Patents by Inventor John Ferdinand Bol

John Ferdinand Bol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic fungal resistant plants expressing chitinase and glucanase, process for obtaining, and recombinant polynucleotides for uses therein
    Patent number: 6087560
    Abstract: Plants are provided with improved resistance against pathogenic fungi. They are genetically transformed with one or more polynucleotides which essentially comprise one or more genes encoding plant chitinases and .beta.-1,3-glucanases. Preferred are the intracellular forms of the said hydrolytic enzymes, especially preferred are those forms which are targeted to the apoplastic space of the plant by virtue of the modification of the genes encoding the said enzymes. Particularly preferred are plants exhibiting a relative overexpression of at least one gene encoding a chitinase and one gene encoding a .beta.-1,3-glucanase.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: July 11, 2000
    Assignees: Rijksuniversiteit te Leiden, Mogen International, N.V.
    Inventors: Bernardus J. C. Cornelissen, Leo Sjoerd Melchers, Elisabeth J. S. Meulenhoff, Jeroen S. C. van Roekel, Marianne Beatrix Sela-Buurlage, Alexandra Aleida Vloemans, Charles Peter Woloshuk, John Ferdinand Bol, Hubertus J. M. Linthorst
  • Chitinase, DNA coding therefor and plants containing same
    Patent number: 5993808
    Abstract: There is provided a method for inhibiting growth and/or germination of a fungus, by contacting the fungus, or causing the fungus to be contacted with a composition including an effective amount of a pathogenesis-related protein occurring naturally in a plant. The protein has endochitinase activity, antifungal activity and a molecular weight of about 40 to 43 kDa as judged by Sodium Dodecyl Sulphate Polyacrylamide electrophoresis. There is also provided a composition for inhibiting growth and/or germination of a fungus. The composition includes a pathogenesis-related protein occurring naturally in a plant. The protein has endochitinase activity, antifungal activity and a molecular weight of about 40 to 43 kDa as judged by Sodium Dodecyl Sulphate Polyacrylamide electrophoresis. The composition also includes .beta.-1,3-glucanase in an amount sufficient to enhance the effectiveness of the composition in inhibiting the growth or germination of the fungus.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: November 30, 1999
    Assignees: Mogen International NV, Rijksuniversiteit Te Leiden
    Inventors: Leo Sjoerd Melchers, Marion Apotheker-De Groot, John Ferdinand Bol, Bernardus Johannes Clemens Cornelissen, Hubertus Josephus Maria Linthorst, Anne Silene Ponstein, Marianne Beatrix Sela-Buurlage
  • Fungal resistant plants, process for obtaining fungal resistant plants and recombinant polynucleotides for use therein
    Patent number: 5670706
    Abstract: Plants are provided with improved resistance against pathogenic fungi. They are genetically transformed with one or more polynucleotides which essentially comprise one or more genes encoding plant chitinases and .beta.-1,3-glucanases. Preferred are the intracellular forms of the said hydrolytic enzymes, especially preferred are those forms which are targeted to the apoplastic space of the plant by virtue of the modification of the genes encoding the said enzymes. Particularly preferred are plants exhibiting a relative overexpression of at least one gene encoding a chitinase and one gene encoding a .beta.-1,3-glucanase.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: September 23, 1997
    Assignees: MOGEN International, n.v., Rijksuniversiteit te Leiden
    Inventors: Bernardus J. C. Cornelissen, Leo Sjoerd Melchers, Elisabeth J. S. Meulenhoff, Jeroen S. C. van Roekel, Marianne Beatrix Sela-Buurlage, Alexandra Aleida Vloemans, Charles Peter Woloshuk, John Ferdinand Bol, Hubertus J. M. Linthorst