Abstract: Inflammatory disorders, including obliterative airway disease, renal fibrosis, diabetic nephropathy, and liver fibrosis are treated with immunosuppressive triptolide compounds, in particular triptolide compounds effective to inhibit TGF-? production in a patient afflicted with such a disorder.

Abstract: A projectile for dispersing a riot control agent material into the atmosphere at a target. The projectile is designed to open in flight and scatter a number of independent dispersal charges over a limited target area, and comprises a sabot in the form of a number of segments which are locked together prior to launching, which contains the dispersal charges and a delayed opening means which initiates opening in flight, thereby releasing the charges along approximately the same trajectory as the former projectile. In a preferred embodiment the sabot is cylindrical, in two segments hinged together at their rear end, locked together by either a collar or a pin and socket arrangement, and containing a number of cylindrical charges in line, with an axial channel. The projectile is fired from a gun, and firing initiates a pyrotechnic delay which activates an explosive or pyrotechnic charge in the channel and between the charges to open the sabot and activate and disperse the charges.