Patents by Inventor John F. DiPersio

John F. DiPersio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel In Vitro and In Vivo Enrichment Strategy Targeting Lymphocytes Derived from Vector Transduced HSCS for Therapy of Disorders
    Publication number: 20230332112
    Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.
    Type: Application
    Filed: March 7, 2023
    Publication date: October 19, 2023
    Inventors: Jeffrey A. Medin, John F. Dipersio, Murtaza S. Nagree
  • Methods and compositions for treatment of cancer
    Patent number: 11696926
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for upregulating MHC class II in cancer cells (e.g., a hematological cancer cell). Also provided are methods of treatment for subjects suffering from hematological cancers, comprising administration of interferon-? (IFN-?). The methods of treatment provided herein may be particularly suitable for subjects who have received an allogenic transplant or have suffered a relapse.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: July 11, 2023
    Assignee: Washington University
    Inventors: Matthew Christopher, John F. DiPersio, Timothy J. Ley, Allegra Petti, Michael P. Rettig
  • METHOD OF TREATING A SOLID TUMOR WITH A COMBINATION OF AN IL-7 PROTEIN AND CAR-BEARING IMMUNE CELLS
    Publication number: 20230210952
    Abstract: The present disclosure relates to methods of treating a solid tumor with an IL-7 protein in combination with a population of modified immune cells, e.g, CAR-bearing immune cells (e.g., CAR-T cells or iNKT-CAR cells) and/or transgenic TCR-bearing immune cells.
    Type: Application
    Filed: February 4, 2021
    Publication date: July 6, 2023
    Applicants: Washington University, NeoImmuneTech, Inc.
    Inventors: John F. DIPERSIO, Matthew COOPER, Se Hwan YANG, Byung Ha LEE, Donghoon CHOI
  • and enrichment strategy targeting lymphocytes derived from vector transduced HSCs for therapy of disorders
    Patent number: 11597917
    Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: March 7, 2023
    Assignees: The Medical College of Wisconsin, Inc., University Health Network, Washington University in St. Louis
    Inventors: Jeffrey A. Medin, John F. Dipersio, Murtaza S. Nagree
  • USE OF INTERLEUKIN-7 AND CHIMERIC ANTIGEN RECEPTOR (CAR)-BEARING IMMUNE EFFECTOR CELLS FOR TREATING TUMOR
    Publication number: 20210299223
    Abstract: Disclosed herein are therapeutic uses for treating cancer in a subject in need thereof, comprising administering to the subject a population of chimeric antigen receptor (CAR)-bearing immune effector cells and an IL-7 protein (e.g., modified IL-7 protein).
    Type: Application
    Filed: July 30, 2019
    Publication date: September 30, 2021
    Applicants: WASHINGTON UNIVERSITY, NEOIMMUNETECH, INC.
    Inventors: John F. DIPERSIO, Matthew COOPER, Karl STASER, Jaehan PARK, Byung Ha LEE, Dong Hoon CHOI
  • METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER
    Publication number: 20200237817
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for upregulating MHC class II in cancer cells (e.g., a hematological cancer cell). Also provided are methods of treatment for subjects suffering from hematological cancers, comprising administration of interferon-? (IFN-?). The methods of treatment provided herein may be particularly suitable for subjects who have received an allogenic transplant or have suffered a relapse.
    Type: Application
    Filed: January 28, 2020
    Publication date: July 30, 2020
    Applicant: Washington University
    Inventors: Matthew Christopher, John F. DiPersio, Timothy J. Ley, Allegra Petti, Michael P. Rettig
  • NOVEL IN VITRO AND IN VIVO ENRICHMENT STRATEGY TARGETING LYMPHOCYTES DERIVED FROM VECTOR TRANSDUCED HSCS FOR THERAPY OF DISORDERS
    Publication number: 20200181582
    Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.
    Type: Application
    Filed: June 6, 2018
    Publication date: June 11, 2020
    Inventors: Jeffrey A. Medin, John F. Dipersio, Murtaza S. Nagree
  • GENE EDITING OF CAR-T CELLS FOR THE TREATMENT OF T CELL MALIGNANCIES WITH CHIMERIC ANTIGEN RECEPTORS
    Publication number: 20200000937
    Abstract: The present disclosure provides the use of fratricide-resistant chimeric antigen receptor T (CAR-T) cells targeting antigens expressed by T cell malignancies.
    Type: Application
    Filed: August 3, 2017
    Publication date: January 2, 2020
    Applicant: Washington University
    Inventors: John F. DiPersio, Matthew Cooper