Patents by Inventor John Freskos

John Freskos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8481734
    Abstract: Disclosed herein are pyrazine derivatives of Formula I: Formula I; wherein each of X1 and X2 is independently —CONR7R9; and each of Y1 and Y2 is independently —NR48R49; and methods of using the same. The disclosed pyrazine derivatives include those having urea, amide, sulfonamide, thiourea, and/or carbamate substituents. Among the various aspects of the present invention are pyrazine derivatives that may be detected in vivo and used in a number of medical procedures (e.g., renal function monitoring). Without being bound by a particular theory, the pyrazine derivatives described herein may be designed to be hydrophilic, thus allowing for rapid renal clearance for continuous monitoring of renal function.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: July 9, 2013
    Assignee: Medibeacon Development LLC
    Inventors: Richard B. Dorshow, John Freskos, William L. Neumann, Amruta Reddy Poreddy, Raghavan Rajagopalan
  • Patent number: 7727997
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of disorders such as Alzheimer's Disease.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: June 1, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealey, Ruth Tenbrink, Larry Fang, Roy Hom
  • Publication number: 20100021382
    Abstract: Disclosed herein are pyrazine derivatives and methods of using the same.
    Type: Application
    Filed: January 12, 2009
    Publication date: January 28, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Richard B. Dorshow, John Freskos, William L. Neumann, Amruta Reddy Poreddy, Raghavan Rajagopalan
  • Publication number: 20100010223
    Abstract: The present invention relates to methods for producing N,N?-alkylated diaminopyrazines.
    Type: Application
    Filed: January 7, 2009
    Publication date: January 14, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Richard B. Dorshow, John Freskos, William L. Neumann, Amruta Reddy Poreddy, Raghavan Rajagopalan
  • Publication number: 20080118969
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: January 29, 2008
    Publication date: May 22, 2008
    Applicant: G.D. Searle LLC
    Inventors: Daniel Getman, Gary DeCrescenzo, John Freskos, Michael Vazquez, James Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David Brown, Joseph McDonald
  • Publication number: 20080103311
    Abstract: N-heterocyclic moiety containing hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: December 11, 2007
    Publication date: May 1, 2008
    Applicant: Pharmacia Corporation
    Inventors: John Tally, Daniel Getman, Gary DeCrescenzo, Kathryn Reed, Ko-Chung Lin, John Freskos, Michael Clare, Donald Rogier, Robert Heintz, Michael Vazquez, Richard Mueller
  • Publication number: 20070299263
    Abstract: Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compounds of formula X are also disclosed.
    Type: Application
    Filed: December 6, 2006
    Publication date: December 27, 2007
    Inventors: John Freskos, David Brown, Yvette Fobian, Larry Fang, Arthur Romero, Varghese John
  • Publication number: 20070249615
    Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.
    Type: Application
    Filed: April 20, 2007
    Publication date: October 25, 2007
    Inventors: Robert Hughes, Andrew Bell, David Brown, Dafydd Owen, Michael Palmer, Christopher Phillips, David Brown, Yvette Fobian, John Freskos, Steven Heasley, E. Jacobsen, Todd Maddux, Brent Mischke, John Molyneaux, Joseph Moon, D. Rogier, Michael Tollefson, John Walker
  • Publication number: 20070213316
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
    Type: Application
    Filed: December 11, 2006
    Publication date: September 13, 2007
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom
  • Publication number: 20070213407
    Abstract: The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: September 28, 2006
    Publication date: September 13, 2007
    Inventors: Lawrence Fang, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Michel Maillard, Varghese John, Shon Pulley, James Beck, Ruth TenBrink, John Freskos
  • Publication number: 20070078173
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: September 25, 2006
    Publication date: April 5, 2007
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, John Freskos, Robert Heintz, Deborah Bertenshaw
  • Publication number: 20070037754
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human inmmunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: August 10, 2006
    Publication date: February 15, 2007
    Applicant: G.D. Searle & Co.
    Inventors: Daniel Getman, Gary DeCrescenzo, John Freskos, Michael Vazquez, James Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David Brown, Joseph McDonald
  • Patent number: 7176242
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: February 13, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom
  • Publication number: 20070004646
    Abstract: Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: June 12, 2006
    Publication date: January 4, 2007
    Applicant: G.D. Searle & Co.
    Inventors: Daniel Getman, Gary DeCrescenzo, John Freskos, Michael Vazquez, James Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David Brown, Joseph McDonald
  • Publication number: 20060276493
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as-inhibitors of HIV protease.
    Type: Application
    Filed: May 15, 2006
    Publication date: December 7, 2006
    Applicant: G.D Searle & Co.
    Inventors: Michael Vasquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, John Freskos, Deborah Bertenshaw, Robert Heintz
  • Patent number: 7144897
    Abstract: Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compounds of formula X are also disclosed.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: December 5, 2006
    Assignees: Elan Oharmaceuticals, Inc., Pharmacia & Upjohn, Co.
    Inventors: John Freskos, David L. Brown, Yvette M. Fobian, Larry Fang, Arthur Glenn Romero, Varghese John
  • Publication number: 20060264483
    Abstract: Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: April 4, 2006
    Publication date: November 23, 2006
    Applicant: G.D. Searle & Co.
    Inventors: Daniel Getman, Gary DeCrescenzo, John Freskos, Michael Vazquez, James Sikorski, Balekudru Devadas, Srinivasan Nagarajan, Joseph McDonald
  • Publication number: 20060199822
    Abstract: Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein the variables are as defined herein.
    Type: Application
    Filed: February 8, 2006
    Publication date: September 7, 2006
    Applicant: G.D. Searle & Co.
    Inventors: John Freskos, Daniel Getman, John Talley, James Sikorski
  • Publication number: 20060189611
    Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: January 24, 2006
    Publication date: August 24, 2006
    Applicant: G.D. Searle & Co.
    Inventors: Daniel Getman, Gary DeCrescenzo, John Freskos, Michael Vazquez, James Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David Brown, Joseph McDonald
  • Publication number: 20060166895
    Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: January 13, 2006
    Publication date: July 27, 2006
    Applicant: Monsanto Company (now named Pharmacia Corporation, which is a wholly owned subsidiary of Pfizer, Inc
    Inventors: John Talley, Daniel Getman, Gary DeCrescenzo, Kathryn Reed, Ko-Chung Lin, John Freskos, Michael Clare, Donald Rogier, Robert Heintz, Michael Vazquez, Richard Mueller