Abstract: The present invention relates to a process for the preparation of synthetic intermediates which may be used in the preparation of tetrahydroquinoline derivatives, which derivatives have an inhibitory activity against cholesteryl transfer protein (CETP), show effects of increasing HDL cholesterol level and decreasing LDL cholesterol level, and can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, hyperlipidemia, dyslipidemia and the like.

Abstract: Self-heating containers comprise a reaction chamber and a heating chamber. The heating chamber is sized to contain a substance to be heated. The reaction chamber contains reactants which, when contacted, exothermically react. The reaction chamber is divided into a first compartment and a second compartment with a barrier therebetween. The barrier comprises a first barrier portion and a second barrier portion. The first barrier portion is attached to a reaction chamber wall and has an opening sized to allow reactants to flow through from one compartment to the other. The second barrier portion is attached to the first barrier portion to close the opening. The barrier can be opened by moving an actuator into engagement with the second barrier portion to dislodge the second barrier portion from the first barrier portion and thereby open the barrier. In certain embodiments, the heating chamber can be a can with prepackaged comestible substance therein.

Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (hereinafter referred to as Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.

Abstract: Self-heating containers comprise a reaction chamber and a heating chamber. The heating chamber is sized to contain a substance to be heated. The reaction chamber contains reactants which, when contacted, exothermically react. The reaction chamber is divided into a first compartment and a second compartment with a barrier therebetween. The barrier comprises a first barrier portion and a second barrier portion. The first barrier portion is attached to a reaction chamber wall and has an opening sized to allow reactants to flow through from one compartment to the other. The second barrier portion is attached to the first barrier portion to close the opening. The barrier can be opened by moving an actuator into engagement with the second barrier portion to dislodge the second barrier portion from the first barrier portion and thereby open the barrier. In certain embodiments, the heating chamber can be a can with prepackaged comestible substance therein.

Abstract: A working toolkit includes an extendible shaft, a tool handle and a tool head, each having connection formations so that the tool handle may be releasably attached to one end of the shaft, and the tool head may be releasably attached to an opposite end of the shaft to form a working tool, and thereafter disassembled for storage and transportation in a compact form. The tool handle may be directly releasably attached directly to the tool head. A variety of connection formations are provided, particularly adapted for a tubular shaft. The working toolkit may include several different tool handles and tool heads for selectively forming a variety of working tools.

Abstract: The present invention is generally applicable to a container. More specifically, the invention is applicable to a waste container for the collection, storage and transport of waste and refuse material. The waste containers of the present invention are particularly useful for the collection, storage and transporting of organic waste material.

Abstract: The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein X1, R1, R2, R3, R4, and R5 are defined as set forth in the specification. The compounds are useful as potassium ion channel inhibitors.

Abstract: An electrosurgical instrument is provided for the treatment of tissue, the instrument comprising an instrument shaft (10) having a longitudinal axis, and an electrode assembly at one end of the shaft. The electrode assembly comprises first and second active electrodes (11), (14) and at least one return electrode (25), the electrodes being electrically insulated one from another by means of one or more insulation members (12). The first and second active electrodes (11, 14) each have an exposed surface for treating tissue, the exposed surface (19) of the first active electrode being such as to treat tissue disposed laterally of the longitudinal axis at a first radial position with respect to the instrument shaft. The exposed surface (15) of the second active electrode is such as to treat tissue disposed laterally of the longitudinal axis at a second radial position with respect to the instrument shaft.

Abstract: Systems and methods are provided for initiation, use, access, and control of functionality of a network. In one aspect, the systems and methods can be utilized to generate information defining signaling or control performance and operational characteristics associated with the functionality in a variety of network environments. In another aspect, based on such information, adaptive signaling can be utilized to monitor, analyze and detect specific signaling signatures associated with the functionality. Managing signaling or control messages in response to information collected by monitoring and analyzing the adaptive signaling permits originating or requesting the functionality without conventional operation of a network component.

Abstract: Systems and methods for receiving, processing and responding to text messages are described. In one embodiment a central business unit (CBU) response system may include apparatus for receiving text messages from a message sender, storing the messages in a memory, providing a user indication of receipt of the text messages, displaying and/or printing the message contents, receiving a user input in response to the user indication, and providing a confirmation message to the message sender.

Abstract: An apparatus for sealing a hole in a wall (4), the wall in use dividing a region of relative high pressure from a region of relative low pressure, the apparatus comprising an elongate stem (2) connected at one end to a sealing member (3) which extends substantially radially from the major axis of said stem in an extended state such that, in use, said relative high pressure acts to seal the sealing member in the extended state against the wall, wherein said sealing member is resiliently deformable from said extended state into a collapsed state in which the sealing member is folded towards the stem, and into an everted state in which the sealing means is folded away from the stem. Said sealing member may when in its extended state form a dome shape which acts to maintain an air gap around the hole.

Abstract: The present invention relates to thienopyrimidine compounds which are potassium channel inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment of arrhythmia are also described.

Abstract: The present invention provides thienopyridine compounds which are potassium channel inhibitors. In another embodiment, the invention provides pharmaceutical compositions comprising thienopyridines. In another embodiment, the invention provides methods of using thienopyridines in the treatment or prevention of cancer, arrhythmias, autoimmune diseases and inflammatory diseases, including gastric cancer, atrial fibrillation, type-2 diabetes mellitus, rheumatoid arthritis, type-1 diabetes, inflammatory bowel disorder and demyelinating disorders such as multiple sclerosis.