Patents by Inventor John Frederick TRANT

John Frederick TRANT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermally sensitive protecting groups for cysteine for peptide cyclization and selective disulfide bond formation
    Patent number: 11746114
    Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
    Type: Grant
    Filed: February 4, 2022
    Date of Patent: September 5, 2023
    Inventors: John Frederick Trant, Sarah Nasri, Maryamalsadat Kosar, Sanaz Nadimi, Mohaddeseh Dashti Nejad Pour, Purshotam Sharma, Seyedeh Maryamdokht Taimoory
  • Thermally sensitive protecting groups for cysteine, and manufacture and use thereof
    Patent number: 11560387
    Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: January 24, 2023
    Inventors: John Frederick Trant, Daniel Meister, Sarah Nasri, Anthony Emanuel Chifor, John James Hayward, Seyedeh Maryamdokht Taimoory, Mohadeseh Dashti-Pour
  • Thermally Sensitive Protecting Groups for Cysteine for Peptide Cyclization and Selective Disulfide Bond Formation
    Publication number: 20220153749
    Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
    Type: Application
    Filed: February 4, 2022
    Publication date: May 19, 2022
    Inventors: John Frederick TRANT, Sarah Nasri, Maryamalsadat Kosar, Sanaz Nadimi, Mohaddeseh Dashti Nejad Pour, Purshotam Sharma, Seyedeh Maryamdokht Taimoory
  • Thermally Sensitive Protecting Groups for Cysteine, and Manufacture and Use Thereof
    Publication number: 20220024942
    Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
    Type: Application
    Filed: September 7, 2021
    Publication date: January 27, 2022
    Inventors: John Frederick TRANT, Daniel MEISTER, Sarah NASR!, Anthony Emanuel CHIFOR, John James HAYWARD, Seyedeh Maryamdokht TAIMOORY, Mohadeseh DASHTI-POUR
  • EFFECTIVE ANTIBACTERIAL HYDROPHILIC PHOSPHONIUM POLYMERS WITH LOW HEMOLYTIC ACTIVITY
    Publication number: 20210120822
    Abstract: This disclosure provides phosphonium polymers with increased hydrophilicity exhibiting increased antibacterial activity and decreased hemolytic activity. These phosphonium polymers include Poly(THPvbPCl) poly(tris(3-hydroxypropyl)(vinylbenzyl)phosphonium chloride) and derivatives thereof, ((2,3,4,6-Tetra-O-acetyl-manno-pyranyl)-1-oxy-allyl and derivatives thereof, and poly(dihexyl(2,3,4,6,-hydroxy-gluco-pyranyl)-1-oxy-propyl)vinylbenzylphosphonium chloride) and derivatives thereof.
    Type: Application
    Filed: May 28, 2018
    Publication date: April 29, 2021
    Inventors: Tyler J. CUTHBERT, John Frederick TRANT, Elizabeth Rachel GILLIES, Paul Joseph RAGOGNA
  • Thermally Sensitive Protecting Groups for Cysteine, and Manufacture and Use Thereof
    Publication number: 20210040105
    Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
    Type: Application
    Filed: August 5, 2020
    Publication date: February 11, 2021
    Inventors: John Frederick TRANT, Daniel MEISTER, Sarah NASRI, Anthony Emanuel CHIFOR, John HAYWARD, Seyedeh Maryamdokht TAIMOORY, Mohadeseh DASHTI-POUR
  • POLYMER-DRUG CONJUGATE BASED ON A POLYISOOLEFIN-BASED COPOLYMER
    Publication number: 20170258970
    Abstract: A polymer-drug conjugate, which can be used in medical applications such as stents, has at least one active agent conjugated through a carboxylic acid moiety to a copolymer derived from at least one isoolefin monomer and at least one copolymerizable monomer, where the copolymerizable monomer is at least one multiolefin monomer, a ?-pinene monomer or a mixture thereof. Such conjugates show improved adhesion to stainless steel and a substantial decrease in burst release of paclitaxel form a drug eluting stent (DES).
    Type: Application
    Filed: December 1, 2015
    Publication date: September 14, 2017
    Applicants: ARLANXEO Singapore Pte. Ltd., THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Elizabeth R. GILLIES, Lorenzo FERRARI, Matthew McEACHRAN, John Frederick TRANT, Inderpreet SRAN