Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: A bone positioning guide may include a main body member, a shaft, and a bone engagement member. The shaft can be movably connected to the main body member and have the bone engagement member rotatably coupled to its distal end. The bone engagement member can have a surface configured to engage a bone. The main body member can also include a tip opposite the bone engagement member for engaging a second bone. In use, the bone engagement member may be positioned in contact with a medial side of a first metatarsal while the tip is positioned in contact with a lateral side of a different metatarsal, such as a second metatarsal. The shaft can then be moved to advance the bone engagement member toward the tip, causing realignment of the first metatarsal.

Abstract: Wavelength-selective films are visibly apparent under the selective wavelength. Wavelength-selective films typically reflect off axis the selected wavelength and therefore can provide high-contrast against a background when applied in a pattern on a substrate. However, it is difficult to apply unique patterned embedded images from film. Disclosed is a cost-effective method and construction of a patterned wavelength-selective image to a substrate. In the disclosed wavelength-selective image, wavelength-selective film particles are applied to an adhesive pattern to create the wavelength-selective image.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An improvement to a standardized design of a body for small-bore connectors for liquids and/or gases in a healthcare application, wherein the body has a spout with a standardized upper portion. The upper portion can have a standardized external thread or can have a different size and shape for the external thread. The body can have a standardized internal flange or another differently sized and shaped internal flange. The body can have an internal void though which the liquids and/or gases flow. At least a portion of the standardized internal flange or another internal flange can be eliminated or removed to reduce a flow restriction caused by the standardized internal flange and thus increase a flow area of the internal void.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: Embodiments that relate to systems and methods for navigating a user interface via a keyboard are provided. In one embodiment, one or more keystroke events corresponding to one or more keystrokes are received from a listener module. The one or more keystrokes are associated with one or more keys that correspond to a navigation direction in the user interface. A current HTML element in the user interface is identified that has a keyboard focus and may receive input from a keyboard navigation module. A destination HTML element that is nearest to the current HTML element in the navigation direction and can receive keyboard focus is located in the user interface. The keyboard focus is then moved to the destination HTML element.

Abstract: A Pb-free solder includes a ternary eutectic composition consisting essentially of about 93.6 weight % Sn-about 4.7 weight % Ag-about 1.7 weight % Cu having a eutectic melting temperature of about 217.degree. C. and variants of the ternary composition wherein the relative concentrations of Sn, Ag, and Cu deviate from the ternary eutectic composition to provide a controlled melting temperature range (liquid-solid "mushy" zone) relative to the eutectic melting temperature (e.g. up to 15.degree. C. above the eutectic melting temperature).

Abstract: This disclosure relates to a device which enables adjustments and positioning in three dimensions for racks and other bulk stowage structures. A friction surface provides a sliding adjustment for stowage structures having surfaces in contact therewith. Further, a pin connected to a spacer is slidably inserted into a button base to enable vertical adjustments for raising and lowering the stowage structure, as needed, by adding or removing shims thereon.

Abstract: A method for measuring texture of metal plates or sheets using non-destructive ultrasonic investigation includes measuring the velocity of ultrasonic energy waves in lower order plate modes in one or more directions, and measuring phase velocity dispersion of higher order modes of the plate or sheet if needed. Texture or preferred grain orientation can be derived from these measurements with improves reliability and accuracy. The method can be utilized in production on moving metal plate or sheet.

Abstract: A method for measuring texture of metal plates or sheets using non-destructive ultrasonic investigation includes measuring the velocity of ultrasonic energy waves in lower order plate modes in one or more directions, and measuring phase velocity dispersion of higher order modes of the plate or sheet if needed. Texture or preferred grain orientation can be derived from these measurements with improved reliability and accuracy. The method can be utilized in production on moving metal plate or sheet.

Abstract: A hand held navigational-communications transceiver is compressed into a case having a volume of about 37 cubic inches by defining functional implementation for VOR (VHF omni-directional range) navigation. The transceiver can be selectively switched to process and display directional radial information. A microprocessor circuit provides primary circuitry information in combination with transceiver function software held in ROM (read only memory). A plurality of pre-programmed frequencies may be selected.

Abstract: The cartridge disclosed is provided with an extractor means which is instrumental in the removal of the cartridge from the machine, by providing a smooth camming action to move the cartridge away from the machine circuit board. The extractor allows the cartridge to protrude only a small amount outside the machine housing and still be removed such that the cartridge is not rocked or moved to and fro relative to the machine circuit board.

Abstract: An improved method for manufacturing a dentifrice containing dispersed speckles therein includes converting a gel or paste dental composition into a plurality of flowing ribbons thereof, directing a stream of speckles onto one such ribbon of dental composition, to which the speckles adhere, bringing together such stream and another stream of such dental compositions so that they adhere together with the deposited speckles sandwiched between them, and controlling relative feed rates of the dental composition and the speckles so that there is produced a dentifrice containing the speckles distributed through it in desired proportion. Also described are apparatuses for carrying out the process.

Abstract: A radio receiver squelch circuit operative as a function of a comparison of the audio component level of the detected signal with the noise component level, so as to amplify and pass signals when the audio component exceeds the noise component by a predetermined ratio and to shunt the signals, thus squelching any output, when the noise component exceeds the audio component by a predetermined ratio. The circuit incorporates a hysteresis function such that the audio level required to initiate squelch is less than that required to break squelch.

Abstract: In a radio receiver, noise limiter apparatus specifically designed to clip impulse noise and to pass the audio signal undistorted up to about 80% carrier modulation. The noise limiter comprises a clipping circuit which is normally turned on by the audio signal to pass same, and a noise impulse amplifier branch containing an amplifier which is edgetriggered to cause clipping during the presence of noise impulses and to eliminate an output from the impulse amplifier when an audio signal is present.

Abstract: In order to produce signals having a desired communication channel frequency, a phase locked loop is provided, along with appropriate frequency division. For channels in the megahertz range having bandwidth in the kilohertz range, a kilohertz reference is provided for comparison, to drive the voltage controlled oscillator. The oscillator output is divided by the megahertz quantity, and by optional division multiples in the kilohertz channel range. In particular, a first division ratio is utilized for a portion of a reference cycle, and a second division ratio for the remainder of this cycle. Preloaded logic controls the two division rates, and by adjusting the portions of the cycle, correspondingly regulates the effective division ratio for the loop, and yields the proper channel frequency for locking.

Abstract: For use in a channel synthesizer utilizing a pulse swallowing phase locked loop, an eight bit code represents the megahertz component of the selected channel. An eight stage shift register is preloaded with the coded version of the selected megahertz component, and exclusive OR logic responsive selectively to the first, third, fifth, and eighth stages generates data for the first stage during the next shift. NAND logic responsive to the various stages detects presence of certain code combinations which are representative of terminal count states. Each terminal count pulse is utilized for comparison with the frequency reference in the phase locked loop, and also in a feedback arrangement to reset the registers to their preloaded states.