker, as well as related methods for using such base editors, and kits comprising the base editors.

Abstract: Systems and/or methods for determining the natural frequencies of rotating machinery systems, including complex rotating machinery systems such as the powertrains of vehicles powered by internal combustion engines, are disclosed. Embodiments include receiving information from a sensor related to the rotation of a component in the drivetrain (such as a rotating toothed gear), calculating a velocity of the component, calculating a transformed velocity of the component (such as by using a Fast Fourier Transform), selecting one or more shaft orders desired for analysis (such as those based on a predetermined set of likely shaft orders), selecting the amplitudes of the select shaft orders, normalizing the amplitudes, mapping the normalized amplitudes to the Hertz domain, calculating local maxima of the normalized amplitudes, and/or identifying frequencies associated with the calculated local maxima. Additional embodiments include repeating the procedures and identifying clusters of local maxima.

Abstract: A catheter for removal of material from hollow bodies is provided. The catheter may include a catheter body defining an opening and a cutting ribbon extending around the catheter body. The cutting ribbon extends out of the opening of the catheter body and has an expanded configuration having a relatively large hoop size and a retracted configuration having a relatively small hoop size. The cutting ribbon includes an elongated ribbon body, and a blade disposed at a side edge of the ribbon body.

Abstract: The guitar strap locking system includes a primary body having a guitar button receiving channel. A locking mechanism has a bias for being positioned in within the receiving channel for locking a guitar button in place and also capable of being positioned outside of the receiving channel for unlocking a guitar button.

Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.

Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.

Abstract: An assistive device detects deterioration of a person's health, e.g., in an at-home setting, and offers guidance/prompting designed to address or avoid a deteriorated state, based on the person's personalized care plan. A deteriorated state is detected by analysis of multi-faceted data relating to any characteristics usable to assess the person's health, e.g., biometric, activity, or environmental data, as well as data from interactive health assessment screenings delivered via the assistive device. The care plan can contain actions identified by a clinician, e.g., as part of a post-discharge safety plan, or self-identified actions, which may be stabilizing coping mechanism activities. The device may also provide reminders of clinician visits, wellbeing/other activities, medications, and daily affirmations. The device may be configured as a mirror to display the person's image and an avatar with which the person may communicate in a dialog session to provide for a welcoming and engaging experience.

Abstract: A system, method and computer-readable storage medium that add at least one transaction block to a chained sequence of one or more blocks, including receiving a request message having data of an electronic transaction, broadcasting, to nodes in a blockchain network, a consensus request message for generating at least one transaction block including creating a block header that contains a hash pointer to a previous block, and concurrently with updating transaction block data, comparing and performing an action based on the comparing, performing periodic valuation and transmission of an item having a value that is tied to the transaction data, including establishing transmission links with the external entities, determining a value of the item, and establishing movement of the item between the external entities based on the determined value of the item and predetermined thresholds.

Abstract: A “smart” urinary catheterization training device Includes sensors, electronics, etc. to allow clinicians to practice urinary catheterization procedures with instruction and/or feedback for training purposes. The device includes a human anatomy body model that defines a urinary bladder and a proximal urethra model. The device may include an actuator operable to impinge upon the proximal urethra model to provide varied simulation experiences with different levels of difficulty. The device may include a sensor operative to sense catheter presence and provide an output signal that is used to cause delivery of a haptic, audible or other signal to provide positive or negative feedback to the clinician. The device may include a smart glass display positioned to overlie the body model and display at least one of textual, graphical and visual instructions to guide a clinician in performing a catheterization procedure.

Abstract: A catheterization training device includes a rigid housing defining an internal cavity, and a leg/torso body model constructed of lightweight material and storable within the internal cavity. The body model houses a urinary bladder model housed and a proximal urethra model defining a first canal in fluid communication with said urinary bladder model and terminating in a connector. The device further includes at least one genitalia accessory having a configuration of one of human male and human female genitalia. Each genitalia accessory defines a distal urethral model comprising a second canal terminating in a corresponding connector operable to form a mechanical interconnection with the connector of the body model to form a fluid-tight interconnection therewith, and a continuous canal through the distal urethra model and the proximal urethra model and into the urinary bladder model.

Abstract: An antenna may include rigid antenna ribs, a flexible antenna reflector layer, and a flexible support member extending behind the flexible antenna reflector layer between adjacent antenna ribs and having first and second sets of openings therein. A drawstring may extend through the first set of openings between adjacent ribs and a rear support cord is behind the flexible support member between adjacent ribs. Tie cords may extend between the flexible antenna reflector layer and the rear support cord and pass through respective ones of the second set of openings. A biasing member may maintain tension in the drawstring as adjacent antenna ribs move between first and second positions so that the flexible support member defines a pleated support body for the flexible antenna reflector layer.

Abstract: An antenna may include rigid antenna ribs, a flexible antenna reflector layer, and a flexible support member extending behind the flexible antenna reflector layer between adjacent antenna ribs and having first and second sets of openings therein. A drawstring may extend through the first set of openings between adjacent ribs and a rear support cord is behind the flexible support member between adjacent ribs. Tie cords may extend between the flexible antenna reflector layer and the rear support cord and pass through respective ones of the second set of openings. A biasing member may maintain tension in the drawstring as adjacent antenna ribs move between first and second positions so that the flexible support member defines a pleated support body for the flexible antenna reflector layer.

Abstract: The guitar strap locking system includes a primary body having a guitar button receiving channel. A locking mechanism has a bias for being positioned in within the receiving channel for locking a guitar button in place and also capable of being positioned outside of the receiving channel for unlocking a guitar button.

Abstract: A system, method and computer-readable storage medium that add at least one transaction block to a chained sequence of one or more blocks, including receiving a request message having data of an electronic transaction, broadcasting, to nodes in a blockchain network, a consensus request message for generating at least one transaction block including creating a block header that contains a hash pointer to a previous block, and concurrently with updating transaction block data, comparing and performing an action based on the comparing, performing periodic valuation and transmission of an item having a value that is tied to the transaction data, including establishing transmission links with the external entities, determining a value of the item, and establishing movement of the item between the external entities based on the determined value of the item and predetermined thresholds.

Abstract: A method and system for management of multi-party communications that is capable of intelligently assessing a first party/requestor's need and automatedly matching the first party's need to a suitable second party resource that is most probable to meet that need in an efficient manner. The system effectively serves as a chatbot-based (text-based or voice-based) switchboard operator that allows requestors to state a need for a service or consultation, and then automatedly have that need researched and/or matched to the most appropriate resource/service provider based on real-time automated inquiry and/or known data from past research. Further, the system is capable of contacting one or more resources/service providers, confirming that a particular resource/provider can meet the current need, and also coordinating/facilitating a communication session between the first party/requestor and the second party/resource without the need for human intervention.

Abstract: A device captures, at the time of authentication to a secured session, secondary authentication data of the user that has authenticated using primary authentication credentials. Then, during the session, the system is caused to re-authenticate the user using the secondary authentication credentials (such as original and current user's face images). The system actively monitors the face visible to a camera of the computing device. The system compares the current face to the face image captured at the time of authentication. If the system fails to detect the same face captured initially at the time of authentication, then the system automatedly ends or otherwise locks the session to secure that session from an unauthorized user. Accordingly, the system does not rely merely upon initial authentication for an entire session, but rather reauthenticates the user during a single session in order for the session to be permitted to continue.

Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.

Abstract: Provided herein are prime editing systems featuring prime editors complexed with a chimeric prime editing (PE) guide polynucleotide. Systems, prime editor fusion proteins and methods of using such editors for editing a double-stranded DNA target sequence are also provided.

Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.