Patents by Inventor John F. Kadow

John F. Kadow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC PYRROLIDINE DERIVATIVES
    Publication number: 20090186933
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Application
    Filed: April 2, 2009
    Publication date: July 23, 2009
    Inventors: JOHN F. KADOW, Qiufen May Xue, Tao Wang, Zhongxing Zhang, Nicholas A. Meanwell
  • Compounds for the treatment of Hepatitis C
    Patent number: 7547690
    Abstract: The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: June 16, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Compounds for the treatment of hepatitis C
    Patent number: 7541352
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: June 2, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kap-Sun Yeung, John F. Kadow, Katharine A. Grant-Young
  • Compounds for the treatment of hepatitis C
    Patent number: 7541353
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: June 2, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Compounds for the treatment of Hepatitis C
    Patent number: 7538102
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: May 26, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kap-Sun Yeung, John A. Bender, Robert G. Gentles, Zhong Yang, Min Ding, Yong Tu, Piyasena Hewawasam, Ying Han, John F. Kadow
  • Indole, azaindole and related heterocyclic pyrrolidine derivatives
    Patent number: 7531552
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: May 12, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: John F. Kadow, Qiufen May Xue, Tao Wang, Zhongxing Zhang, Nicholas A. Meanwell
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7521441
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: April 21, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Piyasena Hewawasam, Min Ding, Carl P. Bergstrom, Scott W. Martin, Kap-Sun Yeung, Thomas W. Hudyma, Xiaofan Zheng, John A. Bender, John F. Kadow
  • Compounds for the treatment of hepatitis C
    Patent number: 7517872
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: April 14, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Andrew Nickel, John F. Kadow
  • Piperazine enamines as antiviral agents
    Patent number: 7504399
    Abstract: This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and azaindole piperazine enamine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to a compound of Formula I useful for the treatment of HIV and AIDS.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: March 17, 2009
    Assignee: Bristol-Meyers Squibb Company
    Inventors: Tao Wang, John F. Kadow, Zhongxing Zhang, Zhiwei Yin, Nicholas A. Meanwell
  • Composition and antiviral of substituted azaindoleoxoacetic piperazine derivatives
    Patent number: 7501420
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: March 10, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, Zhongxing Zhang, Nicholas A. Meanwell, John F. Kadow, Zhiwei Yin, Qiufen May Xue, Alicia Regueiro-Ren, John D. Matiskella, Yasutsugu Ueda
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7485633
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: February 3, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nicholas A. Meanwell, Robert G. Gentles, Min Ding, John A. Bender, John F. Kadow, Piyasena Hewawasam, Thomas W. Hudyma, Xiaofan Zheng
  • Indolobenzazepine HCV NS5B inhibitors
    Patent number: 7473688
    Abstract: The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: January 6, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Carl P. Bergstrom, John A. Bender, Robert G. Gentles, Piyasena Hewawasam, Thomas W. Hudyma, John F. Kadow, Scott W. Martin, Alicia Regueiro-Ren, Kap-Sun Yeung, Yong Tu, Katharine A. Grant-Young, Xiaofan Zheng
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7452876
    Abstract: The invention encompasses compounds as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: November 18, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kap-Sun Yeung, Katharine A. Grant-Young, Min Ding, Robert G. Gentles, John F. Kadow
  • Tetrahydrocarboline antiviral agents
    Patent number: 7449476
    Abstract: The invention encompasses a series of tetrahydrocarboline compounds of Formula I which inhibit HIV entry by attaching to the exterior viral envelop protein gp120 and interrupting the viral entry process, possibly by interfering with the cellular receptor CD4. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: November 11, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Edward H. Ruediger, Daniel H. Deon, John F. Kadow
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080226591
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 18, 2008
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080226592
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 18, 2008
    Inventors: Kap-Sun Yeung, John A. Bender, Robert G. Gentles, Zhong Yang, Min Ding, Yong Tu, Piyasena Hewawasam, Ying Han, John F. Kadow
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080227769
    Abstract: The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: February 28, 2008
    Publication date: September 18, 2008
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • HCV NS5B Inhibitors
    Publication number: 20080221090
    Abstract: The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: March 3, 2008
    Publication date: September 11, 2008
    Inventors: Kap-Sun Yeung, John F. Kadow
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080206191
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 28, 2008
    Inventors: Andrew Nickel, John F. Kadow
  • INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC 4-ALKENYL PIPERIDINE AMIDES
    Publication number: 20080188481
    Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS.
    Type: Application
    Filed: January 17, 2008
    Publication date: August 7, 2008
    Inventors: Tao Wang, John F. Kadow, Nicholas A. Meanwell, Kap-Sun Yeung, Zhongxing Zhang, Zhiwei Yin, Zhilei Qiu, Daniel H. Deon, Clint A. James, Edward H. Ruediger, Carol Bachand