Abstract: A bubble trap assembly for critical bioprocess applications. The assembly includes a disposable liner including a gas port disposed on a top of the liner, and two fluid ports disposed on the bottom of the liner. The fluid ports coupled in-line to the critical bioprocess application. A rigid vessel is included for housing the liner. The liner being sized to substantially conform to a shape of the inside of the vessel. The vessel includes an upper aperture for aligning with the gas port and a bottom opening opposed to the upper aperture. A bottom cap is included, removeably secured to the vessel and closing the bottom opening. The bottom cap together with the vessel substantially enclosing the liner. The bottom cap includes two lower apertures for aligning with the fluid ports. The bottom cap being formed by two cap portions capable of being separated.

Abstract: A bubble trap assembly for critical bioprocess applications. The assembly includes a disposable liner for placing in a fluid stream of a critical bioprocess application. The liner includes at least one gas port disposed on a top of the liner, and at least two fluid ports disposed substantially on the bottom of the liner. The fluid ports are adapted to be coupled in-line to the critical bioprocess application. A rigid vessel is included for housing the liner. The liner being sized to substantially conform to a shape of the inside of the vessel. The vessel includes at least one upper aperture for aligning with the at least one gas port and a bottom opening opposed to the at least one upper aperture. A bottom cap is included, removeably secured to the vessel and closing the bottom opening. The bottom cap together with the vessel substantially enclosing the liner. The bottom cap includes at least one lower aperture for aligning with the fluid ports.

Abstract: An ampoule filling and sealing machine with feeding, filling, sealing and loading stations. A horizontally oriented endless chain drive moves the ampoules through the filling and sealing stations. Belts or a reciprocating agitator are provided in the feeding station. A plurality of spring-loaded movable rails and a final stationary rail guide the line of ampoules in the filling station. The filled ampoules in the sealing station are spun by rotating pinions of cylindrical rollers on the endless chain drive in cooperation with inclined discs. In the loading station a channel receives a line of sealed ampoules. One side of the middle portion of the channel is a horizontal flat spring backed up by a spring-loaded bar. A fixed stop is spaced from the backing bar. A spring-loaded gate is at the inlet to each loading tray.