Abstract: A tangential flow filtration manifold takes a modular form for interconnection in a manifolded arrangement for aggregating a total filtration area of the aggregate filter (membrane) surface. A plurality of modular TFF cassette filters may be or stacked on the TFF manifold such that it allows the number of interconnected filters, as well as the membrane surface area within each cassette, to be readily reconfigured. A single output, or filtrate connection on the TFF manifold simplifies fluidic plumbing connections for directing and gathering the filtrate (permeate) produced as output.

Abstract: Cassettes for tangential flow filtration (TFF) are disclosed which reduce assembly and disassembly required for aseptic filtration. Packaging systems and methods for the TFF cassettes are also disclosed.

Abstract: A filtration cassette is described. The filtration cassette can include one or more filtrate channel spacers and one or more feed channel spacers. Each of the feed channel spacers and each of the filtrate channel spacers define an open interior volume bounded by an inner perimeter and include at least one feed port and at least one filtrate port. The filtrate channel spacers and the feed channel spacers are arranged such that the feed ports and the filtrate ports are positioned in respective alignment. The filtration cassette further includes one or more membranes disposed between the filtrate channel spacers and the feed channel spacers, and one or more retaining members at either end of the filtration cassette. A thin film of adhesive binds together the filtrate channel spacers, the feed channel spacers, and the membranes.

Abstract: The invention relates to a dialysis apparatus, comprising: a body with two planar sides, wells contained in the body, the wells being accessible from one planar side, a plurality of membranes for separating the wells into compartments, wherein each of said membranes is isolated one from another.

Abstract: Filtration devices that include filtration cassettes that feature a plurality of stacked subassemblies, wherein at least one of the subassemblies includes a porous membrane having a front side and a back side and a perimeter; and an overmolded frame that encapsulates the membrane around the perimeter of the front side and the back side of the membrane; wherein the overmolded frame forms at least one retentate port, at least one feed port, at least one filtrate port, and a flow channel proximate a perimeter of the frame; and an overmolded plastic jacket that penetrates the flow channels of the subassemblies to seal the stacked subassemblies; and methods for making the filtration device and cassettes.

Abstract: The invention relates to a dialysis apparatus, comprising: a body with two planar sides, wells contained in the body, the wells being accessible from one planar side, a plurality of membranes for separating the wells into compartments, wherein each of said membranes is isolated one from another.

Abstract: This invention relates to a method and apparatus for surface hardening metals by means of a concentrated beam of electrons. The electron beam is directed and focused to a desired spot on the surface of the said workpiece and is caused to move incrementally from one to the next of a predetermined pattern of points on the work surface. The beam is directed to each point in turn for a predetermined length of time and moved from point to point at a relatively rapid rate. The pattern is projected over the desired surface of the work a predetermined number of times so that the material to be heat treated is brought above the transformation temperature and maintained below the melting temperature by close control of the electron beam parameters. A programmable computer retains in its memory a number of predetermined displacement patterns for the electron beam and controls all the electron beam gun parameters and all machine functions.