Patents by Inventor John Fraser Keily

John Fraser Keily has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (2-carboxamido)(3-amino)thiophene compounds
    Patent number: 6949563
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3 is C0-4alkyl, are useful in the treatment of cancer.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: September 27, 2005
    Inventors: Graham Michael Wynne, Kevin Doyle, Saleh Ahmed, An-Hu Li, John Fraser Keily, Chrystelle Marie Rasamison, Neil Anthony Pegg, Imaad Saba, Claire Thomas, Don Smyth, Shazia Sadiq, Gary Newton, Graham Dawson, Andrew Phillip Crew, Arlindo Lucas Castelhano
  • Hydroxamic and carboxylic acid derivatives
    Patent number: 6933306
    Abstract: Pharmacologically active compounds are provided as well as pharmaceutical compositions and methods for treating cancer; inflammation; an autoimmune, infectious or ocular disease; or age-related macular degeneration in a mammal.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: August 23, 2005
    Assignee: Darwin Discovery Ltd.
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter
  • (2-carboxamido)(3-amino)thiophene compounds
    Publication number: 20040186124
    Abstract: Compounds represented by Formula (I): 1
    Type: Application
    Filed: January 6, 2004
    Publication date: September 23, 2004
    Inventors: Graham Michael Wynne, Kevin Doyle, Saleh Ahmed, An-Hu Li, John Fraser Keily, Chrystelle Marie Rasamison, Neil Anthony Pegg, Imaad Saba, Claire Thomas, Don Smyth, Shazia Sadiq, Gary Newton, Graham Dawson, Andrew Phillip Crew, Arlindo Lucas Castelhano
  • Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
    Publication number: 20030207889
    Abstract: Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.
    Type: Application
    Filed: April 29, 2003
    Publication date: November 6, 2003
    Inventors: David Alan Owen, John Gary Montana, John Fraser Keily, Robert John Watson, Andrew Douglas Baxter
  • Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
    Patent number: 6566384
    Abstract: Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: May 20, 2003
    Assignee: Darwin Discovery Ltd.
    Inventors: David Alan Owen, John Gary Montana, John Fraser Keily, Robert John Watson, Andrew Douglas Baxter
  • Hydroxamic and carboxylic acid derivatives
    Publication number: 20030092727
    Abstract: Pharmacologically active compounds are provided as well as pharmaceutical compositions and methods for treating cancer; inflammation; an autoimmune, infectious or ocular disease; or age-related macular degeneration in a mammal.
    Type: Application
    Filed: October 25, 2002
    Publication date: May 15, 2003
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter
  • Hydroxamic and carboxylic acid derivatives
    Patent number: 6506773
    Abstract: Pharmacologically active compounds are provided as well as pharmaceutical compositions and methods for treating cancer; inflammation; an autoimmune, infectious or ocular disease; or age-related macular degeneration in a mammal.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: January 14, 2003
    Assignee: Darwin Discovery Ltd.
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter
  • Hydroxamic and carboxylic acid derivatives
    Publication number: 20020022635
    Abstract: A phacologically actve compound of forula (1) 1
    Type: Application
    Filed: May 15, 2001
    Publication date: February 21, 2002
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter
  • Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
    Patent number: 6118001
    Abstract: Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNF.alpha.-mediated diseases, including degenerative diseases and certain cancers.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: September 12, 2000
    Assignee: Darwin Discovery, Ltd.
    Inventors: David Alan Owen, John Gary Montana, John Fraser Keily, Robert John Watson, Andrew Douglas Baxter
  • Peptidyl compounds having MMP and TNF inhibitory activity
    Patent number: 6114372
    Abstract: Compounds of formula (I) having MMP and TNF inhibitory activity.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: September 5, 2000
    Assignee: Darwin Discovery Limited
    Inventors: Andrew Douglas Baxter, David Alan Owen, John Gary Montana, Robert John Watson, John Fraser Keily
  • Peptidyl compounds having MMP and TNF inhibitory activity
    Patent number: 6090840
    Abstract: The subject invention concerns mercaptoalkylacyl compounds of formula (I): ##STR1## The compounds of the subject invention can be used to inhibit matrix metalloproteinases and/or TNF.alpha.- and L-selectin sheddase-mediated diseases including degenerative diseases and cancers. The subject invention also concerns methods of using the compounds of the invention to treat or prevent conditions associated with matrix metalloproteinases or that are mediated by TNF.alpha. or L-selectin sheddase.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: July 18, 2000
    Assignee: Darwin Discovery Limited
    Inventors: Andrew Douglas Baxter, David Alan Owen, John Gary Montana, Robert John Watson, John Fraser Keily