Patents by Inventor John Frederick Currie
John Frederick Currie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11633129Abstract: Systems and methods are provided for determining levels of an analyte in a biological fluid sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological fluid sample; a sensing element comprising at least two sensing electrodes, and at least one layer of a cofactor covering the sensing element in which the cofactor catalyzes a reaction to determine levels of an analyte in the biological fluid sample. The at least one disruptor of the transdermal sampling and analysis device may generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism. The surface of at least one of the sensing electrodes of the transdermal sampling and analysis device may be coated with a sensing layer in which an enzyme immobilized within a hydrogel.Type: GrantFiled: April 2, 2020Date of Patent: April 25, 2023Assignee: Cambridge Medical Technologies LLCInventors: Helena Woodvine Snyder, Vikas Bhatia, John Frederick Currie, Emil F. Jachmann
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Patent number: 11607156Abstract: Systems and methods are provided for determining levels of an analyte in a biological fluid sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological fluid sample; a sensing element comprising at least two sensing electrodes, and at least one layer of a cofactor covering the sensing element in which the cofactor catalyzes a reaction to determine levels of an analyte in the biological fluid sample. The at least one disruptor of the transdermal sampling and analysis device may generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism. The surface of at least one of the sensing electrodes of the transdermal sampling and analysis device may be coated with a sensing layer in which an enzyme immobilized within a hydrogel.Type: GrantFiled: April 2, 2020Date of Patent: March 21, 2023Assignee: Cambridge Medical Technologies LLCInventors: Helena Woodvine Snyder, Vikas Bhatia, John Frederick Currie, Emil F. Jachmann
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Patent number: 11375931Abstract: Systems and methods are provided for determining levels of a target analyte in a biological sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological sample, at least two electrodes, and an electrochemical bioassay configured to determine levels of a target analyte in the biological sample. The at least one disruptor of the transdermal sampling and analysis device may be configured to generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism.Type: GrantFiled: June 13, 2020Date of Patent: July 5, 2022Assignee: Cambridge Medical Technologies LLCInventors: Helena Woodvine Snyder, Vikas Bhatia, John Frederick Currie, Emil F. Jachmann
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Publication number: 20210267501Abstract: Transdermal sampling and analysis devices, methods, and systems are provided. The transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, at least a first sensing electrode and a second sensing electrode, a counter/reference electrode, and a plurality of well areas between a base structure and a lid structure. The at least one disruptor may be configured to generate a localized heat capable of altering permeability characteristics of a subject's skin. The plurality of well areas may be configured to receive a biological fluid sample. Within each well area, the first sensing electrode may be coated with a first analyte sensing layer, the second sensing electrode may be coated with a second analyte sensing layer different from the first analyte sensing layer, and the counter/reference electrode may be configured to be electrically connected to each of the first and second sensing electrodes.Type: ApplicationFiled: February 27, 2020Publication date: September 2, 2021Inventors: Emil F. JACHMANN, John Frederick CURRIE, Vikas BHATIA, John WENSMAN, Georgia CURRIE
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Publication number: 20210128036Abstract: Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.Type: ApplicationFiled: December 21, 2020Publication date: May 6, 2021Inventors: Joseph J. VIDALIS, Joseph A. MARCANIO, John Frederick CURRIE, Helena Woodvine SNYDER, Vikas BHATIA
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Publication number: 20210038127Abstract: Systems and methods are provided for determining levels of a target analyte in a biological sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological sample, at least two electrodes, and an electrochemical bioassay configured to determine levels of a target analyte in the biological sample. The at least one disruptor of the transdermal sampling and analysis device may be configured to generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism.Type: ApplicationFiled: June 13, 2020Publication date: February 11, 2021Inventors: Helena Woodvine SNYDER, Vikas BHATIA, John Frederick CURRIE, Emil F. JACHMANN
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Patent number: 10898116Abstract: Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.Type: GrantFiled: March 13, 2014Date of Patent: January 26, 2021Assignee: Cambridge Medical Technologies LLCInventors: Joseph J Vidalis, Joseph A Marcanio, John Frederick Currie, Helena Woodvine Snyder, Vikas Bhatia
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Publication number: 20200375510Abstract: Systems and methods are provided for determining levels of an analyte in a biological fluid sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological fluid sample; a sensing element comprising at least two sensing electrodes, and at least one layer of a cofactor covering the sensing element in which the cofactor catalyzes a reaction to determine levels of an analyte in the biological fluid sample. The at least one disruptor of the transdermal sampling and analysis device may generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism. The surface of at least one of the sensing electrodes of the transdermal sampling and analysis device may be coated with a sensing layer in which an enzyme immobilized within a hydrogel.Type: ApplicationFiled: April 2, 2020Publication date: December 3, 2020Inventors: Helena Woodvine SNYDER, Vikas BHATIA, John Frederick CURRIE, Emil F. JACHMANN
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Patent number: 9968284Abstract: A system and methods are provided for reducing electrochemical interference in a transdermal sampling and analysis device. A one-step transdermal glucose biosensor may calculate glucose concentrations that are artificially high compared to traditional home blood glucose sensors due to interference, which may be mitigated by forming an anti-interferent barrier layer over a sensing element. The anti-interferent barrier layer may be formed over a sensing layer and may possess a charge type which repels interferent molecules having the same charge type from interacting with the sensing layer disposed below the anti-interferent barrier layer.Type: GrantFiled: November 29, 2012Date of Patent: May 15, 2018Assignee: CLINITECH, LLCInventors: Joseph J Vidalis, Joseph A Marcanio, John Frederick Currie, Sundar Nadarajan, Helena Woodvine
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Publication number: 20140275895Abstract: Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: Flexible Medical Systems LLCInventors: Joseph J. Vidalis, Joseph A. Marcanio, John Frederick Currie, Helena Woodvine Snyder, Vikas Bhatia
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Patent number: 8364228Abstract: A system and method for transdermal sampling wherein at least one pair of sample electrodes is adapted to provide voltage pulses capable of creating capillary openings in a subject's stratum corneum. Methods for using a transdermal sampling system by creating capillary openings in a subject's stratum corneum via the application of a series of voltage pulses to the stratum corneum and contacting at least a portion of at least one of the sample electrodes with interstitial fluid from the capillary openings are also presented.Type: GrantFiled: December 9, 2005Date of Patent: January 29, 2013Assignee: Flexible Medical Systems, LLCInventors: John Frederick Currie, Makarand Paranjape
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Patent number: 8333874Abstract: The present invention generally relates to a system and method that co-locates in a small flexible, configurable system and multi-level substrate sampling, rapid analysis, bio-sample storage and delivery functions to be performed on living tissues or matter obtained from living organisms. The types of the sampling may include chemical, biochemical, biological, thermal, mechanical, electrical, magnetic and optical sampling. In general, the analysis performed at the point of sampling measures the sample taken and records its value. The bio-sample storage function encapsulates a small sample of analyte and preserves it for subsequent examination or analysis, either on the organism by the system or at a remote location by an independent analysis system. Once stored, the sample can provide a record of a biological state at the precise time of sampling. The delivery at the point of sampling can include chemical, biochemical, biological, thermal, mechanical, electrical, magnetic and optical stimuli.Type: GrantFiled: June 14, 2006Date of Patent: December 18, 2012Assignee: Flexible Medical Systems, LLCInventor: John Frederick Currie
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Publication number: 20090281404Abstract: A system and method for transdermal sampling wherein at least one pair of sample electrodes is adapted to provide voltage pulses capable of creating capillary openings in a subject's stratum corneum. Methods for using a transdermal sampling system by creating capillary openings in a subject's stratum corneum via the application of a series of voltage pulses to the stratum corneum and contacting at least a portion of at least one of the sample electrodes with interstitial fluid from the capillary openings are also presented.Type: ApplicationFiled: December 9, 2005Publication date: November 12, 2009Inventors: John Frederick Currie, Makarand Paranjape