Abstract: The present invention relates to dosing regimens and methods of administration that are useful for treating RSV infection in patients, such as pediatric patients. The methods described herein involve administration of compound (A) or a pharmaceutically acceptable salt thereof.

Abstract: A method for the treatment of hepatitis C infection genotype 1, 2, 4, 5, or 6, but not genotype 3 is provided comprising administering an effective amount of a combination of Compound (I), Compound (II), and Compound (III), or independently optionally their pharmaceutically acceptable salt, solvate or hydrate, optionally in a solid fixed dose composition.

Abstract: A method for the treatment of hepatitis C infection genotype 1, 2, 4, 5, or 6 is provided comprising administering an effective amount of a combination of Compound (I), Compound (II), and Compound (III), or independently optionally their pharmaceutically acceptable salt, solvate or hydrate, optionally in a solid fixed dose composition.

Abstract: Methods of making an artificial leather substrate from leather waste (e.g., shavings, such as wet blue, and/or pulverized trim scrap) and products formed using the artificial leather substrate are disclosed. In one example, the artificial leather substrate comprises a composite web comprising leather waste mixed with a lightweight web, a lightweight web atop the composite web, and another lightweight web atop the first lightweight web. A method of making the artificial leather substrate includes the steps of mixing one or more fiber components, leather shavings, and/or pulverized leather trim scrap to form the composite web; needle punching the composite web; and bonding the composite web.

Abstract: A composition, including a fixed dose composition, comprising Compound (I), Compound (II), and Compound (III) for the treatment of hepatitis C, and methods of manufacture thereof.

Abstract: A composition, including a fixed dose composition, comprising Compound (I), Compound (II), and Compound (III) for the treatment of hepatitis C, and methods of manufacture thereof.

Abstract: Described herein is a combination that includes compound (A) of the formula and compound (B) of the formula or a pharmaceutically acceptable salt(s) of the foregoing, for ameliorating and/or treating a hepatitis C viral infection.

Abstract: Described herein are methods for treating and/or ameliorating a paramyxovirus infection that include using compound (A), or a pharmaceutically acceptable salt thereof.

Abstract: Methods of making an artificial leather substrate from leather waste (e.g., shavings, such as wet blue, and/or pulverized trim scrap) and products formed using the artificial leather substrate are disclosed. In one example, the artificial leather substrate comprises a composite web comprising leather waste mixed with a lightweight web, a lightweight web atop the composite web, and another lightweight web atop the first lightweight web. A method of making the artificial leather substrate includes the steps of mixing one or more fiber components, leather shavings, and/or pulverized leather trim scrap to form the composite web; needle punching the composite web; and bonding the composite web.

Abstract: Described herein is a combination that includes compound (A) and compound (B), or a pharmaceutically acceptable salt of the foregoing, for ameliorating and/or treating a hepatitis C viral infection.

Abstract: An apparatus for the biological treatment of saltwater-based domestic wastewater, the apparatus having an inlet for the introduction of the saltwater-based domestic wastewater, an outlet for the removal of treated wastewater, means for monitoring the salinity level of the saltwater-based domestic wastewater entering or within the apparatus and means for controlling the salinity level of the saltwater-based domestic wastewater entering or within the apparatus such that fluctuations in the salinity level of the saltwater-based domestic wastewater are reduced and the biological treatment of the saltwater-based domestic wastewater is thereby maintained.

Abstract: A water craft includes a tow tower including a tower loop raised and lowered by two linear actuators. The tower loop is firmly supported in the raised position by the linear actuators to provide a proper attachment for towing enthusiasts, and is lowered to allow the water craft to be stored in a normal height garage structure. The linear actuators are unique designs with large shaft diameter, short stroke, and high overlap between the shaft and actuator body, and in particular include novel compressible bumpers to create a compressive jam-lock counterforce at full extension to effectively jam-lock the linear actuator and prevent back creep.

Abstract: Hygienic, antibacterial, and anti-allergenic pillows or pillow encasings with a covering are disclosed. The covering comprises a fabric coated with a monolithic coating and a filter. The monolithic coating prevents moisture from entering the pillow and allergens from leaving the pillow or pillow encasing. The filter is operative to allow air to egress and ingress the pillow covering.

Abstract: An apparatus for the biological treatment of saltwater-based domestic wastewater, the apparatus having an inlet for the introduction of the saltwater-based domestic wastewater, an outlet for the removal of treated wastewater, means for monitoring the salinity level of the saltwater-based domestic wastewater entering or within the apparatus and means for controlling the salinity level of the saltwater-based domestic wastewater entering or within the apparatus such that fluctuations in the salinity level of the saltwater-based domestic wastewater are reduced and the biological treatment of the saltwater-based domestic wastewater is thereby maintained.

Abstract: A method is provided for determining the origin of a sample of the artificial sweetener sucralose. Stable chlorine isotope analysis is used in the determination. Sucralose is sold under the trademark Splenda® by authorised manufacturers. The ability to determine the origin of a sample of sucralose is particularly useful to manufacturers authorised to use the Splenda® trademark, since it will enable them to monitor the extent of the unauthorised use of the trademark and allow them to take appropriate action in protecting their trademark rights accordingly.

Abstract: Methods for chlorinating sucrose-6-esters to produce 1?,4,6?-trichlorosucrose-6-esters include providing a reaction mixture in a temperature-controlled vessel at a temperature less than about 65° C., the reaction mixture comprising sucrose-6-ester, a tertiary amide, and a chloroformiminium chloride salt, which forms an O-alkylformiminium chloride adduct with the hydroxyl groups of the sucrose-6-ester. The methods for chlorinating the sucrose-6-ester further include subjecting the chloroformiminium chloride salt, tertiary amide, and sucrose-6-ester reaction mixture to an elevated temperature between about 75° C. and 100° C. for a period of time sufficient to produce a chlorinated product mixture of chlorinated sucrose-6-ester products consisting essentially of 1?,4,6?-trichlorogalacto-sucrose-6-ester.

Abstract: The present disclosure provides a process for producing sucralose from a feed mixture of (a) sucralose-6-ester, such as 6-O-acyl-4,1?,6?-trichloro-4,1?,6?-trideoxygalactosucrose, (b) salt including alkali metal or alkaline earth metal chloride, (c) water, and (d) other chlorinated sucrose by-products, in a reaction medium comprising a tertiary amide, wherein said process comprises deacylating, either before or after removal of the tertiary amide, the sucralose-6-ester under active cooling to produce an aqueous solution comprising sucralose, salt including alkali metal or alkaline earth metal chloride, and other chlorinated sucrose by-products. Additionally, the sucralose may be recovered from the aqueous solution, such as by extraction followed by crystallization or by extractive techniques alone.

Abstract: A loan system program comprises a loan account having a loan principal on a purchased item, and a secondary account used to pay the amortized interest on the loan principal. A user deposits, such as through automatic deposit, user payments directly into the loan account, thus paying down the loan principal. The user then uses the secondary account for personal expenses that would otherwise be met by the deposited user payments. At the end of the month or grace period, the user pays off the monthly interest on the loan account with the secondary account. The lender than raises the loan balance of the loan account to cover the secondary account balance. At least a portion of the next user deposit to the loan account covers the raise loan balance, and another portion is used to pay down the loan principal.

Abstract: A method and apparatus for determining the proper satellite communications service to be provided to a subscriber unit that may be integrated with the geographically defined service areas used in terrestrial cellular communications systems. The pre-existing geographically defined service areas are subdivided into quadrilateral tiles wherein each tile corresponds to a single service area. In addition, the tiles are mapped to a grid having a plurality of regularly spaced grid locations. A lookup table is created that references each grid location to the tiles that overlap the grid locations. The position of the subscriber unit and an approximated region of error within which the subscriber unit is likely to be located are used as input. The approximated region of error is mapped to the grid to identify the grid locations that align with the approximated region of error.

Abstract: The invention relates to dry foodstuffs with <10% by wt moisture, containing dipeptide sweetener and optionally a component that is reactive with it, both in a sugar-free and in a sugar-containing form. The invention relates especially to products which also contain flavourings based on aldehydes. With the invention dry foodstuffs are produced with improved sweetness stability and storage stability and improved flavour when the dipeptide sweetener is a sweetening salt of an aspartic-acid-derived dipeptide sweetener and a derivative of a sweetening acid. The particle size of the sweetening salt is preferably smaller than 200 &mgr;m. The invention also relates to processes for production of such dry foodstuffs using the dipeptide sweetener substantially in solid, dry form.