Patents by Inventor John Frederick Graf

John Frederick Graf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-beam neuromodulation techniques
    Patent number: 12551729
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: February 17, 2026
    Assignee: GE Precision Healthcare LLC
    Inventors: John Frederick Graf, Christopher Michael Puleo, Jeffrey Michael Ashe, Victoria Eugenia Cotero, David Andrew Shoudy
  • NEUROMODULATION TO TARGET GLUCOSE TRANSPORTER AND/OR INCRETIN PATHWAYS
    Publication number: 20250352127
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
    Type: Application
    Filed: June 9, 2025
    Publication date: November 20, 2025
    Inventors: Victoria Eugenia Cotero, Christopher Michael Puleo, John Frederick Graf
  • Neuromodulation to target glucose transporter and/or incretin pathways
    Patent number: 12336835
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
    Type: Grant
    Filed: July 8, 2024
    Date of Patent: June 24, 2025
    Assignee: GE Precision Healthcare LLC
    Inventors: Victoria Eugenia Cotero, Christopher Michael Puleo, John Frederick Graf
  • NONINVASIVE TISSUE DISPLACEMENT CONTROL AND MONITORING FOR NEUROMODULATION
    Publication number: 20250152973
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
    Type: Application
    Filed: January 15, 2025
    Publication date: May 15, 2025
    Inventors: Jeffrey Michael Ashe, Christopher Michael Puleo, Victoria Eugenia Cotero, Ying Fan, Kirk Dennis Wallace, John Frederick Graf
  • Neuromodulation techniques
    Patent number: 12296202
    Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
    Type: Grant
    Filed: January 29, 2024
    Date of Patent: May 13, 2025
    Assignee: GE PRECISION HEALTHCARE LLC
    Inventors: Christopher Michael Puleo, Lakshmi Sireesha Kaanumalle, Victoria Eugenia Cotero, John Frederick Graf
  • Neuromodulation techniques for perturbation of physiological systems
    Patent number: 12257457
    Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
    Type: Grant
    Filed: July 13, 2022
    Date of Patent: March 25, 2025
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Christopher Michael Puleo, Victoria Eugenia Cotero, Jeffrey Michael Ashe, John Frederick Graf
  • Noninvasive tissue displacement control and monitoring for neuromodulation
    Patent number: 12214223
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
    Type: Grant
    Filed: March 23, 2023
    Date of Patent: February 4, 2025
    Assignee: GE Precision Healthcare LLC
    Inventors: Jeffrey Michael Ashe, Christopher Michael Puleo, Victoria Eugenia Cotero, Ying Fan, Kirk Dennis Wallace, John Frederick Graf
  • NEUROMODULATION TO TARGET GLUCOSE TRANSPORTER AND/OR INCRETIN PATHWAYS
    Publication number: 20240358315
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
    Type: Application
    Filed: July 8, 2024
    Publication date: October 31, 2024
    Inventors: Victoria Eugenia Cotero, Christopher Michael Puleo, John Frederick Graf
  • Neuromodulation to target glucose transporter and/or incretin pathways
    Patent number: 12029577
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: July 9, 2024
    Assignee: GE Precision Healthcare LLC
    Inventors: Victoria Eugenia Cotero, Christopher Michael Puleo, John Frederick Graf
  • NEUROMODULATION TECHNIQUES
    Publication number: 20240189626
    Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
    Type: Application
    Filed: January 29, 2024
    Publication date: June 13, 2024
    Inventors: Christopher Michael Puleo, Lakshmi Sireesha Kaanumalle, Victoria Eugenia Cotero, John Frederick Graf
  • Neuromodulation techniques
    Patent number: 11883689
    Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
    Type: Grant
    Filed: April 18, 2022
    Date of Patent: January 30, 2024
    Assignee: GE Precision Healthcare LLLC
    Inventors: Christopher Michael Puleo, Lakshmi Sireesha Kaanumalle, Victoria Eugenia Cotero, John Frederick Graf
  • MULTI-BEAM NEUROMODULATION TECHNIQUES
    Publication number: 20240001159
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
    Type: Application
    Filed: September 14, 2023
    Publication date: January 4, 2024
    Inventors: John Frederick Graf, Christopher Michael Puleo, Jeffrey Michael Ashe, Victoria Eugenia Cotero, David Andrew Shoudy
  • Multi-beam neuromodulation techniques
    Patent number: 11786760
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: October 17, 2023
    Assignee: GE Precision Healthcare LLC
    Inventors: John Frederick Graf, Christopher Michael Puleo, Jeffrey Michael Ashe, Victoria Eugenia Cotero, David Andrew Shoudy
  • NONINVASIVE TISSUE DISPLACEMENT CONTROL AND MONITORING FOR NEUROMODULATION
    Publication number: 20230226380
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
    Type: Application
    Filed: March 23, 2023
    Publication date: July 20, 2023
    Inventors: Jeffrey Michael Ashe, Christopher Michael Puleo, Victoria Eugenia Cotero, Ying Fan, Kirk Dennis Wallace, John Frederick Graf
  • Noninvasive tissue displacement control and monitoring for neuromodulation
    Patent number: 11633630
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: April 25, 2023
    Assignee: General Electric Company
    Inventors: Jeffrey Michael Ashe, Christopher Michael Puleo, Victoria Eugenia Cotero, Ying Fan, Kirk Dennis Wallace, John Frederick Graf
  • NEUROMODULATION TECHNIQUES FOR PERTURBATION OF PHYSIOLOGICAL SYSTEMS
    Publication number: 20220362587
    Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
    Type: Application
    Filed: July 13, 2022
    Publication date: November 17, 2022
    Inventors: Christopher Michael Puleo, Victoria Eugenia Cotero, Jeffrey Michael Ashe, John Frederick Graf
  • Neuromodulation techniques for perturbation of physiological systems
    Patent number: 11426610
    Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: August 30, 2022
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Christopher Michael Puleo, Victoria Eugenia Cotero, Jeffrey Michael Ashe, John Frederick Graf
  • NEUROMODULATION TECHNIQUES
    Publication number: 20220233888
    Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
    Type: Application
    Filed: April 18, 2022
    Publication date: July 28, 2022
    Inventors: Christopher Michael Puleo, Lakshmi Sireesha Kaanumalle, Victoria Eugenia Cotero, John Frederick Graf
  • NEUROMODULATION TO TARGET GLUCOSE TRANSPORTER AND/OR INCRETIN PATHWAYS
    Publication number: 20220175306
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into the tissue to cause a change in a glucose transporter pathway molecule and/or an incretin pathway molecule. In one embodiment, the neuromodulation is performed as a treatment of a metabolic disorder.
    Type: Application
    Filed: March 12, 2020
    Publication date: June 9, 2022
    Inventors: Victoria Eugenia Cotero, Christopher Michael Puleo, John Frederick Graf
  • Neuromodulation techniques
    Patent number: 11318330
    Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: May 3, 2022
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Christopher Michael Puleo, Lakshmi Sireesha Kaanumalle, Victoria Eugenia Cotero, John Frederick Graf