Abstract: Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.

Abstract: Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.

Abstract: Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.

Abstract: Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop polypectomy system including a means for securely closing the loop. In some embodiments, the open loop polypectomy system comprises a snare wire and a capture mechanism wherein, when the snare wire is advanced, the snare wire extends from a distal portion of the open loop polypectomy system along a path passing through the capture mechanism. After the snare wire has advanced through the plane of the capture mechanism, retraction of the capture mechanism secures the snare wire, creating a formed loop around a target tissue. Retraction of at least one of the snare wire and capture mechanism contracts the formed loop, resecting the target tissue.

Abstract: Neurostimulator devices and methods of using these devices are described. The neurostimulator devices can include a stimulation assembly connectable to a plurality of electrodes; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern.

Abstract: Described are devices including stimulation assemblies connectable to a plurality of electrodes. The plurality of electrodes can be configured to connect to a spinal cord at a location below a lesion of the spinal cord. The stimulation assembly can be configured to deliver stimulation to selected ones of the plurality of electrodes when the stimulation assembly is connected to the plurality of electrodes when located below the lesion of the spinal cord. Methods of using the devices are also described.

Abstract: A neurostimulator devices and systems for use with groups of electrodes placed within a subject's body. The devices and systems can include training devices and/or pulse generation systems.

Abstract: Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop snare device including a means for securely closing the loop. In some embodiments, a snare device comprises a snare wire and a capture mechanism wherein, when the snare wire is advanced, the snare wire extends from a distal portion of the device along an arcuate path curving back toward the capture mechanism such that, after the snare wire is advanced, activation of the capture mechanism captures the snare wire, creating a formed loop around a target tissue. Retraction of at least one of the snare wire and capture mechanism contracts the formed loop, resecting the target tissue.

Abstract: A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator.

Abstract: An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality of electrodes is configured to induce an electric field across each of the plurality of separation channels sufficient to cause analytes in the samples to migrate along each of the channels. The system further comprises a plurality of detectors configured to detect the analytes.

Abstract: An embodiment of the invention is directed to a capillary electrophoresis apparatus comprising a plurality of separation micro-channels. A sample loading channel communicates with each of the plurality of separation channels. A driver circuit comprising a plurality of electrodes is configured to induce an electric field across each of the plurality of separation channels sufficient to cause analytes in the samples to migrate along each of the channels. The system further comprises a plurality of detectors configured to detect the analytes.

Abstract: A method, system, and computer-readable medium are provided which monitor a condition of an eye. The system includes a communication interface and a processor operably coupled to the communication interface. The communication interface is configured to receive an intraocular pressure measurement datum and a time datum associated with the time the intraocular pressure measurement was measured using an eye measurement system. The processor is configured to receive the intraocular pressure measurement datum and the time datum, to receive a dispensed amount datum associated with an amount of a drug administered to an eye of a user and a second time datum associated with the time the drug was administered, and to store the received intraocular pressure measurement datum, the received time datum, the received dispensed amount datum, and the received second time datum to monitor a condition of the eye.

Abstract: The present invention provides a system 10 for measuring and remotely monitoring strain in an element 1 having a strain sensor 20, a telemetry circuit 40 for transmitting strain data to a remote location, and a reader module 60 for transmitting energy to the telemetry circuit and receiving said data.

Abstract: The present invention is a capillary electrophoresis device, comprising a substrate; a first channel in the substrate, and having a buffer arm and a detection arm; a second channel in the substrate intersecting the first channel, and having a sample arm and a waste arm; a buffer reservoir in fluid communication with the buffer arm; a waste reservoir in fluid communication with the waste arm; a sample reservoir in fluid communication with the sample arm; and a detection reservoir in fluid communication with the detection arm. The detection arm and the buffer arm are of substantially equal length.

Abstract: The present invention is a system and method of precisely locating a football on a football field in order to determine whether a first down has been achieved. The invention employs an optical distance measuring device that communicates via a wireless transceiver with a portable display device controlled by an on-field official. The portable display device is equipped with an operator interface used to request measurements of the ball location and is suitably programmed to calculate whether a first down has been achieved based on first and second ball location data points.

Abstract: The present invention provides a system 10 for measuring and remotely monitoring strain in an element 1 having a strain sensor 20, a telemetry circuit 40 for transmitting strain data to a remote location, and a reader module 60 for transmitting energy to the telemetry circuit and receiving said data.

Abstract: The present invention is a capillary electrophoresis device, comprising a substrate; a first channel in the substrate, and having a buffer arm and a detection arm; a second channel in the substrate intersecting the first channel, and having a sample arm and a waste arm; a buffer reservoir in fluid communication with the buffer arm; a waste reservoir in fluid communication with the waste arm; a sample reservoir in fluid communication with the sample arm; and a detection reservoir in fluid communication with the detection arm. The detection arm and the buffer arm are of substantially equal length.

Abstract: The present invention is a system and method of precisely locating a football on a football field in order to determine whether a first down has been achieved. The invention employs an optical distance measuring device that communicates via a wireless transceiver with a portable display device controlled by an on-field official. The portable display device is equipped with an operator interface used to request measurements of the ball location and is suitably programmed to calculate whether a first down has been achieved based on first and second ball location data points.

Abstract: Voltage translator apparatus to translate TTL or CMOS logic level inputs to 0/-5 V logic levels that is insensitive to temperative and bias supply variation. A unique circuit structure comprises a level shift stage employing transistors configured to level shift a source of operating potential to a controlling potential to be applied to a predriver stage. The controlling potential is a function of the input logic levels. The predriver stage drives an output stage capable of providing complementary 0/-5 V logic outputs. The configuration is such as to afford low power consumption as well as proper operation over wide bias supply and temperature ranges.

Abstract: A temperature compensation circuit enables the reliable operation of semiconductor logic gates over wide temperature ranges. The temperature compensation circuit includes a thin film resistor in series with an implanted resistor, both located on the same semiconductor substrate and both having one terminal connected together. The other terminal of one of the resistors is coupled to a point of reference potential, while the other terminal of the other resistor is coupled to an operating potential. A voltage is provided at the junction between the two resistors, which voltage is coupled to the logic gates. The voltage serves as a pull-down source and tracks over the wide temperature range to enable the logic gate to reliably operate with an adequate noise margin over temperature ranges between -55.degree. C. to +125.degree. C.