Patents by Inventor John F. Brognard

John F. Brognard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250032489
    Abstract: Mixed lineage kinase (MLK) inhibitors are disclosed. The compounds inhibit kinase activity. The compounds may be used to treat diseases or conditions characterized at least in part by overexpression of one or more MLKs. The compounds have a structure according to formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 30, 2022
    Publication date: January 30, 2025
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: John F. Brognard, Rolf E. Swenson, Amy L. Funk, Carolyn W. Hitko, Katherine M. Nyswaner, Knickole L. Bergman, Venkatareddy Sabbasani, Eric Lindberg, Steven D. Cappell, Meghri Katerji
  • Publication number: 20240190838
    Abstract: Leucine zipper-bearing kinase (LZK) targeted degraders are disclosed. The compounds have a general formula Q-L-Z where Q is an LZK binding moiety, L is a linker, and Z is an E3-ligase binding moiety. The compounds inhibit LZK activity and/or degrade LZK. The compounds may be used to treat diseases or conditions characterized at least in part by LZK overexpression.
    Type: Application
    Filed: March 1, 2023
    Publication date: June 13, 2024
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: John F. Brognard, Rolf E. Swenson, Amy L. Funk, Carolyn W. Hitko, Katherine M. Nyswaner, Eric Lindberg, Venkatareddy Sabbasani, Knickole L. Bergman