Patents by Inventor John F Valliant

John F Valliant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MACROCYCLIC CHELATES AND USES THEREOF
    Publication number: 20210395281
    Abstract: The present disclosure relates to macrocyclic chelates including a macrocyclic chelating moiety of a metal complex thereof, a bifunctional linker, and a therapeutic or targeting moiety. Also disclosed are methods for preparation of the same, and use thereof.
    Type: Application
    Filed: January 8, 2021
    Publication date: December 23, 2021
    Inventors: Stuart J. Mahoney, Michael B. Johansen, Matthew D. Moran, Melissa Chassé, Ryan W. Simms, Eric S. Burak, John F. Valliant
  • METHODS FOR PURIFYING RADIOLABELLED COMPOUNDS
    Publication number: 20090005545
    Abstract: One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a radiolabel delivering compound to give a radiolabelled compound, wherein the fluoroalkyl tin moiety is replaced by a radiolabel; and c) eluting the radiolabelled compound from the fluorous polymer.
    Type: Application
    Filed: February 25, 2008
    Publication date: January 1, 2009
    Inventors: John F. Valliant, Peter Dorff, Raman Chirakal
  • Methods for purifying radiolabelled compounds
    Patent number: 7335347
    Abstract: One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a radiolabel delivering compound to give a radiolabelled compound, wherein the fluoroalkyl tin moiety is replaced by a radiolabel; and c) eluting the radiolabelled compound from the fluorous polymer.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: February 26, 2008
    Assignee: McMaster University
    Inventors: John F. Valliant, Peter Dorff, Raman Chirakal
  • Metal-carborane complexes for radioimaging and radiotherapy and methods for their preparation
    Patent number: 6890513
    Abstract: The present invention relates to a new method for the preparation of radiopharmaceuticals based on technetium and rhenium. The method involves the reaction of a salt of the formula [M(CO)3(Xm)3](1+3m), wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula [nido-(C2B9H11)]2? and functional derivatives thereof. The method has been shown to be applicable to the preparation of radiopharmaceuticals at the tracer level.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: May 10, 2005
    Assignee: McMaster University
    Inventors: John F Valliant, Pierre Morel, Paul Schaffer, Oyebola O. Sogbein
  • Methods for purifying radiolabelled compounds
    Publication number: 20040260073
    Abstract: One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a radiolabel delivering compound to give a radiolabelled compound, wherein the fluoroalkyl tin moiety is replaced by a radiolabel; and c) eluting the radiolabelled compound from the fluorous polymer.
    Type: Application
    Filed: October 16, 2003
    Publication date: December 23, 2004
    Inventors: John F. Valliant, Peter N. Dorff, Raman Chirakal
  • Metal-carborane complexes for radioimaging and radiotherapy and methods for their preparation
    Publication number: 20030068271
    Abstract: The present invention relates to a new method for the preparation of radiopharmaceuticals based on technetium and rhenium. The method involves the reaction of a salt of the formula [M(CO)3(Xm)3](1+3m), wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula [nido-(C2B9H11)]2− and functional derivatives thereof. The method has been shown to be applicable to the preparation of radiopharmaceuticals at the tracer level.
    Type: Application
    Filed: May 24, 2002
    Publication date: April 10, 2003
    Inventors: John F. Valliant, Pierre Morel, Paul Schaffer, Oyebola O. Sogbein