Abstract: A flow through aerobic granular sludge (AGS) system includes a flow through reactor. The flow through reactor includes a first adsorption zone, first and second unaerated and aerated zones, and a wastewater distribution system. The first adsorption zone includes AGS granules introduced to a top of the first adsorption zone. The first and second unaerated zones are under anaerobic, anoxic, or both anaerobic and anoxic conditions. The first and second aerated zones are under aerobic conditions. The wastewater distribution system includes a distribution grid of piping or an underdrain system at a bottom of the adsorption zone. The flow through reactor is configured such that, in operation, the wastewater and AGS granules flow continuously from the first adsorption zone through the first unaerated zone, the first aerated zone, the second unaerated zone, and the second aerated zone.

Abstract: A flow through aerobic granular sludge (AGS) system includes a flow through reactor. The flow through reactor includes a first adsorption zone and first and second unaerated and aerated zones and may include a wastewater distribution system and a selector zone. The first adsorption zone includes AGS granules and may include a mixing device. The first and second unaerated zones are under anaerobic, anoxic, or both anaerobic and anoxic conditions and each may include a mixing device. The first and second aerated zones are under aerobic conditions and each may include an aeration device. The flow through reactor is configured such that the wastewater and AGS granules in the first adsorption zone flow continuously from the first adsorption zone through the first unaerated zone, the first aerated zone, the second unaerated zone, the second aerated zone, and optionally to the selector zone and out of the flow through reactor.

Abstract: Embodiments of the presently disclosed technology provide orthopedic braces that employ adaptive/variable stiffness metamaterials to emulate the strain-stiffening behavior of ligaments. These orthopedic braces may provide lower rigidity during low-demand/low-strain activities (e.g., normal gait movements) and increased rigidity under high-demand/high-strain activities (e.g., running and other movements that require larger ranges of motion and rotational velocities).

Abstract: The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.

Abstract: The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.

Abstract: The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.

Abstract: A treatment system and method for removal of nutrients and other pollutants to produce a low solid, high quality effluent suitable for discharge or reuse using a combination of aerobic granular sludge (AGS), either in a sequencing batch reactor (SBR) AGS configuration or in a flow through AGS configuration, in combination with immersed/submerged membranes commonly referred to as membrane bio-reactor (MBR) wastewater treatment processes, systems, and methods.

Abstract: A flow through aerobic granular sludge (AGS) system includes a flow through reactor. The flow through reactor includes a first adsorption zone and first and second unaerated and aerated zones and may include a wastewater distribution system and a selector zone. The first adsorption zone includes AGS granules and may include a mixing device. The first and second unaerated zones are under anaerobic, anoxic, or both anaerobic and anoxic conditions and each may include a mixing device. The first and second aerated zones are under aerobic conditions and each may include an aeration device. The flow through reactor is configured such that the wastewater and AGS granules in the first adsorption zone flow continuously from the first adsorption zone through the first unaerated zone, the first aerated zone, the second unaerated zone, the second aerated zone, and optionally to the selector zone and out of the flow through reactor.

Abstract: A delivery device for use in administering a dry powder to a biological subject's airway is provided. The device comprises (a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; and (b) one or more cantilever structures located within the housing. Vibration of the one or more cantilever structures facilitates entry of the dry powder into the flow of gas, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway. Also provided is a container for releasably storing a particulate composition, the container comprising a shell sealed by a seal in which the particulate composition is stored, wherein a puncturing device for rupturing the seal to release the particulate composition is housed within the shell. Further provided are associated methods for administering dry powder using the delivery device and/or container.

Abstract: The present invention provides a poly(ethylene) glycol based polyurethane polymer composition, particularly useful in the production of contact lenses. Generally the reactant mixture used to form the polymer includes a branched chain extender. There is also provided a method of manufacturing a contact lens formed from such a polymer.

Abstract: This disclosure relates to a fire-retardant composite material comprising a fibre-reinforced plastic covered by an aluminium foil and its application in passenger transport industries such as aerospace, railway or marine.

Abstract: Described is a method of treating wastewater. The method includes receiving the wastewater at a ballasted activated sludge secondary treatment aeration basin. The method also includes adding a ballast material to the wastewater, treating the wastewater in the ballasted activated sludge secondary treatment aeration basin to produce a ballasted mixed liquor effluent, receiving the ballasted mixed liquor effluent at a high-rate heavy solids removal zone that includes one or more high-rate heavy solids removal units, and removing ballasted heavy solids from the ballasted mixed liquor effluent using the one or more high-rate heavy solids removal units to produce a concentrated ballasted heavy solids effluent and a clarified liquid effluent. Also described is a system for treating wastewater including a ballasted activated sludge secondary treatment aeration basin and a high-rate heavy solids removal zone for treating a ballasted mixed liquor effluent.

Abstract: A squeeze packer (1) assembly incorporates a built-in setting tool which removes the need for a separate setting tool. The packer comprises a body comprising a mandrel (9), a shuttle sleeve (7), and a stinger (2) assembly which is lowered into the wellbore on the end of tubing (102). The shuttle sleeve is housed within the body and incorporates a latch device in the form of a collet comprising a plurality of resilient fingers (14) to releasably connect to the stinger. A ball seat (15) allows hydraulic setting of slips (3). Additional slips (4) can be set by applying tension on the tubing (FIG. 4). Once released, the stinger can open and close the shuttle sleeve by reciprocating in and out of the packer as many times as required during cementing operations.

Abstract: A squeeze packer (1) assembly incorporates a built-in setting tool which removes the need for a separate setting tool. The packer comprises a body comprising a mandrel (9), a shuttle sleeve (7), and a stinger (2) assembly which is lowered into the wellbore on the end of tubing (102). The shuttle sleeve is housed within the body and incorporates a latch device in the form of a collet comprising a plurality of resilient fmgers (14) to releasably connect to the stinger. A ball seat (15) allows hydraulic setting of slips (3). Additional slips (4) can be set by applying tension on the tubing (FIG. 4). Once released, the stinger can open and close the shuttle sleeve by reciprocating in and out of the packer as many times as required during cementing operations.

Abstract: A delivery device for use in administering a dry powder to a biological subject's airway is provided. The device comprises (a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; and (b) one or more cantilever structures located within the housing. Vibration of the one or more cantilever structures facilitates entry of the dry powder into the flow of gas, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway. Also provided is a container for releasably storing a particulate composition, the container comprising a shell sealed by a seal in which the particulate composition is stored, wherein a puncturing device for rupturing the seal to release the particulate composition is housed within the shell. Further provided are associated methods for administering dry powder using the delivery device and/or container.

Abstract: A downhole support device for use in a wellbore is provided, where the device (200) is adapted to be run into the wellbore (202) through or on a workstring (204). The device (200) comprises an inflatable element (206) adapted to be selectively connectable to the workstring (204). The inflatable element (206) selectively applies a biasing force to an external structure such, for example, a wall (214) of the wellbore (202) when in an inflated state. The inflatable element (206) has an inlet (208) for receiving and being inflated by a flowing substance. The device (200) also comprises an inflation mechanism (210) and a disconnect mechanism (222) adapted to be selectively disconnectable from the workstring (204). A method of deploying a barrier in a wellbore which makes use of the support device is also provided.

Abstract: A deformable cleaning element is encased within soluble packaging to maintain deformation. The deformed cleaning element is launched into the bore of a drill pipe/conduit or tubular. Contact with fluids within the bore dissolves the soluble packaging allowing the cleaning element to expand to its original shape.

Abstract: Provided herein are methods and compositions for the treatment of musculoskeletal disorders, including disorders of a joint.

Abstract: A deformable cleaning element is encased within soluble packaging to maintain deformation. The deformed cleaning element is launched into the bore of a drill pipe/conduit or tubular. Contact with fluids within the bore dissolves the soluble packaging allowing the cleaning element to expand to its original shape.

Abstract: A tea bag is configured to be inserted within a water bottle. The tea bag includes a long, thin tea containment bag configured to be inserted within the water bottle and be removed from the water bottle after steeping without compressing with an opening of the water bottle tea leaves within the tea containment bag as the bag is removed from the bottle. The tea bag additionally includes a tea bag line useful to suspend the tea containment bag within the water bottle.