Patents by Inventor John F. Tisdale

John F. Tisdale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lentiviral vector for treating hemoglobin disorders
    Patent number: 11813316
    Abstract: The invention is directed to a more efficient lentiviral vector comprising a nucleic acid sequence encoding a human ?-globin protein or a human ?-globin protein, which is oriented from 5? to 3? relative to the lentiviral genome. The invention also provides a composition and method utilizing the lentiviral vector.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: November 14, 2023
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Naoya Uchida, John F. Tisdale
  • Lentiviral protein delivery system for RNA-guided genome editing
    Patent number: 11203768
    Abstract: The invention is directed to a system comprising a lentivirus vector particle which encodes at least one guide RNA sequence that is complementary to a first DNA sequence in a host cell genome, a Cas9 protein, and optionally a donor nucleic acid molecule comprising a second DNA sequence. The invention also is directed to a method of altering a DNA sequence in a host cell using such a system, where the host cell can be in a human and the altered DNA can be of the human ?-globin gene. The invention also is directed to a fusion protein comprising a Cas9 protein and a cyclophilin A (CypA) protein. The invention also is directed to sequences of vectors that can be used in the system and method.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: December 21, 2021
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Naoya Uchida, Juan J. Haro Mora, John F. Tisdale
  • LENTIVIRAL VECTOR FOR TREATING HEMOGLOBIN DISORDERS
    Publication number: 20200215167
    Abstract: The invention is directed to a more efficient lentiviral vector comprising a nucleic acid sequence encoding a human ?-globin protein or a human ?-globin protein, which is oriented from 5? to 3? relative to the lentiviral genome. The invention also provides a composition and method utilizing the lentiviral vector.
    Type: Application
    Filed: December 17, 2019
    Publication date: July 9, 2020
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Naoya Uchida, John F. Tisdale
  • Lentiviral vector for treating hemoglobin disorders
    Patent number: 10543257
    Abstract: The invention is directed to a more efficient lentiviral vector comprising a nucleic acid sequence encoding a human ?-globin protein or a human ?-globin protein, which is oriented from 5? to 3? relative to the lentiviral genome. The invention also provides a composition and method utilizing the lentiviral vector.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: January 28, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Naoya Uchida, John F. Tisdale
  • LENTIVIRAL PROTEIN DELIVERY SYSTEM FOR RNA-GUIDED GENOME EDITING
    Publication number: 20180223313
    Abstract: The invention is directed to a system comprising a lentivirus vector particle which encodes at least one guide RNA sequence that is complementary to a first DNA sequence in a host cell genome, a Cas9 protein, and optionally a donor nucleic acid molecule comprising a second DNA sequence. The invention also is directed to a method of altering a DNA sequence in a host cell using such a system, where the host cell can be in a human and the altered DNA can be of the human ?-globin gene. The invention also is directed to a fusion protein comprising a Cas9 protein and a cyclophilin A (CypA) protein. The invention also is directed to sequences of vectors that can be used in the system and method.
    Type: Application
    Filed: April 2, 2018
    Publication date: August 9, 2018
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Naoya Uchida, Juan J. Haro Mora, John F. Tisdale
  • LENTIVIRAL VECTOR FOR TREATING HEMOGLOBIN DISORDERS
    Publication number: 20170296630
    Abstract: The invention is directed to a more efficient lentiviral vector comprising a nucleic acid sequence encoding a human ?-globin protein or a human ?-globin protein, which is oriented from 5? to 3? relative to the lentiviral genome. The invention also provides a composition and method utilizing the lentiviral vector.
    Type: Application
    Filed: August 14, 2015
    Publication date: October 19, 2017
    Applicant: The United State of America, as represented by the Secretary, Department of Health and Human Service
    Inventors: Naoya Uchida, John F. Tisdale