Abstract: Computer based systems and methods for estimating a user state are disclosed. In some embodiments, the methods comprise inputting a first input at an intermittent interval and a second input at a frequent interval into a user state estimation model to estimate the user state. In some embodiments, the first inputs are enhanced by injecting a noise input to create a plurality of enhanced first inputs whereby the plurality of enhance first inputs correspond to the plurality of second inputs at the frequent interval. In some embodiments, the first input comprises a self-reported input and the second inputs comprise a physiological input, a performance input or a situational input. In some embodiments, a machine learning algorithm creates the state estimation model. In some embodiments, the state estimation model estimates a future user state. In some embodiments, a computer based system for estimating a user state is provided.

Abstract: In one example embodiment of the invention, a simulation based training system is provided having a sensor that unobtrusively collects objective data for individuals and teams experiencing training content to determine the cognitive states of individuals and teams; time-synchronizes the various data streams; automatically determines granular and objective measures for individual cognitive load (CL) of individuals and teams; and automatically determines a cognitive load balance (CLB) and a relative cognitive load (RCL) measure in real or near-real time. Data is unobtrusively gathered through physiological or other activity sensors such as electroencephalogram (EEG) and electrocardiogram (ECG) sensors. Some embodiments are further configured to also include sociometric data in the determining cognitive load. Sociometric data may be obtained through the use of sociometric badges.

Abstract: A contextualized sensor system is provided comprising one or more sensors, one or more memory elements, a library of alert rules stored in the one or more memory elements, one or more processors, and the one or more memory elements including instructions that, when executed, cause the one or more processors to perform operations comprising: receiving from one of the one or more sensors one or more sensor data, comparing the first sensor data to a library of alert rules to determine whether an alert situation has occurred, and communicating an alert if the alert situation has occurred. In some embodiments, the operations further comprise contextualizing an environmental data, a location data, a physiological data, a behavior data and an orientation data.

Abstract: Computer based systems and methods for estimating a user state are disclosed. In some embodiments, the methods comprise inputting a first input at an intermittent interval and a second input at a frequent interval into a user state estimation model to estimate the user state. In some embodiments, the first inputs are enhanced by injecting a noise input to create a plurality of enhanced first inputs whereby the plurality of enhance first inputs correspond to the plurality of second inputs at the frequent interval. In some embodiments, the first input comprises a self-reported input and the second inputs comprise a physiological input, a performance input or a situational input. In some embodiments, a machine learning algorithm creates the state estimation model. In some embodiments, the state estimation model estimates a future user state. In some embodiments, a computer based system for estimating a user state is provided.

Abstract: Computer based systems and methods for estimating a user state are disclosed. In some embodiments, the methods comprise inputting a first input at an intermittent interval and a second input at a frequent interval into a user state estimation model to estimate the user state. In some embodiments, the first inputs are enhanced by injecting a noise input to create a plurality of enhanced first inputs whereby the plurality of enhance first inputs correspond to the plurality of second inputs at the frequent interval. In some embodiments, the first input comprises a self-reported input and the second inputs comprise a physiological input, a performance input or a situational input. In some embodiments, a machine learning algorithm creates the state estimation model. In some embodiments, the state estimation model estimates a future user state. In some embodiments, a computer based system for estimating a user state is provided.

Abstract: An apparatus for controlling a composite fabric having internal axial tows includes a support member configured to engage the fabric substantially up to a composite component form. The support member includes a nonslip portion directly engaging a first outer surface of the fabric. The apparatus further includes a primary securing member engaging and applying pressure on the fabric at a second outer surface of the fabric opposite the first outer surface. Upon displacement of the axial tows of the fabric relative to the first and second outer surfaces, the support member and the primary securing member substantially maintain original configurations of the first and second outer surfaces of the fabric engaged between the support member and the primary securing member.

Abstract: In a composite component having a laminate body, a conductive layer and a connector can be joined to one another using an intermediate flexible circuit. Among other things, this flexible circuit places the conductive layer and the connector in electrical communication with one another. Furthermore, during the forming process and because of its thinness, the flexible circuit integrates well with the layers of the laminate body and can accommodates some spatial displacement of the connector and conductive material relative to one another.

Abstract: Disclosed are methods and devices for the formation of fabric preforms that may be subsequently impregnated with a resin to form a composite component. One end of the fabric is received on the form such that the axial tows of the fabric extend in a direction generally perpendicular to a central axis of the form. At least some of the plurality of axial tows are separately tensioned on an end of the fabric not attached to the form and the fabric is wrapped around the form by rotating the fabric and form relative to one another about the central axis.

Abstract: An apparatus for controlling a composite fabric having internal axial tows includes a support member configured to engage the fabric substantially up to a composite component form. The support member includes a nonslip portion directly engaging a first outer surface of the fabric. The apparatus further includes a primary securing member engaging and applying pressure on the fabric at a second outer surface of the fabric opposite the first outer surface. Upon displacement of the axial tows of the fabric relative to the first and second outer surfaces, the support member and the primary securing member substantially maintain original configurations of the first and second outer surfaces of the fabric engaged between the support member and the primary securing member.

Abstract: Computer based systems and methods for estimating a user state are disclosed. In some embodiments, the methods comprise inputting a first input at an intermittent interval and a second input at a frequent interval into a user state estimation model to estimate the user state. In some embodiments, the first inputs are enhanced by injecting a noise input to create a plurality of enhanced first inputs whereby the plurality of enhance first inputs correspond to the plurality of second inputs at the frequent interval. In some embodiments, the first input comprises a self-reported input and the second inputs comprise a physiological input, a performance input or a situational input. In some embodiments, a machine learning algorithm creates the state estimation model. In some embodiments, the state estimation model estimates a future user state. In some embodiments, a computer based system for estimating a user state is provided.

Abstract: The present invention provides pro-drugs of D-gamma-glutamyl-[D/L]-tryptophan, said pro-drugs are compounds of Formula I or pharmaceutically acceptable salts thereof, wherein G is C1-C8 alkyl or benzyl, T is C1-C8 alkyl or benzyl, and * is a chiral carbon in a (R) or (S) configuration, provided that when * is in the (R) configuration, at least one of G and T is C5-C8 alkyl; and use of compounds of Formula I in a pharmaceutical composition.

Abstract: Provided are carboxylic ester derivatives of formula (I), methods of preparing them, and methods for using them. These compounds are prodrugs of D-isoglutamyl-[D/L]-tryptophan. The in vitro bioconversion of some of the prodrugs to the parent drug D-isoglutamyl-D-tryptophan (or thymodepressin) was tested in human hepatocytes and in human blood. In vivo pharmacokinetic studies following oral administration of some of the prodrugs to rats are also reported.

Abstract: Disclosed are a method and an apparatus for applying a compaction pressure to a fabric during formation of a fabric preform. One end of the fabric is applied to the form having a central axis. The form with the fabric applied thereto is at least partially surrounded with a film. This film extends along a film path to the form and around at least a portion of the form. The fabric and the film are fed onto the form such that the fabric is wrapped around the form to create the fabric preform while the film is fed around the form. A vacuum is drawn to evacuate a gas from between the form and the film, thereby pressing the film onto the fabric and applying the compaction pressure to the fabric.

Abstract: In a composite component having a laminate body, a conductive layer and a connector can be joined to one another using an intermediate flexible circuit. Among other things, this flexible circuit places the conductive layer and the connector in electrical communication with one another. Furthermore, during the forming process and because of its thinness, the flexible circuit integrates well with the layers of the laminate body and can accommodates some spatial displacement of the connector and conductive material relative to one another.

Abstract: Disclosed are methods and devices for the formation of fabric preforms that may be subsequently impregnated with a resin to form a composite component. One end of the fabric is received on the form such that the axial tows of the fabric extend in a direction generally perpendicular to a central axis of the form. At least some of the plurality of axial tows are separately tensioned on an end of the fabric not attached to the form and the fabric is wrapped around the form by rotating the fabric and form relative to one another about the central axis.

Abstract: Disclosed are a method and an apparatus for applying a compaction pressure to a fabric during formation of a fabric preform. One end of the fabric is applied to the form having a central axis. The form with the fabric applied thereto is at least partially surrounded with a film. This film extends along a film path to the form and around at least a portion of the form. The fabric and the film are fed onto the form such that the fabric is wrapped around the form to create the fabric preform while the film is fed around the form. A vacuum is drawn to evacuate a gas from between the form and the film, thereby pressing the film onto the fabric and applying the compaction pressure to the fabric.

Abstract: A preforming device and method of use thereof, the device including a rack, a pinion, belt, belt tensioning feature, and mechanism for supporting a variably appliable enhanced pressure, such as may be applied using a bladder or bladders having one or more valves, the device capable of engaging a mandrel to form at least one ply and a binder against the exterior of the mandrel.

Abstract: Provided are compounds which are prodrugs of D-gamma-glutamyl-D-tryptophan, methods of making the compounds and methods for using the compounds.

Abstract: Various connectors are provided that allow establishment of one or more connections in minimal space. Numerous pins of typical radial pin related art connectors are replaced with longitudinally extending connector portions that are able to matingly engage a receiving connector portion. The connectors ease the initial manufacture of parts in which they are used, and allows the part to be more easily maintained, lighten the wiring system or harnessing system for the final product in which the part is incorporated over conventional connectors, and typically permit the harness and wiring system for the product to fit within an allotted envelope for size, weight, and other limitations.

Abstract: A mandrel comprising a rigid inner core and an elastomeric outer layer that at least partially surrounds the rigid inner core, wherein the elastomeric outer layer is adapted to expand during a molding process to seal a cavity to prevent incursion of material injected during the molding process.