Abstract: Described herein are atherectomy catheters, systems and methods that include a distal tip region that may be moved laterally so that its long axis is parallel with the long axis of the main catheter body axis. Displacing the distal tip region laterally out of the main catheter body axis exposes an annular blade and opens a passageway for cut tissue to enter a storage region within the catheter. The annular blade may be internally coupled to a drive shaft that rotates the blade, and thus the exposed blade edge may have the same crossing profile (OD) as the rest of the distal end region of the catheter. Also described herein are gear-driven atherectomy devices that may use a cable drive shaft to actuate the annular blade. Both push-to-cut and pull-to-cut variations are described, as are methods for cutting tissue and systems including these atherectomy catheters.

Abstract: Described herein are catheters for use with Optical Coherence Tomography (OCT) that include an optical fiber core having a first refractive index and an interface medium having a second refractive index, where the first and second refractive indexes are mismatched such that receiving electronics configured to receive optical radiation reflected from the reference interface and the target operate in a total noise range that is within 5 dB of the shot noise limit. These OCT catheters may include a silicon die mirror having a reflective coating that is embedded in the interface medium. The optical fiber can be fixed at just the distal end of the catheter, and may be managed within a handle that is attached to the proximal end of the catheter body, and is configured to allow rotation of the both catheter body and the optical fiber relative to the handle.

Abstract: Co-doping the gain medium of a diode-pumped infrared laser to make the laser resistant to long-term degradation from high-intensity internal infrared radiation is disclosed. Co-doping the gain medium with ions such as Cr3+ and Ce3+ that make the gain medium resistant to external ionizing radiation solves problems of long-term degradation of the gain medium.

Abstract: Co-doping the gain medium of a diode-pumped infrared laser to make the laser resistant to long-term degradation from high-intensity internal infrared radiation is disclosed. Co-doping the gain medium with ions such as Cr3+ and Ce3+ that make the gain medium resistant to external ionizing radiation solves problems of long-term degradation of the gain medium.

Abstract: Onset of coagulation of blood in a blood vessel irradiated by electromagnetic radiation is detected by directing light at the blood vessel and monitoring the intensity of a portion of the light remitted from the blood vessel. An increase or decrease in the monitored light intensity indicates the onset of coagulation. The increase or decrease results from the formation of methemoglobin in the blood which accompanies the onset of coagulation. The methemoglobin is formed by photo conversion or thermal conversion of normal blood oxyhemoglobin. The wavelength of the monitoring light is selected to be different from that of the electromagnetic radiation and is preferably a wavelength for which the ratio of its absorptivity in hemoglobin and its absorptivity in normal blood is less than about one-half or greater than about two.

Abstract: An optical system is arranged to deliver electromagnetic radiation in first and second different wavelengths to tissue to be treated therewith. The optical system forms the different-wavelength radiations into beams of different sizes and combines the beams on a common optical path. The different-wavelength radiations on the common optical path are projected by the optical system onto the tissue to be treated to form overlapping treatment spots of different sizes. In one example, the treatment spots are concentric and the size of the treatment spots and the ratio of the treatment-spot sizes can be selectively varied.

Abstract: A slab laser includes a laser-resonator and a plurality of generally-triangular prismatic slabs of a solid-state gain-medium located in the resonator. The prismatic slabs are cooperatively arranged such that laser-light circulating in the laser-resonator follows a convoluted path through the prismatic slabs. Each of the prismatic slabs changes the direction of the convoluted path at least once by about one-hundred-eighty degrees.

Abstract: In an intracavity frequency-converted pulsed laser, output-pulses having a duration longer than three milliseconds are simulated by a burst of temporally spaced-apart pulses having a shorter duration, the burst duration being about equal to the duration of the pulse being simulated. In an example of the laser including a KTP crystal providing frequency-doubling and having an Nd:YAG gain-medium for providing fundamental radiation at a wavelength of 1064 nm, a thin-etalon having a thickness of about 75 micrometers is included in the laser cavity to suppress generation of laser-radiation at wavelengths of 1061 and 1074 nm. Suppression of oscillation at these wavelengths prevents damage in the KTP crystal due to abrupt intracavity power surges thereby preventing damage to the KTP crystal. Examples of intracavity-pumped optical parametric oscillators including a thin etalon and operated in a similar manner are also disclosed.