Patents by Inventor John F. Poletto

John F. Poletto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted quinolinecarboxylic acids
    Patent number: 4968702
    Abstract: Substituted quinolinecarboxylic acids useful in the treatment of arthritis by inhibiting the progressive joint deterioration characteristic of arthritic disease and for inducing immunosuppression are disclosed. Methods of synthesis and use of the novel compounds are also disclosed.
    Type: Grant
    Filed: January 17, 1989
    Date of Patent: November 6, 1990
    Assignee: American Cyanamid Company
    Inventors: John F. Poletto, Dennis W. Powell, Diane H. Boschelli
  • 2-Phenyl-4-quinoline carboxylic acids
    Patent number: 4847381
    Abstract: Substituted 4-quinoline-carboxylic acids useful in the treatment of arthritis and inhibition of progressive joint deterioration are disclosed together with methods of use and synthesis thereof.
    Type: Grant
    Filed: August 31, 1987
    Date of Patent: July 11, 1989
    Assignee: American Cyanamid Company
    Inventors: Leslie H. Sutherland, Adolph E. Sloboda, Ralph G. Child, John F. Poletto, Dennis W. Powell
  • Oxalylamides useful as dental antiplaque agents and inhibitors of connective tissue destruction
    Patent number: 4599204
    Abstract: This invention concerns novel compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals and as inhibitors of connective tissue destruction. The compounds of this invention comprise certain [oxalylbis(iminophenylenecarbonylimino)]bis[hydroxynaphthalenesulfonic acids] and salts thereof which may be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional pharmaceutical compositions.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: July 8, 1986
    Assignee: American Cyanamid Company
    Inventors: John F. Poletto, Seymour Bernstein
  • Novel hydroxy substituted prostanoic acids, esters, congeners, intermediates and process
    Patent number: 4439365
    Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.
    Type: Grant
    Filed: July 18, 1979
    Date of Patent: March 27, 1984
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, John F. Poletto, Robert E. Schaub, Karel F. Bernady
  • Ureylenebis substituted (or unsubstituted) phenylene-carbonyl (or sulfonyl)-imino-1,3,5 or 6-naphthalene-trisulfonic acids and salts
    Patent number: 4387059
    Abstract: Ureylenebis substituted (or unsubstituted) phenylenecarbonyl (or sulfonyl)-imino-1,3,5 or 6-naphthalenetrisulfonic acids and salts thereof, useful as complement inhibitors, the intermediates thereof, and the process of making such intermediates and end products.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: June 7, 1983
    Assignee: American Cyanamid Company
    Inventors: Ransom B. Conrow, John F. Poletto, Seymour Bernstein
  • Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
    Patent number: 4343949
    Abstract: This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
    Type: Grant
    Filed: October 12, 1979
    Date of Patent: August 10, 1982
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • Carboxyalkyl derivatives of rutin poly(H-)sulfate
    Patent number: 4342753
    Abstract: Carboxyalkyl derivatives of rutin polyl(H-)sulfate and salts thereof useful as complement inhibitors.
    Type: Grant
    Filed: June 15, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Vijay G. Nair, John F. Poletto, Seymour Bernstein
  • Carbalkoxymethyl derivatives of rutin poly(H-)sulfate and method of use
    Patent number: 4342752
    Abstract: Carbalkoxymethyl derivatives of rutin poly(H-)sulfate and salts thereof useful as complement inhibitors.
    Type: Grant
    Filed: June 15, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Vijay G. Nair, John F. Poletto, Seymour Bernstein
  • Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
    Patent number: 4293704
    Abstract: This invention relates to novel 4-oxy-2-substituted-cyclopent-2-en-1-ones of the following general formula: ##STR1## and the optical antipodes, racemic mixtures, and diastereomeric mixtures thereof wherein p is an integer from 2 to 6, inclusive, and J is hydrogen or an appropriate and compatible blocking group such as tetrahydropyranyl or tri(lower alkyl)silyl. Suitable lower alkyl groups contemplated by the present invention are those having up to four carbon atoms such as methyl, ethyl, isopropyl, tert-butyl, etc.
    Type: Grant
    Filed: January 28, 1980
    Date of Patent: October 6, 1981
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • Halogenated-naphthalenetriyltris(sulfonylimino)-aryl multicarboxylic acids and salts thereof
    Patent number: 4282375
    Abstract: Halogenated-naphthalenetriyltris(sulfonylimino)-aryl multicarboxylic acids and salts thereof useful as complement inhibitors.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: August 4, 1981
    Assignee: American Cyanamid Company
    Inventors: Seymour Bernstein, John F. Poletto
  • Halogenated-naphthalenetriyltris(sulfonylimino)-aryl disulfonic acids and salts thereof
    Patent number: 4265829
    Abstract: Halogenated-naphthalenetriyltris(sulfonylimino)-aryl disulfonic acid and salts thereof useful as complement inhibitors.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: May 5, 1981
    Assignee: American Cyanamid Company
    Inventors: Seymour Bernstein, John F. Poletto
  • Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
    Patent number: 4237316
    Abstract: This disclosure describes novel 4-oxy-2-substituted-cyclopent-2-en-1-ones useful as intermediates for the preparation of homo and nor prostaglandins of the E.sub.2, E.sub.3 and F series.
    Type: Grant
    Filed: September 25, 1975
    Date of Patent: December 2, 1980
    Assignee: American Cyanamid Company
    Inventors: Karel F. Bernady, Middleton B. Floyd, Jr., John F. Poletto, Robert E. Schaub, Martin J. Weiss
  • Ureylene phenylene anionic naphthalenesulfonic acids
    Patent number: 4231958
    Abstract: Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl (and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: November 4, 1980
    Assignee: American Cyanamid Company
    Inventors: Gerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
  • Ureylene phenylene anionic naphthalenesulfonic acids
    Patent number: 4229372
    Abstract: Novel ureylenebis-[substituted-phenylenecarbonylimino-substituted-phenylenesulfo nylimino]naphthalenetrisulfonic acid alkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl imino, substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, alkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: October 21, 1980
    Assignee: American Cyanamid Company
    Inventors: Gerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
  • Ureylene phenylene anionic naphthalenesulfonic acids
    Patent number: 4229370
    Abstract: Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-subsituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-na phthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: October 21, 1980
    Assignee: American Cyanamid Company
    Inventors: Gerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
  • Ureylene naphthalene sulfonic acids
    Patent number: 4218395
    Abstract: Ureylenebis-symmetrical-phenenylbiscarbonylimino-substituted phenylenecarbonylimino-tetranaphthalenepolysulfonic acid benzoic acid salts, and nitro- and amino-substituted phenylenebiscarbonylimino-substituted benzamido-phenylenedicarbonyl-dinaphthalenepolysulfonic acid benzoic acid salts which are intermediates for the preparation of the active ureides which have complement inhibiting activity.
    Type: Grant
    Filed: August 28, 1978
    Date of Patent: August 19, 1980
    Assignee: American Cyanamid Company
    Inventors: John F. Poletto, Seymour Bernstein
  • Ureylene phenylene anionic naphthalenesulfonic acids
    Patent number: 4185033
    Abstract: Novel ureylenebis-[substituted-phenylenecarbonylimino-substituted-phenylenecarbo nylimino-naphthalenetrisulfonic acid, alkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonylimino, substituted-phenylenecarbonylimino-naphthalenetrisulfonic acid, alkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
    Type: Grant
    Filed: July 11, 1978
    Date of Patent: January 22, 1980
    Assignee: American Cyanamid Company
    Inventors: Gerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
  • Ureylene phenylene anionic naphthalenesulfonic acids
    Patent number: 4185032
    Abstract: Novel ureylenebis-[substituted-phenylenecarbonylimino-substituted-phenylenecarbo nylimino-naphthalenetrisulfonic acid, alkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonylimino, substituted-phenylenecarbonylimino-naphthalenetrisulfonic acid, alkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
    Type: Grant
    Filed: July 11, 1978
    Date of Patent: January 22, 1980
    Assignee: American Cyanamid Company
    Inventors: Gerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
  • Ureylene phenylene anionic naphthalenesulfonic acids as complement inhibitors
    Patent number: 4180587
    Abstract: A method of inhibiting the complement system in a warm-blooded animal which comprises the administration of a ureylenebis-[substituted-phenylenecarbonyl (and sulfonyl) imino-substituted-phenylene carbonylimino-naphthalenetrisulfonic acid, hexaalkali metal salt].
    Type: Grant
    Filed: July 11, 1978
    Date of Patent: December 25, 1979
    Assignee: American Cyanamid Company
    Inventors: Gerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
  • Dental antiplaque agents and inhibitors of connective tissue destruction
    Patent number: H83
    Abstract: This invention concerns novel compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals and as inhibitors of connective tissue destruction. The compounds of this invention comprise certain [ureylenebis-(phenylenesulfonylimino)]bis[hydroxynaphthalenesulfonic acids] and salts thereof which may be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional pharmaceutical compositions.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: July 1, 1986
    Assignee: American Cyanamid Company
    Inventors: John F. Poletto, Seymour Bernstein