Patents by Inventor John F. Wironen
John F. Wironen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9332750Abstract: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: GrantFiled: March 11, 2014Date of Patent: May 10, 2016Assignee: RTI Surgical, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Publication number: 20140193798Abstract: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: ApplicationFiled: March 11, 2014Publication date: July 10, 2014Applicant: RTI Surgical, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Patent number: 8669043Abstract: A method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant, and the implant produced by such treatment. A system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants. Goals include between about a one to twelve log reduction in bacterial contamination, between about a one to fifteen log reduction in enveloped virus contamination, up to about a five log reduction in non-enveloped virus contamination, between about a two to tenfold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.Type: GrantFiled: February 17, 2012Date of Patent: March 11, 2014Assignee: RTI Surgical, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Patent number: 8652503Abstract: A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-?, PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).Type: GrantFiled: June 14, 2005Date of Patent: February 18, 2014Assignees: University of Florida Research Foundation, Inc., Regeneration Technologies, Inc.Inventors: John F. Wironen, Jamie M. Grooms
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Publication number: 20120323324Abstract: Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blacks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.Type: ApplicationFiled: August 23, 2012Publication date: December 20, 2012Inventors: Davna Buskirk, Chris Seid, John F. Wironen, James M. Gross, Gina Scurti
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Publication number: 20120214149Abstract: A method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant, and the implant produced by such treatment. A system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants. Goals include between about a one to twelve log reduction in bacterial contamination, between about a one to fifteen log reduction in enveloped virus contamination, up to about a five log reduction in non-enveloped virus contamination, between about a two to tenfold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.Type: ApplicationFiled: February 17, 2012Publication date: August 23, 2012Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Patent number: 8142991Abstract: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: GrantFiled: February 19, 2009Date of Patent: March 27, 2012Assignee: RTI Biologics, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Publication number: 20110301707Abstract: Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blacks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.Type: ApplicationFiled: October 29, 2008Publication date: December 8, 2011Inventors: Davna Buskirk, Chris Seid, John F. Wironen, James M. Gross, Gina Scurti
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Patent number: 7824702Abstract: Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes. Alternatively, a mixing syringe is disclosed, which is useful for reconstituting a paste, inter alia, comprising a flexible midportion, whereby repeated compression of the flexible midportion results in mixing the contents of the syringe.Type: GrantFiled: February 5, 2008Date of Patent: November 2, 2010Assignee: RTI Biologics, Inc.Inventors: John F. Wironen, Penelope Kao, Andy Bernhardt
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Publication number: 20090186333Abstract: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: ApplicationFiled: February 19, 2009Publication date: July 23, 2009Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke
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Patent number: 7513910Abstract: Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.Type: GrantFiled: December 8, 2004Date of Patent: April 7, 2009Assignee: RTI Biologics, Inc.Inventors: Dayna Buskirk, Christopher A. Seid, John F. Wironen, James M. Gross, Gina Scurti
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Publication number: 20080124397Abstract: Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes. Alternatively, a mixing syringe is disclosed, which is useful for reconstituting a paste, inter alia, comprising a flexible midportion, whereby repeated compression of the flexible midportion results in mixing the contents of the syringe.Type: ApplicationFiled: February 5, 2008Publication date: May 29, 2008Applicant: REGENERATION TECHNOLOGIES, INC.Inventors: John F. Wironen, Penelope Kao, Andy Bernhardt
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Patent number: 7153518Abstract: Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.Type: GrantFiled: August 27, 2002Date of Patent: December 26, 2006Assignee: Regeneration Technologies, Inc.Inventors: John F. Wironen, Chris Seid, Rebecca Jaw, Thien Doan, Gregg Ritter, Russell S. Donda
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Patent number: 6893462Abstract: Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.Type: GrantFiled: August 29, 2001Date of Patent: May 17, 2005Assignee: Regeneration Technologies, Inc.Inventors: Dayna Buskirk, Chris Seid, John F. Wironen, James M. Gross, Gina Scurti
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Patent number: 6685626Abstract: Disclosed and claimed are compositions, devices, methods and kits that are useful in surgical procedures, specifically to induce adhesions for the purposes of stabilizing implants, closing apertures, and otherwise promoting the adhesion of implants and anatomical structures to one another. The invention pertains to a composition containing specific particulate components, wherein the particulates promote an inflammatory reaction that results in the formation of an adhesion.Type: GrantFiled: February 2, 2001Date of Patent: February 3, 2004Assignee: Regeneration Technologies, Inc.Inventor: John F. Wironen
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Patent number: 6652818Abstract: This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: GrantFiled: August 20, 1999Date of Patent: November 25, 2003Assignee: Regeneration Technologies, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke, Russell S. Donda, Jamie M. Grooms
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Publication number: 20030180262Abstract: Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes. Alternatively, a mixing syringe is disclosed, which is useful for reconstituting a paste, inter alia, comprising a flexible midportion, whereby repeated compression of the flexible midportion results in mixing the contents of the syringe.Type: ApplicationFiled: October 11, 2001Publication date: September 25, 2003Inventors: John F. Wironen, Penelope Kao, Andy Bernhardt
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Patent number: 6613278Abstract: This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: GrantFiled: September 7, 1999Date of Patent: September 2, 2003Assignee: Regeneration Technologies, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke, Russell S. Donda, Jamie M. Grooms, John Bianchi
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Publication number: 20030104026Abstract: Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.Type: ApplicationFiled: August 27, 2002Publication date: June 5, 2003Inventors: John F. Wironen, Christopher A. Seid, Rebecca Jaw, Thien Doan, Gregg Ritter, Russell S. Donda
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Publication number: 20030027125Abstract: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: ApplicationFiled: July 10, 2002Publication date: February 6, 2003Applicant: Regeneration Technologies, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke