Abstract: A series of substituted imidazo[1,2-b]pyridazine derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: Briefly, a kinkless infusion set has a setting control that engages a curved or helical cannula to simultaneously rotate the helical cannula as the helical cannula is moved toward a patients skin and then under the patient's skin to position the curved or helical cannula to a desired depth and position. In one example, the helical cannula is set between 3 mm and 5 mm under the patient's skin. Also, the curved or helical cannula may have side ports to allow medicine to be presented over a larger area for more effective therapeutic treatment. In some constructions the patient rotates the setting control, and in other cases the patient may push, pull or translate the setting control.

Abstract: Briefly, a kinkless infusion set has a setting control that engages a curved or helical cannula to simultaneously rotate the helical cannula as the helical cannula is moved toward a patients skin and then under the patient's skin to position the curved or helical cannula to a desired depth and position. In one example, the helical cannula is set between 3 mm and 5 mm under the patient's skin. Also, the curved or helical cannula may have side ports to allow medicine to be presented over a larger area for more effective therapeutic treatment. In some constructions the patient rotates the setting control, and in other cases the patient may push, pull or translate the setting control.

Abstract: Disclosed herein are surgical staple line reinforcement materials and methods of production and use thereof.

Abstract: A head utility system (20) comprising: a headset (22) comprising: a first power or data connector (28) for connecting to an off-headset power or data system (30); and a second power or data connector (38); the head utility system further comprising: headwear (24) for wearing over the headset, the headwear comprising: a headwear power or data connector (44) for connecting to the second power or data connector; wherein the second connector and the headwear connector are arranged to be releasably connected when the headwear is worn over the headset, such that power or data can be transferred between the headset and the headwear.

Abstract: An exercise machine includes a processor, a first display, a deck, and a belt rotatable about the deck. The machine also includes a sensor operably connected to the processor and configured to detect a first performance parameter of a first user running on the belt of the exercise machine. The processor is configured to receive information indicative of a second performance parameter of a second user, the second performance parameter being detected at an additional exercise machine during display of the at least part of the exercise class on a display associated with the additional exercise machine. The processor is also configured to cause the second performance parameter to be displayed on the first display together with the first performance parameter.

Abstract: A composition for reducing or preventing development of one or more symptoms of alcohol consumption includes at least prickly pear extract, reduced L-Glutathione, N-Acetyl-L-Cysteine (NAC), licorice root extract, and milk thistle, which are present in the composition in effective amounts sufficient in combination to reduce or prevent development of one or more detrimental symptoms of alcohol consumption. Also disclosed are methods of reducing or prevent the development of detrimental symptoms of alcohol consumption using the compositions.

Abstract: A method includes receiving a video input, receiving an indication of a first segment type corresponding to a first workout activity being performed in the video input, and generating a segmented timeline with the processor, the segmented timeline including a plurality of segments, and at least one segment of the plurality of segments corresponding to the first workout activity. The method further includes generating a user interface with the processor, the user interface including the segmented timeline displayed together with at least part of the video input. The method also includes providing the user interface to a plurality of exercise machines via a network.

Abstract: A composition for reducing or preventing development of one or more symptoms of alcohol consumption includes at least prickly pear extract, reduced L-Glutathione, N-Acetyl-L-Cysteine (NAC), licorice root extract, and milk thistle, which are present in the composition in effective amounts sufficient in combination to reduce or prevent development of one or more detrimental symptoms of alcohol consumption. Also disclosed are methods of reducing or prevent the development of detrimental symptoms of alcohol consumption using the compositions.

Abstract: A display system is described, for placement of a display above, below or beside the normal gaze of a user, to impart simple information to the user by means of selective driving of a plurality of light emitting elements.

Abstract: A catheter includes a catheter body and a distal tip section that includes an elongated member that extends along a longitudinal axis. An anchor mechanism can be disposed along an outer surface of the elongated member and/or within the elongated member in a first configuration. In a second configuration, the anchor mechanism can be configured to extend radially outward with respect to the longitudinal axis to surround at least a portion of the distal tip section.

Abstract: Briefly, a kinkless infusion set has a setting control that engages a curved or helical cannula to simultaneously rotate the helical cannula as the helical cannula is moved toward a patients skin and then under the patient's skin to position the curved or helical cannula to a desired depth and position. In one example, the helical cannula is set between 3 mm and 5 mm under the patient's skin. Also, the curved or helical cannula may have side ports to allow medicine to be presented over a larger area for more effective therapeutic treatment. In some constructions the patient rotates the setting control, and in other cases the patient may push, pull or translate the setting control.

Abstract: A head utility system (20) comprising: a headset (22) comprising: a first power or data connector (28) for connecting to an off-headset power or data system (30); and a second power or data connector (38); the head utility system further comprising: headwear (24) for wearing over the headset, the headwear comprising: a headwear power or data connector (44) for connecting to the second power or data connector; wherein the second connector and the headwear connector are arranged to be releasably connected when the headwear is worn over the headset, such that power or data can be transferred between the headset and the headwear.

Abstract: A method includes receiving, with a processor in communication with a first exercise machine, a first request for an exercise class, the first request being provided by a first user of the first exercise machine. The method also includes providing a video file associated with the exercise class to the first exercise machine, providing a notification to a second user indicating that the first user has chosen to participate in the exercise class, and receiving a second request for the exercise class provided by the second user. The method further includes providing the video file to a second exercise machine of the second user via the network. In such a method, display of the video file via a display of the second exercise machine is synchronized with display of the video file via a display of the first exercise machine.

Abstract: An exercise machine includes a processor, a first display, a deck, and a belt rotatable about the deck. The machine also includes a sensor operably connected to the processor and configured to detect a first performance parameter of a first user running on the belt of the exercise machine. The processor is configured to receive information indicative of a second performance parameter of a second user, the second performance parameter being detected at an additional exercise machine during display of the at least part of the exercise class on a display associated with the additional exercise machine. The processor is also configured to cause the second performance parameter to be displayed on the first display together with the first performance parameter.

Abstract: A probabilistic framework to detect controversy on the web. The prior kNN-WC algorithm is recast into a theoretical framework and a new language model introduced. Language models are constructed that are used to calculate probabilities. The probabilities are compared to determine whether or not a certain document is controversial.

Abstract: An infusion set has an insertion device that inserts a cannula and introducer needle fully into a patient, and then fully removes the introducer needle with one user motion. In some examples the insertion device does not permit partial insertion or incomplete introducer element removal.