Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A method and system for allocating and freeing storage are provided. The method can be built on top of any existing storage management algorithm. The method is described as being built upon the heap storage algorithm most often associated with the C programming environment. The method operates by breaking all storage requests into a fixed number of pools. Each pool is then managed by three tiers of management. The first tier is a so-called quick pool consisting of storage blocks which have already been used and freed and are managed on a LIFO queue. The second tier is made up of cell pool extents that are carved from the heap and then further subdivided into blocks of the appropriate size for each pool. The third tier is made up of the existing heap management algorithms or any other storage management algorithm. The method relies on atomic hardware instructions for removing blocks from the quick pools and cell extents.

Abstract: A method for indicating the presence of methaqualone and/or mecloqualone is disclosed comprising the steps of adding seven drops of 85% solution of formic acid to the substance suspected of containing methaqualone or mecloqualone. Thereafter, adding five drops of five percent aqueous solution of sodium nitrite, and six to ten drops of chloroform. A positive indication of the presence of methaqualone or mecloqualone results in a yellow color in the chloroform and a clear water-white color in the aqueous solution.

Abstract: A method is provided for manufacturing tungsten carbide insert-type cutter cones for a rock bit for drilling oil wells and the like. A cone blank is formed from medium to high carbon steel by forging and machining. The cone blank has a generally conical external surface, a generally cylindrical internal bearing cavity, and a circumferentially extending ball bearing race in the bearing cavity. The cone blank is heat treated by quenching and tempering to a desired core hardness. Insert holes are drilled in the external surface of the heat treated cone blank for insertion of tungsten carbide inserts. The surface of the ball race is selectively hardened by heating and quenching for forming a surface layer having a higher hardness than the core hardness. Selective hardening of the ball race is obtained by applying energy to the surface of the ball race by induction heating, an electron beam or a laser beam to austenitize a surface layer which is rapidly cooled for hardening.

Abstract: Segments of a rock bit are secured together by electron-beam welding. The segments are slightly spaced apart prior to welding by a thin shim of alloying metal such as titanium which improves ductility of the weld and is a strong carbide-former during welding. The shim is positioned between adjacent segments in the region of the crown or dome of the bit. The resulting welded interface is a fine-grain stress-relieved structure with good ductility and resistance to cracking.

Abstract: Segments of a rock bit are secured together by electron-beam welding. The segments are slightly spaced apart prior to welding by a thin shim of alloying metal such as titanium which improves ductility of the weld and is a strong carbide-former during welding. The shim is positioned between adjacent segments in the region of the crown or dome of the bit. The resulting welded interface is a fine-grain stress-relieved structure with good ductility and resistance to cracking.